Synthesis,characterization and molecular docking studies of thiouracil derivatives as potent thymidylate synthase inhibitors and potential anticancer agents

Thymidylate synthase (TS), one of folate-dependent enzymes, is a key and well-recognized target for anticancer agents. In this study, a series of 6-aryl-5-cyano thiouracil derivatives were designed and synthesized in accordance with essential pharmacophoric features of known TS inhibitors. Nineteen compounds were screened in vitro for their anti-proliferative activities toward HePG-2, MCF-7, HCT-116, and PC-3 cell lines. Compounds \(\mathbf{21}_{\mathbf{c}}\), \(\mathbf{21}_{\mathbf{d}}\), and 24 exhibited high anti-proliferative activity, comparable to that of 5-fluorouracil. Additionally, ten compounds with potent anti-proliferative activities were further evaluated for their ability to inhibit TS enzyme. Six compounds (\(\mathbf{21}_{\mathbf{b}}\), \(\mathbf{21}_{\mathbf{c}}\), \(\mathbf{21}_{\mathbf{d}}\), 22, 23 and 24) demonstrated potent dose-related TS inhibition with \(\hbox {IC}_{50}\) values ranging from 1.57 to \(3.89\,\upmu \hbox {M}\). The in vitro TS activity results were consistent with those of the cytotoxicity assay where the most potent anti-proliferative compounds of the series showed good TS inhibitory activity comparable to that of 5-fluorouracil. Furthermore, molecular docking studies were carried out to investigate the binding pattern of the designed compounds with the prospective target, TS (PDB-code: 1JU6).     

Generation of an arbitrary chirped microwave waveform with high time-bandwidth product for increasing range resolution of RADAR by using photonic technique

An approach for photonic generation of an arbitrary chirped microwave waveform with an increased time-bandwidth product (TBWP) is proposed and experimentally demonstrated. In the proposed model, light from the mode locked laser is splitted into two parts by using 1 × 2 power splitter: one is sent to linearly chirped fiber Bragg grating (LCFBG) through circulator and the other is time delayed by fiber delay line. The optical pulse in upper arm is time stretched by the LCFBG. Meanwhile, the optical pulse in lower arm experiences a time delay and then stretched by the dispersive single mode fiber. Temporal interference pattern is generated with an increasing or decreasing free spectral range by combination of two time-stretched optical pulses. Finally, the temporal interference pattern which is obtained at the output of optical coupler is transformed into an arbitrary chirped microwave waveform by using a photo-detector. The main advantage of this proposed model is high TBWP in the range of 750–1000 which ultimately results in an increased range resolution of radio detection and ranging.     

High-lying excited states in <Superscript>10</Superscript>Be from the <Superscript>9</Superscript>Be(<Superscript>9</Superscript>Be,<Superscript>10</Superscript>Be)<Superscript>8</Superscript>Be reaction

A transfer-reaction experiment of ⁹Be(⁹Be, ¹⁰Be)⁸Be was performed at a beam energy of 45 MeV. Excited states in ¹⁰Be up to 18.80 MeV are produced using missing mass and invariant mass methods. Most of the observed high-lying resonant states, reconstructed from the α + ⁶He and t + ⁷Li decay channels, agree with the previously reported results. In addition, two new resonances at 15.6 and 18.8 MeV are identified from the present measurement. The 18.55 MeV state is found to decay into both the t + ⁷Li_g.s. and t + ⁷Li* (0.478 MeV) channels, with a relative branching ratio of 0.93 ± 0.33. Further theoretical investigations are encouraged to interpret this new information on cluster structure in neutron-rich light nuclei.     

Enhancement of electrochemical properties of Ca<Subscript>3</Subscript>Co<Subscript>4</Subscript>O<Subscript>9</Subscript> as anode materials for lithium-ion batteries by transition metal doping

Misfit-layered calcium cobaltites (Ca₃Co₄O₉, Ca₃Co_3.9Fe_0.1O₉, and Ca₃Co_3.9Mn_0.1O₉), as anode materials for lithium-ion batteries, were synthesized by a simple hydro-decomposition method. All synthesized samples do not show any impurity phase. They exhibited plate-like particle with the particle size of 1–2 μm. The specific capacities of doped samples showed higher electrochemical performance compared to the undoped sample. After charge/discharge of 50 cycles, the specific capacities of Ca₃Co₄O₉, Ca₃Co_3.9Fe_0.1O₉, and Ca₃Co_3.9Mn_0.1O₉ were 343, 562, and 581 mAh g^?1, respectively. The doped samples showed an increase of over 60% compared to the undoped sample. The cyclic voltammetry profile of the doped samples showed the enhanced reactivity corresponding to their improved electrochemical performance. The capacity improvement of doped samples resulted from the metal oxide/Li conversion reactions, volume change, and high reactivity.     

On adaptive modified projective synchronization of a supply chain management system

In this paper, the synchronization problem of a chaotic supply chain management system is studied. A novel adaptive modified projective synchronization method is introduced to control the behaviour of the leader supply chain system by a follower chaotic system and to adjust the leader system parameters until the measurable errors of the system parameters converge to zero. The stability evaluation and convergence analysis are carried out by the Lyapanov stability theorem. The proposed synchronization and antisynchronization techniques are studied for identical supply chain chaotic systems. Finally, some numerical simulations are presented to verify the effectiveness of the theoretical discussions.     

Drop deposition of thin nanostructured coatings of lead telluride

The current-voltage relationships of deposited structures are measured for cluster structures consisting of nanoparticles of lead telluride. Variation in the value of the tunnel current is shown. Optimum conditions for the possible emergence of quantum-hopping conductivity due to carrier tunneling (the characteristic sizes of the nanoclusters and the distances between them) are determined.     

A Total Measure of Multi-Particle Quantum Correlations in Atomic Schrödinger Cat States

We propose a total measure of multi-particle quantum correlation in a system of N two-level atoms (N qubits). We construct a parameter that encompasses all possible quantum correlations among N two-level atoms in arbitrary symmetric pure states and define its numerical value to be the total measure of the net atom-atom correlations. We use that parameter to quantify the total quantum correlations in atomic Schrödinger cat states, which are generated by the dispersive interaction in a cavity. We study the variation of the net amount of quantum correlation as we vary the number of atoms from N=2 to N=100 and obtain some interesting results. We also study the variation of the net correlation, for fixed interaction time, as we increase the number of atoms in the excited state of the initial system, and notice some interesting features. We also observe the behaviour of the net quantum correlation as we continuously increase the interaction time, for the general state of N two-level atoms in a dispersive cavity.