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101.
Francine Medjiofack Djeujo Valeria Francesconi Maddalena Gonella Eugenio Ragazzi Michele Tonelli Guglielmina Froldi 《Molecules (Basel, Switzerland)》2022,27(2)
Diabetes mellitus is characterized by chronic hyperglycemia that promotes ROS formation, causing severe oxidative stress. Furthermore, prolonged hyperglycemia leads to glycation reactions with formation of AGEs that contribute to a chronic inflammatory state. This research aims to evaluate the inhibitory activity of α-mangostin and four synthetic xanthenone derivatives against glycation and oxidative processes and on α-glucosidase, an intestinal hydrolase that catalyzes the cleavage of oligosaccharides into glucose molecules, promoting the postprandial glycemic peak. Antiglycation activity was evaluated using the BSA assay, while antioxidant capacity was detected with the ORAC assay. The inhibition of α-glucosidase activity was studied with multispectroscopic methods along with inhibitory kinetic analysis. α-Mangostin and synthetic compounds at 25 µM reduced the production of AGEs, whereas the α-glucosidase activity was inhibited only by the natural compound. α-Mangostin decreased enzymatic activity in a concentration-dependent manner in the micromolar range by a reversible mixed-type antagonism. Circular dichroism revealed a rearrangement of the secondary structure of α-glucosidase with an increase in the contents of α-helix and random coils and a decrease in β-sheet and β-turn components. The data highlighted the anti-α-glucosidase activity of α-mangostin together with its protective effects on protein glycation and oxidation damage. 相似文献
102.
Francine Ziquinatti Roberson G. Hugen César M. Oliveira Luiz A. F. Coelho Sérgio H. Pezzin 《Macromolecular Symposia》2005,229(1):276-280
Summary: Aiming the development of high toughness polymer materials, blends of poly(styrene-co-acrylonitrile) (SAN) and poly(butadiene-co-acrylonitrile) (NBR) rubbers, with contents of acrylonitrile (AN) varying from 21 to 45%, were prepared by casting, coprecipitation and monoscrew extrusion followed by injection molding. SAN/NBR blends, prepared in the compositions (w/w) 90/10, 80/20, 70/30, 60/40, and 50/50, were characterized by differential scanning calorimetry (DSC) and Izod impact tests. DSC analyses showed that blends with 33% AN NBR prepared by casting, and with 39% AN NBR prepared by coprecipitation, are partially miscible at 60/40, 70/30 and 80/20 (SAN/NBR) compositions and immiscible for 50/50 compositions. On the other hand, 90/10 SAN/NBR systems were totally miscible. The blends with 45% AN NBR prepared by coprecipitation showed partial miscibility to 50/50, 60/40, 70/30 and 90/10 compositions and total miscibility to 80/20 composition. The NBR addition results in a significant increase in the impact resistance, strongly dependent on the blend composition and the NBR AN content. The best result of impact resistance — 75.2 ± 8.6 (kJ · m−2) — was obtained for SAN/NBR 50/50, using 45% AN NBR. This value is 15.7 times bigger than that for pure SAN -4.8 ± 0.7 (kJ · m−2). 相似文献
103.
104.
The dispersion relation is derived for the coherent waves in fluid or elastic media supporting viscous and thermal effects and containing randomly distributed spherical scatterers. The formula obtained is the generalization of Lloyd and Berry's [Proc. Phys. Soc. London 91, 678-688 (1967)], the latter being limited to fluid host media, and it is the three-dimensional counterpart of that derived by Conoir and Norris [Wave Motion 47, 183-197 (2010)] for cylindrical scatterers in an elastic host medium. 相似文献
105.
Francieli M. Libero Maurício C.D. Xavier Francine N. Victoria Patrícia S. Nascente Lucielli Savegnago Gelson Perin Diego Alves 《Tetrahedron letters》2012,53(24):3091-3094
We describe herein the synthesis and antifungal activity of new 5-arylchalcogenoalkyl-1H-tetrazoles 4. Arylchalcogenoalkyl-1H-tetrazoles 4 have been synthesized in high yields by reaction of arylchalcogenolate anions with chloronitriles 2, and subsequent [2+3] cycloaddition of resulting arylchalcogenoalkylnitriles 3 with sodium azide by zinc catalysis in aqueous solution. The obtained compound 4a was screened for antifungal activity and presented inhibitory property against seven fungal strains. This protocol is an efficient method to produce new selenium–nitrogen compounds with antifungal activity. 相似文献
106.
