Effects of Regioisomerism on the Antiproliferative Activity of Hydroxystearic Acids on Human Cancer Cell Lines

A series of regioisomers of the hydroxystearic acid (HSA) was prepared, and the effect of the position of the hydroxyl group along the chain on a panel of human cancer cell lines was investigated. Among the various regioisomers, those carrying the hydroxyl at positions 5, 7, and 9 had growth inhibitor activity against various human tumor cell lines, including CaCo-2, HT29, HeLa, MCF7, PC3, and NLF cells. 10-HSA and 11-HSA showed a very weak effect. 8-HSA did not show inhibitory activity in all cell lines. The biological role of 7-HSA and 9-HSA is widely recognized, while little is known about the effects of 5-HSA. Therefore, the biological effects of 5-HSA in HeLa, HT29, MCF7, and NLF cell lines were investigated using the Livecyte’s ptychography technology, which allows correlating changes in proliferation, motility, and morphology as a function of treatment at the same time. 5-HSA not only reduces cell proliferation but also induces changes in cell displacement, directionality, and speed. It is important to characterize the biological effects of 5-HSA, this molecule being an important component of fatty acyl esters of hydroxy fatty acids (FAHFA), a class of endogenous mammalian lipids with noticeable anti-diabetic and anti-inflammatory effects.     

Middle ear prosthesis: significance in magnetic resonance imaging

The Armstrong model of the Schuknecht gel foam and wire prosthesis was tested in the magnetic field of a 1.5 Tesla magnet. The wire component of the prosthesis was found to be non-magnetic. Patients with this prosthesis can therefore undergo MRI examination safely. Two previous articles from the non radiologic literature concerning the magnetic properties of metallic middle ear prostheses are reviewed.     

Rotational Analysis of the ΔvSiH=3-6 Stretching Vibrational Overtones of HSiD3

The nν₁ SiH stretching overtone transitions of trideuterosilane, HSiD₃, have been recorded by Fourier transform spectroscopy (n=3 and 4) and by intracavity laser absorption spectroscopy (n=5 and 6). The unusually weak 3ν₁ band is affected by considerable intensity and energy perturbations. The 4ν₁ band is also strongly perturbed but the interaction with the dark states is more limited and part of the rotational structure of the v₁=4 upper state could be satisfactorily modeled. Less pronounced perturbations affect the v₁=5 level, newly detected by ICLAS. Its rotational structure is locally perturbed by anharmonic coupling with an unidentified vibrational dark state. The global modeling of the interacting dyad allowed the determination of the perturber parameters and the assignment of extra lines due to an intensity transfer from the v₁=5 bright state to the dark state. In agreement with a previous ICLAS study, the 6ν₁ band near 12 113 cm⁻¹ was found free of perturbation. About six hundred line positions could be reproduced with an rms of 4.6×10⁻³ cm⁻¹, leading to a significantly improved set of rovibrational parameters. The striking evolution of the rotational structure, which exhibits fewer and fewer perturbations when the SiH excitation increases, is discussed.     

Entangling macroscopic oscillators exploiting radiation pressure

It is shown that radiation pressure can be profitably used to entangle macroscopic oscillators like movable mirrors, using present technology. We prove a new sufficient criterion for entanglement and show that the achievable entanglement is robust against thermal noise. Its signature can be revealed using common optomechanical readout apparatus.     

Novel and elegant modes of SbF3 coordination in the complexes with azacrown ethers

Synthesis and single-crystal X-ray structures are recorded for three adducts of SbF₃ with different azacrown ethers. [SbF₃·H₂O·L₁], 1, (L₁ = 12,13-benz-1,10-di(azamethyl)-4,7-dioxacyclotetradecane-1,14-dione), triclinic, , a = 11.234(2), b = 11.691(2), c = 8.869(2) Å, = 94.66(3), = 113.12(3), = 67.82(3)°, Z = 2. [SbF₃Cl·H₂O·(HL₂)], 2, (L₂ = monoaza-18-crown-6), orthorhombic, P2₁2₁2₁, a = 8.763(2), b = 13.003(3), a = 16.836(3) Å, Z = 4. [(SbF₃)₂Cl₂·(H₂L₃)], 3, (L₃ = 1,10-diaza-18-crown-6), triclinic, , a = 8.284(2), b = 9.016(2), c = 9.134(2) Å, = 82.92(3), = 65.24(3), = 63.38(3)°, Z = 1. All three structures include SbF₃ neutral molecules in the pyramidal mode and the antimony second coordination sphere is completed up to six in different fashions. In 1 the dimeric (SbF₃)₂ adducts are made up due to the involvement of the symmetry-related fluorine atom in coordination. The distorted octahedron is then completed by water molecule and carbonyl oxygen of L₁. The neutral molecules are joined by coordination and hydrogen bonds in the infinite ribbons. 2 and 3 are both comprised of neutral and charged species also bounded via coordination and hydrogen bonds. L₂ and L₃ in the complexes adopt the form of single and double-charged cations, respectively. The inorganic backbone unites the neutral SbF₃ molecules and chloride anions in the alternative mode. The sixth coordination site in the antimony polyhedron is completed by the water molecule in 2 and the ethereal oxygen atom in 3. Alignment of the inorganic entities within the structures of 2 and 3 is strikingly similar. Hydrogen bonding patterns are discussed.     

Amination of aryl- and vinylacetylenic compounds catalyzed by rhodium(I) complexes

New rhodium-catalyzed amination reactions of arylacetylenes and cyclohexen-1-ylacetylene in the presence of strong bases with the use of carbon dioxide as an auxiliary are described. Secondary amines attack the terminal carbon atom of the triple bond followed by protonation of the adjacent carbon atom. Alternatively, the reaction can proceed further with the addition of the second alkyne molecule. The conditions for the selective synthesis of enamines (up to 87% yield) or α-substituted propynylamines (up to 86% yield) are reported. Dipartimento di Chimica Organica e Industriale dell'Università, Viale delle Scienze, I-43100 Parma, Italia. Dipartimento di Chimica, Università della Calabria, Arcavacata di Rende, I-80036 Cosenza, Italia. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 966–970, May, 1998.