Design,Synthesis, and Characterization of Photolabeling Probes for the Study of the Mechanisms of the Antiviral Effects of Ribavirin

Ribavirin, the only small molecule available so far for treating hepatitis‐C‐virus infection, was recently used in an emergency context to treat patients with severe acute respiratory syndrome (SARS) in the early stages of the disease. To study the mechanisms responsible for the antiviral effects of ribavirin by using a photolabeling approach, we designed, synthesized, and characterized the azidotriazole nucleosides 1 and 2 as photolabeling probes of ribavirin. These probes were synthesized either by performing nucleophilic substitution of the corresponding bromotriazole nucleoside with NaN₃ (Scheme 2) or by directly coupling the azidotriazole with the protected ribose sugar (Scheme 4). The azidotriazole nucleosides 1 and 2 showed a fast, clear‐cut photochemical reaction, which suggests that they are promising candidates for use in photolabeling studies.     

Studies on Interactions of Antibiotics with Serum Albumin by Surface Plasmon Resonance Biosensor

Introduction Humanserumalbumin(HSA)isawell known transportproteinforavarietyofmoleculesandions[1].Thebindingofadrugtoserumalbuminhasimportant pharmacokineticconsequencesbecauseitinfluences distribution,excretionandpharmacologicaleffectsof thedruginthebody…     

咪喹莫特的波谱学数据与结构表征

对咪喹莫特的红外(IR)、紫外(UV)、质谱(MS)、氢-氢相关谱(^1H--^1H COSY)、碳氢相关谱(HMQC)、碳氢远程相关谱(HMBC)予以解析并进行了报道。对所有的^1H NMR、^13C NMR谱的信号进行了归属；讨论了质谱的主要碎片离子的可能的裂解方式和红外特征吸收峰所对应的官能团的振动形式。     

用共振光散射技术研究蛋白质与丽春红2R的相互作用

在pH3．50的Britton-Robinson缓冲溶液中，丽春红2R与蛋白质发生结合反应，使最大波长为352．5nm的共振散射光谱得到加强。据此建立了利用丽春红2R作探针，用共振散射光谱技术测定蛋白质的新方法。散射光强度与牛血清白蛋白(BSA)、人血清白蛋白(HAS)和免疫球蛋白(IgG)的浓度在0．25～17．5μg／mL范围内成正比。方法的稳定性好，快速、简便，绝大多数氨基酸、金属离子均不产生干扰，用于人血清样品中蛋白质的测定，获得了满意的结果，加标回收率为93．4％～100．1％。     

合成气在Rh（111）上转化为乙醇的机理的键级守恒研究

Rh上乙醇的生成机理,目前主要有两类.一是Ichikawa等为代表提出的“CO解离—CH_x(x=2或3)—乙酰基—乙醇”机理;另一是蔡启瑞等的“CO缔合—甲酰基(金属氧卡宾)—卡宾—乙烯酮—乙酰基—乙醇”机理.本文用Shustorovich的键级守恒—Morse势(BOC-MP)法对其进行了研究     

TONO萃取金(Ⅳ)及其机理的研究

本文研究在盐酸介质中以三辛胺氮氧化物(分子式为(C_8H)O,简称TOO),萃取金(Ⅲ)的行为及其机理。用等温曲线、斜率、Job法、紫外光谱、摩尔电导、红外和核磁共振等方法确定了萃合物的组成,表明系由两个TOO分子和H~+发生氢键作用,并与AuCl形成离子缔合物,其组成可表述为[TON0…H~+…0NOT]AuCl_4-。     

利用DPN技术直接构建磁性纳米图形

在纳米尺度下构建有序的磁性模板和图形是当前的研究热点之一 [1,2 ] .这种模板在生物样品的分离[1] 、磁电子学研究和信息存储 [2 ] 等领域具有重要意义 .目前 ,光刻 [3] 、微触点印刷 [4 ] 和自组装 [5] 等多项技术已被用来构建各种纳米模板 .1 999年 ,美国西北大学 Mirkin小组 [6 ]发明的 Dip- pen纳米刻蚀技术 (简称 DPN技术 )更在可控组装方面显示出巨大优越性 .这项技术是在一定驱动力作用下 ,使吸附在原子力显微镜 ( AFM)针尖上的分子“墨水”逐渐转移到基底表面上 ,实现纳米模板的可控构建 .与传统技术相比 ,DPN技术可在纳米尺…     

1，4-双(1′-苯基-3′-甲基-5′-氧代吡唑-4′-基)丁二酮-(1，4)合双铜(Ⅱ)配合物的合成、表征、非等温热分解反应动力学及电化学性质

The paper reported the synthetic procedure and character of Copper(Ⅱ) binuclear coordination compound of 1,4-bis-(1′-phenyl-3′-methyl-5′-pyrazolone-4′)-1,4-butanedione. The non-isothermal kinetic of the thermal decomposition of the complex has been studied from the TG-DTG curves by means of the Achar et al and Coats-Redfern methods. The electrochemical characterization of the complex were studied by means of powder microelectrodes technique.     

Synthesis of aziridines from imines and ethyl diazoacetate in room temperature ionic liquids

The synthesis of aziridines from imines and ethyl diazoacetate in room temperature ionic liquids is reported. The reactions proceed readily under mild conditions with high cis selectivities and high yields.     

Coating Carbon Nanotubes with Europium Oxide

Carbon nanotubes (CNTS) coating with europium oxide by a simple method is reported in this letter for the first time. The CNTS were refluxed in a solution of nitric acid containing europium nitrate, and the pH value was subsequently ajusted with ammonia solution. At last, the mixture was filtered and annealed. The TEM micrograph showed that the CNTS were covered with a uniform thin layer with thickness of about 15 nm. The XRD results revealed that the CNTS were coated with europium oxide.