Juliana Cordeiro Cardoso Ricardo Luiz C. AlbuquerqueJr. Francine Ferreira Padilha Felipe Oliveira Bittencourt Osvaldo de Freitas Paula Santos Nunes Newton L. Pereira Maria José Vieira Fonseca Adriano Antunes S. Araújo 《Journal of Thermal Analysis and Calorimetry》2011,104(1):249-254
The use of biodegradable natural polymers has increased due to the over-solid packaging waste. In this study, a chemical modification
of the casein molecule was performed by Maillard reaction, and the modified polymer was evaluated by polyacrylamide gel electrophoresis
(PAGE), thermogravimetry/derivative thermogravimetry (TG/DTG), FT-IR, and 1H-NMR spectroscopy. Subsequently, films based on the modified casein were obtained and characterized by mechanical analysis,
water vapor transmission, and erosion behavior. The PAGE results suggested an increase of molecular mass of the modified polymer,
and FT-IR spectroscopy data indicated inclusion of C–OH groups into this molecule. The TG/DTG curves of modified casein presented
a different thermal decomposition profile compared to the individual compounds. Mechanical tests showed that the chemical
modification of the casein molecules provided higher elongation rates (45.5%) to the films, suggesting higher plasticity,
than the original molecules (13.4%). The modified casein films presented higher permeability (0.505 ± 0.006 μg/h mm3) than the original polymer (0.387 ± 0.006 μg/h mm3) films at 90% relative humidity (RH). In pH 1.2, modified casein films presented higher erosion rates (32.690 ± 0.692%) than
casein films (19.910 ± 2.083%) after 8 h, suggesting an increased sensibility for erosion of the modified casein films in
acid environment. In water (pH 7.0), the films erosion profiles were similar. Those findings indicate that the modification
of molecule by Maillard reaction provided films more plastic, hydrophilic, and sensitive to erosion in acid environment, suggesting
that a new polymer with changed properties was founded. 相似文献
107.
Mouhamad Jida Mohamad Soueidan Nicolas Willand Francine Agbossou-Niedercorn Lydie Pelinski Guillaume Laconde Rebecca Deprez-Poulain Benoit Deprez 《Tetrahedron letters》2011,52(14):1705-1708
A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry. 相似文献
108.
Mills NS Cheng FE Baylan JM Tirla C Hartmann JL Patel KC Dahl BJ McClintock SP 《The Journal of organic chemistry》2011,76(2):645-653
Dications of 9-(3-phenyl-1H-inden-1-ylidene)-5H-dibenzo[a,d]cycloheptene, 5(2+), were prepared by oxidation with SbF(5) in SO(2)ClF, and their magnetic behavior was compared to dications of 9-(3-phenyl-1H-inden-1-ylidene)-9H-fluorene, 2(2+). The good correlation between the experimental (1)H NMR shifts for the dications that were oxidized cleanly and the chemical shifts calculated by the GAIO method supported the use of the nucleus independent chemical shifts, NICS, to evaluate the antiaromaticity of the indenyl systems of 2(2+)/5(2+) and their unsubstituted parent compounds, 6(2+) and 7(2+), as well as the antiaromaticity of the fluorenyl system of 2(2+)/7(2+) and the aromaticity of the dibenzotropylium system of 5(2+)/6(2+). Antiaromaticity was shown to be directly related to the amount of charge in the antiaromatic systems, with the antiaromatic systems more responsive to changes in the calculated NBO charge than the aromatic systems. The antiaromaticity was also shown to be directly related to the amount of delocalization in the ring system. The aromaticity of the dibenzotropylium system was much less responsive to changes in the amount of charge in the tropylium system, because the aromatic system was much more completely delocalized. Thus, antiaromatic species are more sensitive probes of delocalization than aromatic ones. 相似文献
109.
2,6-Diisopropylphenol (propofol) is a potent anesthetic drug with fast onset of the anesthetic effect and short recovery time for the patients. Outside of the United States, propofol is widely used in performing target controlled infusion anesthesia. With the long term vision of an electrochemical sensor for in vivo monitoring and feedback controlled dosing of propofol in blood, different alternatives for the electrochemical quantification of propofol using diverse working electrodes and experimental conditions are presented in this contribution. When the electrochemical oxidation of propofol takes place on a glassy carbon working electrode, an electrochemically active film grows on the electrode surface. The reduction current of the film is proportional to the propofol concentration and the accumulation time. Based on these findings a stripping analytical method was developed for the detection of propofol in acidic solutions between 0 and 30 μM, with a detection limit of 5.5±0.4 μM. By restricting the scanned potential window between 0.5 V and 1.0 V in cyclic voltammetric experiments, the formation of the electrochemically active polymer can be prevented. This allowed the development of a direct voltammetric method for assessing propofol in acidic solutions between 0 and 30 μM, with a 3.2±0.1 μM (n=3) detection limit. The stripping method has a better sensitivity but somewhat worse reproducibility because the electrode surface has to be renewed between each experiment. The direct method does not require the renewal of the electrode surface between measurements but has no adequate selectivity towards the common interfering compounds. 相似文献
110.
Florian Medina Nathalie Duhal Christophe Michon Francine Agbossou-Niedercorn 《Comptes Rendus Chimie》2013,16(4):311-317
The catalyst-free reactions of activated alkenes with primary and secondary amines were investigated leading to various mono- and di-hydroamination products, the latter being rare and original. These reactions were shown to depend first on the strength of the nucleophile. Temperature and steric hindrance of the reagents were the other key factors controlling the selectivity of these aza-Michael reactions. In spite of their poor nucleophilicities, some N-heterocyclic amines could react with different activated alkenes affording valuable intermediates. Such results tended to demonstrate the hydrogen-bonding interactions between activated alkenes and poly-nitrogen aromatic cycles may control these concerted or fully conjugate aza-Michael additions. 相似文献