用离子抑制色谱法分析二(2,2,6,6-四甲基-4-哌啶基)马来酸酯合成反应液

建立了用离子抑制色谱法分析二（２,２,６,６－四甲基－４－哌啶基）马来酸酯合成反应液的方法。平均回收率为９８．８％,相对标准偏差为０．５６％,测量的平均相对偏差不大于５．０％。方法简单、快速,可用于工艺条件的选择和质量检测。     

用离子抑制色谱法分析二（2,2,6,6—四甲基—4—哌啶基）马来酸酯合？…

建立了用离子抑制色谱法分析二（２,２,６,６－四甲基－４－哌啶基）马来酸酯合成反应液的方法。平均回收率为９８．８％,相对标准偏差为０．５６％,测量的平均相对偏差不大于５．０％,方法简单,快速,可用于工艺条件的选择和质量检测。     

含胍基强碱性阴离子交换树脂的合成及应用

以大孔型氯甲基化交联苯乙烯-二乙烯基苯聚合物(D301-Cl)为原料,与1,1,3,3-四甲基-2-正丁基胍(BuTMG)进行季铵化反应,合成了一种强碱交换量为2.65mmol/g含胍基的强碱性阴离子交换树脂(SG).合成的SG树脂经红外光谱表征,并评价了该树脂在水中的热稳定性.结果表明:SG树脂在100℃去离子水中保持100h交换量仅下降9.8％,优于商业通用的D201强碱性阴离子交换树脂.考察了SG树脂对碳酸丙烯酯(PC)与乙醇酯交换合成碳酸二乙酯(DEC)的催化性能,发现PC转化率达21.6％,DEC的选择性达到98.0％.     

邻氯苯乙烯-二乙烯基苯强酸性阳离子交换树脂的合成工艺

以邻氯苯乙烯和二乙烯基苯为原料制备了邻氯苯乙烯-二乙烯基苯强酸性阳离子交换树脂,考察了水油比、分散剂、助分散剂等因素对合成树脂的影响。研究表明,该树脂的合成最佳工艺条件为:水油比3:1~4:1,聚乙烯醇与明胶分别为水相质量的0.1%和1.0%,助分散剂为水相质量的0.5%,电解质为水相质量的10%,在40~80℃的成球关键期控制升温速率为20℃/h,在80~110℃以发烟硫酸辅助磺化,得到交换量大于4mmol/g的树脂,优化了该树脂的合成工艺。     

Separativity of modules with finite exchange property

We introduce the notion of separativity of modules and show that many classes of modules possess the separativity. The present work generalizes many known results.     

具有二维超分子结构的{[Ni(oxbe)]2Mg(H2O)2}·2DMF·DMA的合成及晶体结构

合成了一种中心对称的草酰胺桥联异三核配合物{[Ni(oxbe)]2Mg(H2O)2}·2DMF·DMA[oxbe为N-(2-羧基苯)-N'-(2-氨乙基)不对称草酰胺(H3oxbe)的脱氢阴离子;DMF为N,N-二甲基甲酰胺;DMA为二甲胺].用单晶X射线衍射法测定了它的晶体结构,该晶体属单斜晶系,空间群C2/e,晶胞参数a=22.617(5)A,b=17.173(4)A,c=10.881(4)A,β=115.40(2)°,V=3818(2)A3,Ni2MgC30H44N8O13,Mr=866.46,Z=4,Dc=1.508g/cm3,μ(MoKα)=1.075mm-1,F(000)=1808,R=0.0660,wR=0.1772(I＞2б(I)),3755个可观察衍射点.该三核分子为中心对称结构,镁离子位于6个氧原子所构成的变形八面体的中心,两个镍离子则分别位于两端由N3O构成的近似平面四方场中,中心Mg2+与两端的Ni2+通过草酰胺阴离子桥联在一起.     

A Smart Theranostic Nanocapsule for Spatiotemporally Programmable Photo-Gene Therapy

The therapeutic performance of DNAzyme-involved gene silencing is significantly constrained by inefficient conditional activation and insufficient cofactor supply. Herein, a self-sufficient therapeutic nanosystem was realized through the delicate design of DNAzyme prodrugs and MnO₂ into a biocompatible nanocapsule with tumor-specific recognition/activation features. The indocyanine green (ICG)-modified DNA prodrugs are designed by splitting the DNAzyme and then reconstituted into the exquisite catalyzed hairpin assembly (CHA) amplification circuit. Based on the photothermal activation of ICG, the nanocapsule was disassembled to expose the MnO₂ ingredient which was immediately decomposed into Mn²⁺ ions to supplement an indispensable DNAzyme cofactor on-demand with a concomitant O₂ generation for enhancing the auxiliary phototherapy. The endogenous microRNA catalyzes the amplified assembly of DNA prodrugs via an exquisite CHA principle, leading to the DNAzyme-mediated simultaneous silencing of two key tumor-involved mRNAs. This self-activated theranostic nanocapsule could substantially expand the toolbox for accurate diagnosis and programmable therapeutics.     

THE AUTOMORPHISMS OF NON-DEFECTIVE ORTHOGONAL GROUPS IN CHARACTERISTIC 2

Let V be a non-defective n-dimensional quadratic space over a field F of characteristic2.In this paper we prove that,when n≥6 with n≠8 and F≠F_2,any automorphism ofΩ(V)orO'(V)has the standard type Φ_g,sending σ to gσg~(-1),where g is a semilinearautomorphism of V which preserves the quadratic structure.Therefore the automorphismgroups Aut Ω(V) and Aut O'(V)are isomorphic to PΓO(V).As a corollary,Aut O(V)and Aut O~+(V) are isomorphic to PΓO(V)as well.