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81.
82.
New pyrazolino and pyrrolidino[60]fullerenes: the introduction of the hydrazone moiety for the formation of metal complexes
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Elkin L. Romero Andrea Cabrera‐Espinoza Nathaly Ortiz‐Peña Mónica Soto‐Monsalve Fabio Zuluaga Richard F. D'Vries Manuel N. Chaur 《Journal of Physical Organic Chemistry》2017,30(2)
The [3 + 2] cycloaddition reaction of C60 with pyridine‐derived hydrazones (acting as dipolar reagents) was successfully conducted resulting in fullerene derivatives 5a , 5b . The compounds were characterized by means of NMR, UV–Vis spectroscopy, and X‐ray crystallography. The electrochemical behavior was also investigated. The fulleropyrazoline 5a exhibits anodically shifted reduction potentials of about 100 mV when compared with those for C60, whereas 5b exhibits cathodic shifts relative to pristine C60. The complexation reaction of 5b with metallic ions (Zn2+, Cd2+, and Fe2+) was achieved. Job and Benesi–Hildebrand analysis confirmed the formation of complexes with a molar ratio of 1:1 and binding constants between 2.26 × 105 and 1.59 × 105 M?1. Electrochemistry of these complexes showed a marked influence of the metal ion on the reduction potentials. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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Summary Lignin was isolated from the wood ofLarix sibirica by the mechanical grinding method. The functional composition of the lignin was determined and a semiempirical formula was calculated for the C6C3 structural unit.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimisheskaya, No. 7, pp. 1279–1280, July, 1965 相似文献
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Vanessa Loaiza-Cano Laura Milena Monsalve-Escudero Manuel Pastrana Restrepo Diana Carolina Quintero-Gil Sergio Andres Pulido Muoz Elkin Galeano Wildeman Zapata Marlen Martinez-Gutierrez 《Molecules (Basel, Switzerland)》2021,26(11)
Despite the serious public health problem represented by the diseases caused by dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses, there are still no specific licensed antivirals available for their treatment. Here, we examined the potential anti-arbovirus activity of ten di-halogenated compounds derived from L-tyrosine with modifications in amine and carboxyl groups. The activity of compounds on VERO cell line infection and the possible mechanism of action of the most promising compounds were evaluated. Finally, molecular docking between the compounds and viral and cellular proteins was evaluated in silico with Autodock Vina®, and the molecular dynamic with Gromacs®. Only two compounds (TDC-2M-ME and TDB-2M-ME) inhibited both ZIKV and CHIKV. Within the possible mechanism, in CHIKV, the two compounds decreased the number of genome copies and in the pre-treatment strategy the infectious viral particles. In the ZIKV model, only TDB-2M-ME inhibited the viral protein and demonstrate a virucidal effect. Moreover, in the U937 cell line infected with CHIKV, both compounds inhibited the viral protein and TDB-2M-ME inhibited the viral genome too. Finally, the in silico results showed a favorable binding energy between the compounds and the helicases of both viral models, the NSP3 of CHIKV and cellular proteins DDC and β2 adrenoreceptor. 相似文献
87.
Sedykh G. S. Gorbachev E. V. Elkin V. G. 《Physics of Particles and Nuclei Letters》2020,17(4):604-606
Physics of Particles and Nuclei Letters - RestDS2 is a Tango class which implements the C++ Tango REST API. It is developed at LHEP JINR to provide web access to Tango devices of the control system... 相似文献
88.
Lozano JM Lesmes LP Carreño LF Gallego GM Patarroyo ME 《Molecules (Basel, Switzerland)》2010,15(12):8856-8889
Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting many synthetic strategies for improving the immunogenicity properties of these sequences, the approach consisting of identifying high binding motifs present in those, and then performing specific changes on amino-acids belonging to such motifs, has proven to be a workable strategy. In addition, other strategies consisting of chemically introducing non-natural constraints to the backbone topology of the molecule and modifying the α-carbon asymmetry are becoming valuable tools to be considered in this pursuit. Non-natural structural constraints to the peptide backbone can be achieved by introducing peptide bond isosters such as reduced amides, partially retro or retro-inverso modifications or even including urea motifs. The second can be obtained by strategically replacing L-amino-acids with their enantiomeric forms for obtaining both structurally site-directed designed immunogens as potential vaccine candidates and their Ig structural molecular images, both having immuno-therapeutic effects for preventing and controlling malaria. 相似文献
89.
V. I. Elkin 《Differential Equations》2018,54(11):1444-1448
The problem of constructing aggregated systems (quotient systems) of the simplest form for nonlinear control systems is considered. This factorization reduces the original control system to a decomposition, which permits one to reduce the dimension of control problems. 相似文献
90.
Verena M. Weiss Toufik Naolou Elkin Amado Karsten Busse Karsten Mder Jrg Kressler 《Macromolecular rapid communications》2012,33(1):35-40
A simple approach using comb‐like polymers that undergo nanophase separation between the polyester backbone and the stearoyl side chains is proposed for the preparation of structured non‐spherical nanoparticles from a nanoemulsion. Depending on the degree of esterification of the OH groups of poly(glycerol adipate) differently ordered nanostructures is obtained. A perfect lamellar arrangement is obtained for polymers with a high degree of esterification and leads to spherical nanoparticles with an internal onion‐like structure. However, when the degree of esterification is only 20 mol%, polygonal nanoparticles with an internal pseudo‐hexagonal structure are obtained. The differences in the nanoparticle shapes are related to the volume fraction of the paraffinic pool. 相似文献