Blood flow dynamics and fluid–structure interaction in patient‐specific bifurcating cerebral aneurysms

Hemodynamics plays an important role in the progression and rupture of cerebral aneurysms. The current work describes the blood flow dynamics and fluid–structure interaction in seven patient‐specific models of bifurcating cerebral aneurysms located in the anterior and posterior circulation regions of the circle of Willis. The models were obtained from 3D rotational angiography image data, and blood flow dynamics and fluid–structure interaction were studied under physiologically representative waveform of inflow. The arterial wall was assumed to be elastic, isotropic and homogeneous. The flow was assumed to be laminar, non‐Newtonian and incompressible. In one case, the effects of different model suppositions and boundary conditions were reported in detail. The fully coupled fluid and structure models were solved with the finite elements package ADINA. The vortex structure, pressure, wall shear stress (WSS), effective stress and displacement of the aneurysm wall showed large variations, depending on the morphology of the artery, aneurysm size and position. The time‐averaged WSS, effective stress and displacement at the aneurysm fundus vary between 0.17 and 4.86 Pa, 4.35 and 170.2 kPa and 0.16 and 0.74 mm, respectively, for the seven patient‐specific models of bifurcating cerebral aneurysms. Copyright © 2008 John Wiley & Sons, Ltd.     

A note on the minmax regret centdian location on trees

The minmax regret optimization model of the doubly weighted centdian location on trees is considered. Assuming that both types of weights, demands and relative importance of the customers, are partially known through interval estimates, an exact algorithm of complexity O(n³logn) is derived. This bound is improved in some special cases.     

The Operators of Vector Logic

Vector logic is a mathematical model of the propositional calculus in which the logical variables are represented by vectors and the logical operations by matrices. In this framework, many tautologies of classical logic are intrinsic identities between operators and, consequently, they are valid beyond the bivalued domain. The operators can be expressed as Kronecker polynomials. These polynomials allow us to show that many important tautologies of classical logic are generated from basic operators via the operations called Type I and Type II products. Finally, it is described a matrix version of the Fredkin gate that extends its properties to the many-valued domain, and it is proved that the filtered Fredkin operators are second degree Kronecker polynomials that cannot be generated by Type I or Type II products. Mathematics Subject Classification: 03B05, 03B50.     

Respiratory modulation of heart beat-to-beat interval in diabetic patients

We have analyzed simultaneous recordings of respiration and heartbeat intervals in diabetic patients and control subjects. Our main findings are that in diabetic patients the heart beat-to-beat interval variability and cardiorespiratory crosscorrelation are decreased, the autocorrelation time of the interval series is increased, and the phase relation of the respiration with the heartbeat interval oscillations is often reversed in comparison with the control subjects. We have been able to reproduce the data using a biophysical model in which the time dependent input signal to the sinoatrial node was constituted of quasiperiodic and aperiodic components. The quasiperiodic input was obtained from the recording of the respiratory signal and the aperiodic input was obtained from selected realizations of correlated noise. Our study indicates that both input components to the sinoatrial node are modified in diabetic patients.     

Convolution quadrature time discretization of fractional diffusion-wave equations

We propose and study a numerical method for time discretization of linear and semilinear integro-partial differential equations that are intermediate between diffusion and wave equations, or are subdiffusive. The method uses convolution quadrature based on the second-order backward differentiation formula. Second-order error bounds of the time discretization and regularity estimates for the solution are shown in a unified way under weak assumptions on the data in a Banach space framework. Numerical experiments illustrate the theoretical results.

     

A sharp global stability result for a discrete population model

We get a sharp global stability result for a first order difference equation modelling the growth of bobwhite quail populations. The corresponding higher-dimensional model is also discussed, and our stability conditions improve other recent results for the same equation.     

Optimization of a heart-cutting multidimensional gas chromatography-based method for the assessment of enantiomeric fractions of o,p′-DDT in environmental samples

The enantiomeric fractions present in soil samples may provide information useful in distinguishing recent inputs of DDT from past DDT pollution. In this study, a chromatographic procedure for the determination of the enantiomeric fractions of o,p′-DDT based on heart-cutting multidimensional gas chromatography was developed. The optimization carried out achieved low ratios of DDT degradation (<15%) in the chromatographic system. High selectivity and sensitivity in the detection of the target compounds, with a limit of detection as low as 2.1 pg μL⁻¹, was reached. In addition, high degrees of repeatability (RSD < 2.0%) and reproducibility (RSD < 3.2%) were obtained for the enantiomeric fractions measured in analytical standards and soil samples.