Understanding the Stability and Lifetime of Emulsions

This paper aims to review the various degradation pathays of emulsions. Aging of emulsions may proceed through three distinct microscopic mechanisms: diffusion or permeation, dewetting, and coalescence, each one being associated with a very characteristic growth scenario. We show within this context how double emulsions are a unique tool to complete the basic understanding of emulsion metastability.     

Directed ortho-lithiation of unprotected diphenylphosphinic acids

Directed ortho lithiation of diphenylphosphinic acid and subsequent electrophilic trapping provides mono ortho-functionalized derivatives including enantiopure γ-aminophosphinic acids in moderate yields. Copper catalyzed coupling of the ortho anion leads to biphenyl-2,2′-diylbis(phenylphosphinic acid), a phosphorus analogue of biphenyl-2,2′-dicarboxylic acid. Preliminary studies of the metal-binding abilities of this O,O-chelating ligand towards a series of metal cations are included.     

Multiple Keys for a Single Lock: The Unusual Structural Plasticity of the Nucleotidyltransferase (4′)/Kanamycin Complex

The most common mode of bacterial resistance to aminoglycoside antibiotics is the enzyme‐catalysed chemical modification of the drug. Over the last two decades, significant efforts in medicinal chemistry have been focused on the design of non‐ inactivable antibiotics. Unfortunately, this strategy has met with limited success on account of the remarkably wide substrate specificity of aminoglycoside‐modifying enzymes. To understand the mechanisms behind substrate promiscuity, we have performed a comprehensive experimental and theoretical analysis of the molecular‐recognition processes that lead to antibiotic inactivation by Staphylococcus aureus nucleotidyltransferase 4′(ANT(4′)), a clinically relevant protein. According to our results, the ability of this enzyme to inactivate structurally diverse polycationic molecules relies on three specific features of the catalytic region. First, the dominant role of electrostatics in aminoglycoside recognition, in combination with the significant extension of the enzyme anionic regions, confers to the protein/antibiotic complex a highly dynamic character. The motion deduced for the bound antibiotic seem to be essential for the enzyme action and probably provide a mechanism to explore alternative drug inactivation modes. Second, the nucleotide recognition is exclusively mediated by the inorganic fragment. In fact, even inorganic triphosphate can be employed as a substrate. Third, ANT(4′) seems to be equipped with a duplicated basic catalyst that is able to promote drug inactivation through different reactive geometries. This particular combination of features explains the enzyme versatility and renders the design of non‐inactivable derivatives a challenging task.     

Effect of acetate on ferrihydrite crystallization

Mössbauer spectroscopy was used to follow the aging of ferrihydrite with different amounts of acetate, to achieve more crystalline products. Mössbauer spectra of fresh samples did not show any magnetic components. After two years aging, the solids presented crystalline fractions. Hematite formation was inhibited as acetate content increased in solids. For an acetate/iron molar ratio equal to 0.63 goethite was formed instead of hematite. X-ray diffraction confirmed these results. This work shows that synthetic samples can be used for elucidating the anti-hematitic effect of organic matter already detected in soils.     

Comparison theorems for the volume of a complex submanifold of a Kaehler manifold

LetM be a Kaehler manifold of real dimension 2n with holomorphic sectional curvatureK _H≥4λ and antiholomorphic Ricci curvatureρ _A≥(2n−2)λ, andP is a complex hypersurface. We give a bound for the quotient (volume ofP)/(volume ofM) and prove that this bound is attained if and only ifP=C P ⁿ⁻¹(λ) andM=C P ⁿ(λ). Moreover, we give some results on the volume of of tubes aboutP inM. Work partially supported by a DGICYT Grant No. PS87-0115-CO3-01.     

Vector Equilibrium Problems Under Asymptotic Analysis

Given a closed convex set K in Rⁿ; a vector function F:K×K R^m; a closed convex (not necessarily pointed) cone P(x) in ^m with non-empty interior, PP(x) Ø, various existence results to the problemfind xK such that F(x,y)- int P(x) y K under P(x)-convexity/lower semicontinuity of F(x,) and pseudomonotonicity on F, are established. Moreover, under a stronger pseudomonotonicity assumption on F (which reduces to the previous one in case m=1), some characterizations of the non-emptiness of the solution set are given. Also, several alternative necessary and/or sufficient conditions for the solution set to be non-empty and compact are presented. However, the solution set fails to be convex in general. A sufficient condition to the solution set to be a singleton is also stated. The classical case P(x)=^m ₊ is specially discussed by assuming semi-strict quasiconvexity. The results are then applied to vector variational inequalities and minimization problems. Our approach is based upon the computing of certain cones containing particular recession directions of K and F.     

Evaluating Individual Market Power in Electricity Markets via Agent-Based Simulation

We use agent-based simulation in a coordination game to analyse the possibility of market power abuse in a competitive electricity market. The context of this was a real application to the England and Wales electricity market as part of a Competition Commission Inquiry into whether two particular generators could profitably influence wholesale prices. The research contributions of this paper are both in the areas of market power and market design policy issues for electricity markets, and in the methodological use of large industry-wide evolutionary simulation models.     

Separation in distributive congruence lattices

We define separable sets in algebraic lattices. For a finitely generated congruence distributive variety V \mathcal{V} , we show a close connection between non-separable sets in congruence lattices of algebras in V \mathcal{V} and the structure of subdirectly irreducible algebras in V \mathcal{V} . We apply the general results to some lattice varieties.