全文获取类型
收费全文 | 436篇 |
免费 | 24篇 |
国内免费 | 8篇 |
专业分类
化学 | 225篇 |
晶体学 | 1篇 |
力学 | 4篇 |
数学 | 135篇 |
物理学 | 103篇 |
出版年
2023年 | 3篇 |
2021年 | 2篇 |
2020年 | 11篇 |
2019年 | 3篇 |
2018年 | 8篇 |
2017年 | 2篇 |
2016年 | 9篇 |
2015年 | 10篇 |
2014年 | 3篇 |
2013年 | 17篇 |
2012年 | 23篇 |
2011年 | 18篇 |
2010年 | 13篇 |
2009年 | 10篇 |
2008年 | 18篇 |
2007年 | 32篇 |
2006年 | 21篇 |
2005年 | 21篇 |
2004年 | 21篇 |
2003年 | 19篇 |
2002年 | 22篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 8篇 |
1997年 | 8篇 |
1996年 | 13篇 |
1995年 | 12篇 |
1994年 | 6篇 |
1993年 | 13篇 |
1992年 | 11篇 |
1991年 | 8篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1976年 | 2篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1963年 | 2篇 |
排序方式: 共有468条查询结果,搜索用时 218 毫秒
71.
Dr. Priyadarshi Chakraborty Yiming Tang Dr. Tom Guterman Zohar A. Arnon Yifei Yao Prof. Guanghong Wei Prof. Ehud Gazit 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(52):23939-23947
Supramolecular polymer co-assembly is a useful approach to modulate peptide nanostructures. However, the co-assembly scenario where one of the peptide building blocks simultaneously forms a hydrogel is yet to be studied. Herein, we investigate the co-assembly formation of diphenylalanine (FF), and Fmoc-diphenylalanine (FmocFF) within the 3D network of FmocFF hydrogel. The overlapping peptide sequence between the two building blocks leads to their co-assembly within the gel state modulating the nature of the FF crystals. We observe the formation of branched microcrystalline aggregates with an atypical curvature, in contrast to the FF assemblies obtained from aqueous solution. Optical microscopy reveal the sigmoidal kinetic growth profile of these aggregates. Microfluidics and ToF-SIMS experiments exhibit the presence of co-assembled structures of FF and FmocFF in the crystalline aggregates. Molecular dynamics simulation was used to decipher the mechanism of co-assembly formation. 相似文献
72.
Dr. Mandeep Singh Ephrath Solel Prof. Ehud Keinan Dr. Ofer Reany 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(2):536-540
Semithiobambusurils, which represent a new family of macrocyclic host molecules, have been prepared by a convenient, scalable synthesis. These new cavitands are double functional: they strongly bind a broad variety of anions in their interiors and metal ions at their sulfur‐edged portals. The solid‐state structure of semithiobambus[4]uril with HgCl2 demonstrates the ability of these compounds to form linear chains of coordination polymers with thiophillic metal ions. The crystal structure of semithiobambus[6]uril with tetraphenylphosphonium bromide exhibits the unique anion‐binding properties of the host cavity and the characteristics of the binding site. 相似文献
73.
Lahav M Leiserowitz L 《Angewandte Chemie (International ed. in English)》2008,47(20):3680-2; author reply 3683-6
74.
75.
Ben Shir I Sasmal S Mejuch T Sinha MK Kapon M Keinan E 《The Journal of organic chemistry》2008,73(22):8772-8779
Low-barrier molecular rotary motors having rotaxane architecture can be constructed using a cucurbituril host and a polyyne guest serving as stator and rotator, respectively. The repulsive interaction between these components is supported by molecular mechanics calculations with model systems and experimentally verified by X-ray crystallography with several synthetic host-guest complexes, all suggesting that the diyne rod floats at the center of the macrocyclic host with no apparent van der Waals contacts between them. Further support for these interactions is suggested by microcalorimetry measurements. 相似文献
76.
Here we describe the story behind the link between molecular chirality and macroscopic phenomena, the latter being a probe for the direct assignment of absolute configuration of chiral molecules. First, a brief tour of the history of molecular stereochemistry, starting with the classic experiment reported by Pasteur in 1848 on the separation of enantiomorphous crystals of a salt of tartaric acid, and his conclusion that the molecules of life are chiral of single-handedness. With time, this study raised, inter alia, two fundamental questions: the absolute configuration of chiral molecules and how a molecule of given configuration shapes the enantiomorphous morphology of its crystal. As for the first question, following the beginning of crystal structure determination by X-ray diffraction in 1912, it took almost 40 years before Bijvoet assigned molecular chirality through the esoteric method involving anomalous X-ray scattering. We have been able to address and link both questions through ‘everyday concepts of left and right’ (in the words of Jack Dunitz) by the use of ‘tailor-made’ auxiliaries. By such means, it proved possible to reveal, through morphology, etch patterns, epitaxy and symmetry reduction of both chiral and, paradoxically, centrosymmetric crystals, the basic chiral symmetry of the molecules of life, the α-amino acids and sugars. 相似文献
77.
We determine the asymptotic behavior of the expected value and the variance of the log-product of the subtree-sizes of trees Tn belonging to simply generated families of rooted trees. © 1998 John Wiley & Sons, Inc. Random Struct. Alg., 12, 197–212, 1998 相似文献
78.
Let k be a fixed integer and fk(n, p) denote the probability that the random graph G(n, p) is k‐colorable. We show that for k≥3, there exists dk(n) such that for any ϵ>0, (1) As a result we conclude that for sufficiently large n the chromatic number of G(n, d/n) is concentrated in one value for all but a small fraction of d>1. ©1999 John Wiley & Sons, Inc. Random Struct. Alg., 14, 63–70, 1999 相似文献
79.
Anat Frydman‐Marom Meirav Rechter Irit Shefler Yaron Bram Deborah E. Shalev Dr. Ehud Gazit Prof. 《Angewandte Chemie (International ed. in English)》2009,48(11):1981-1986
A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid‐β polypeptide (Aβ) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique Cα‐methylation β‐breakage strategy. The electrostatic potential of the low‐energy conformation of the dipeptide inhibitor bound to Aβ is shown.
80.
Zhen-Dan Shi Omid Motabar Ehud Goldin Ke Liu Noel Southall Ellen Sidransky Christopher P. Austin Gary L. Griffiths Wei Zheng 《Analytical and bioanalytical chemistry》2009,394(7):1903-1909
Alpha-galactosidase A hydrolyzes the terminal alpha-galactosyl moieties from glycolipids and glycoproteins in lysosomes. Mutations
in α-galactosidase cause lysosomal accumulation of the glycosphingolipid, globotriaosylceramide, which leads to Fabry disease.
Small-molecule chaperones that bind to mutant enzyme proteins and correct their misfolding and mistrafficking have emerged
as a potential therapy for Fabry disease. We have synthesized a red fluorogenic substrate, resorufinyl α-d-galactopyranoside, for a new α-galactosidase enzyme assay. This assay can be measured continuously at lower pH values, without
the addition of a stop solution, due to the relatively low pK
a of resorufin (~6). In addition, the assay emits red fluorescence, which can significantly reduce interferences due to compound
fluorescence and dust/lint as compared to blue fluorescence. Therefore, this new red fluorogenic substrate and the resulting
enzyme assay can be used in high-throughput screening to identify small-molecule chaperones for Fabry disease.
Zhen-Dan Shi and Omid Motabar contributed equally to this work 相似文献