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41.
Gottfried Heinisch Barbara Matuszczak Elisabeth Spielmann Myriam Witvrouw Christophe Pannecouque Erik De Clercq 《Journal of heterocyclic chemistry》2001,38(1):125-130
Two methods for the preparation of dialkylsubstituted dipyridazino[4,3‐b:3′,4′‐e][1,4]diazepinones and dipyridazino[3,4‐b:3′,4′‐e][1,4]diazepinones are reported. The new compounds were evaluated for their inhibitory effects against the replication of human immunodeficiency virus [HIV‐1(IIIB) and HIV‐2(ROD)] in MT‐4 cells. 相似文献
42.
Keller Hildegard Langer Elisabeth Lehner Harald Derflinger Gerhard 《Theoretical chemistry accounts》1978,49(2):93-100
The Algebraic Theory of Chirality Functions is derived by means of exclusively qualitative considerations. Hence, the significance of quantitative results is questionable. Moreover the construction of “Näherungsansätze” (”Approximation-Ansatz”), which may be interpreted as semiempirical methods, is achieved on the basis of plausibility and mathematical simplicity. Since physical arguments are not included, the consistency or inconsistency of “Näherungsansätze” with experimental results do not justify direct physical conclusions. 相似文献
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Quentin Ronzon Dr. Wei Zhang Dr. Nicolas Casaretto Dr. Elisabeth Mouray Prof. Dr. Isabelle Florent Dr. Bastien Nay 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(28):7764-7772
The introduction of substituents on bare heterocyclic scaffolds can selectively be achieved by directed C−H functionalization. However, such methods have only occasionally been used, in an iterative manner, to decorate various positions of a medicinal scaffold to build chemical libraries. We herein report the multiple, site selective, metal-catalyzed C−H functionalization of a “programmed” 4-hydroxyquinoline. This medicinally privileged template indeed possesses multiple reactive sites for diversity-oriented functionalization, of which four were targeted. The C-2 and C-8 decorations were directed by an N-oxide, before taking benefit of an O-carbamoyl protection at C-4 to perform a Fries rearrangement and install a carboxamide at C-3. This also released the carbonyl group of 4-quinolones, the ultimate directing group to functionalize position 5. Our study highlights the power of multiple C−H functionalization to generate diversity in a biologically relevant library, after showing its strong antimalarial potential. 相似文献
45.
Elisabeth Vey Caroline RodgerLiz Meehan Jonathan BoothMike Claybourn Aline F. MillerAlberto Saiani 《Polymer Degradation and Stability》2012,97(3):358-365
We have investigated the in vitro degradation of poly(lactic-co-glycolic) acid copolymer with different lactic to glycolic ratio: 50:50, 65:35, 75:25, 95:05 and 100:00 (mol. %). The degradation studies were performed on solvent cast films of controlled thickness and shape. The samples were incubated at 37 °C in phosphate buffered saline solution. The degradation was followed using potentiometry, light microscopy, gravimetry, size exclusion chromatography and differential scanning calorimetry. The same degradation process, as discussed in detail in our previous article for PLGA 50:50 (E. Vey et al., J. of Polym. Deg. and Stab. 2008, 93, 1896-1876), was observed for all the samples investigated, however the time scale over which the different events/degradation steps were observed increased with increasing lactic content of the polymer. The glass transition temperatures of the films increase with lactic content and are thought to have a significant impact on the rate of diffusion of water into the films - the higher the glass transition the slower the diffusion of water - and therefore on the degradation dynamics of the films. Kinetic parameters were extracted from the acid release, molecular weight and mass loss data. In each case linear correlations between the rate constants extracted and the lactic content of the polymer were found. The overall degradation rate of the films was found to decrease with increasing lactic content. 相似文献
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Spehar AM Koster S Linder V Kulmala S de Rooij NF Verpoorte E Sigrist H Thormann W 《Electrophoresis》2003,24(21):3674-3678
This paper characterizes the basic electrokinetic phenomena occurring within native poly(dimethylsiloxane) (PDMS) microchannels. Using simple buffers and current measurements, current density and electroosmosis data were determined in trapezoidal, reversibly sealed PDMS/PDMS and hybrid PDMS/glass channels with a cross-sectional area of 1035.5 microm(2) and about 6 cm length. This data was then compared to that obtained in an air-thermostated 50 microm inner diameter (1963.5 microm(2) cross-sectional area) fused-silica (FS) capillary of 70 cm length. Having a pH 7.8 buffer with an ionic strength (I) of 90 mM, Ohms's law was observed in the microchannels with electric field strengths of up to about 420 V/cm, which is about twice as high as for the FS capillary. The electroosmotic mobility (micro(EO)) in PDMS and FS is shown to exhibit the same general dependences on I and pH. For all configurations tested, the experimentally determined micro(EO) values were found to correlate well with the relationship micro(EO) = a + b log(I), where a and b are coefficients that are determined via nonlinear regression analysis. Electroosmotic fluid pumping in native PDMS also follows a pH dependence that can be estimated with a model based upon the ionization of silanol. Compared to FS, however, the magnitude of the electroosmotic flow in native PDMS is 50-70% smaller over the entire pH range and is difficult to maintain at acidic pH values. Thus, the origin of the negative charge at the inner wall of PDMS, glass, and FS appears to be similar but the density is lower for PDMS than for glass and FS. 相似文献
48.
Elisabeth Egholm JacobsenErik van Hellemond Anders Riise MoenLucia Camino Vazquez Prado Thorleif Anthonsen 《Tetrahedron letters》2003,44(46):8453-8455
In esterifications of secondary alcohols catalyzed by immobilized lipase B from Candida antarctica (Novozym 435) the E-values decreased during the reaction. Hydrolysis of the corresponding butanoates showed the opposite effect. When an enantiopure (R)-alcohol, related but different, was added to the transesterification reaction, the E-value was significantly enhanced. 相似文献
49.
Denis Ponomarev Elisabeth Rodier Martial Sauceau Clémence Nikitine Vadim Mizonov Jacques Fages 《Journal of mathematical chemistry》2012,50(8):2141-2154
Non-homogeneous velocity distribution of the flow in the channel of a single-screw extruder is taken into account by a new model developed on the basis of the Markov chains. This model allows calculating the Residence Time Distribution (RTD) as well as the influence of the operating conditions on the process at any velocity distribution in the channel. It has been used to represent experimental results on mass flow rate and RTD previously obtained by extrusion of an acrylic polymer, Eudragit E100, at different temperatures and screw rotation speeds. The diffusion coefficient is the only adjusting parameter of the model. It was shown that it does not depend on the screw rotation speed and a correlation between this diffusion coefficient and the barrel temperature was found. The model provides global understanding of the transport kinetics of the flowing material through the extruder according to its behaviour and better describes the progress of the polymer flow all along the barrel from the hopper to the die. 相似文献
50.