Novel functional hyperbranched polyether polyols as prospective drug delivery systems

Multifunctional hyperbranched polyether polyols bearing protective poly(ethylene glycol) (PEG) chains with or without the folate targeting ligand at their end have been prepared. Solubilization in these polymers of a fluorescent probe, pyrene, and an anticancer drug, tamoxifen, was physicochemically investigated. It was found that PEG chains attached at the surface of these hyperbranched polymers, in addition to their well-established protective role, enhance the encapsulation efficiency of the polymers. The release of pyrene and tamoxifen observed upon addition of sodium chloride is, in most of the cases, significant only at concentrations exceeding the physiological extracellular concentration. Thus, a significant amount of the probe or drug remains solubilized inside the carriers, which is an encouraging result if the polymers are to be used for drug delivery.     

Quantum mechanical study of the correlation of attack and recoil angles for the Cl + H2 reaction using the stereodirected and discrete variable representations on two potential energy surfaces

The zero total angular momentum (J = 0) S matrix elements, calculated using a time-dependent wave packet method for the Cl (2P) + H2 reaction on two different potential energy surfaces, have been matrix transformed to the stereodirected and Gauss-Legendre discrete variable representations. Although the results in the two representations are (as expected) quantitatively different with respect to the angular selectivity and specificity of the reactive process, the qualitative similarity has allowed us to draw for the first time conclusions with respect to some characteristics of the potential energy surface.     

Multilayer metal/metal-oxide diffractive structure for photonic temperature sensing

We designed and fabricated multilayer metal/metal-oxide surface relief diffractive grating structures by growing alternating Pt and SnO(x) layers. Optical interrogation at 633 nm reveals the temperature dependence of their reflection and transmission diffractive effects. This function is explored here in the context of a remote, spatially localized, photonic temperature sensing operation, achieving sensitivity of 10% per °C for the zeroth-order in the transmission mode. The experimental demonstration is found to be in good agreement with the results of rigorous coupled wave analysis of the composite metal/metal-oxide element.     

Data-driven robust optimization

Mathematical Programming - The last decade witnessed an explosion in the availability of data for operations research applications. Motivated by this growing availability, we propose a novel schema...     

Characteristic parameter sets and limits of circulant Hermitian polygon transformations

Polygon transformations based on taking the apices of similar triangles constructed on the sides of an initial polygon are analyzed as well as the limit polygons obtained by iteratively applying such transformations. In contrast to other approaches, this is done with respect to two construction parameters representing a base angle and an apex perpendicular subdivision ratio. Furthermore, a combined transformation leading to circulant Hermitian matrices is proposed, which eliminates the rotational effect of the basic transformation. A finite set of characteristic parameter subdomains is derived for which the sequence converges to specific eigenpolygons. Otherwise, limit polygons turn out to be linear combinations of up to three eigenpolygons. This leads to a full classification of circulant Hermitian similar triangles based polygon transformations and their limit polygons. As a byproduct classical results as Napoleon’s theorem and the Petr-Douglas-Neumann theorem can be easily deduced.     

Robust and data-driven approaches to call centers

We propose both robust and data-driven approaches to a fluid model of call centers that incorporates random arrival rates with abandonment to determine staff levels and dynamic routing policies. We test the resulting models with real data obtained from the call center of a US bank. Computational results show that the robust fluid model is significantly more tractable as compared to the data-driven one and produces overall better solutions to call centers in most experiments.     

Evaluation of credit risk based on firm performance

This paper investigates whether productive inefficiency measured as the distance from the industry’s ‘best practice’ frontier is an important ex-ante predictor of business failure. We use samples of French textiles, wood and paper products, computers and R&D companies to obtain efficiency estimates for individual firms in each industry. These efficiency measures are derived from a directional technology distance function constructed empirically using non-parametric data envelopment analysis (DEA) methods. Estimating binary and ordered logit regression models we find that productive efficiency has significant explanatory power in predicting the likelihood of default over and above the effect of standard financial indicators.     

The spectrum of the random environment and localization of noise

We consider random walk on a mildly random environment on finite transitive d-regular graphs of increasing girth. After scaling and centering, the analytic spectrum of the transition matrix converges in distribution to a Gaussian noise. An interesting phenomenon occurs at d = 2: as the limit graph changes from a regular tree to the integers, the noise becomes localized. The graphs of the noise covariance structure for d = 4, 3, 2.1 from above.     

On multiplicative functions which are small on average

Let f be a completely multiplicative function that assumes values inside the unit disc. We show that if ${\sum_{n \leq x}f(n)\ll x/(\rm log x)^A}$ ∑ n ≤ x f ( n ) ? x / ( l o g x ) A , ${x \geq 2}$ x ≥ 2 , for some A > 2, then either f(p) is small on average or f pretends to be ${\mu(n)n^{it}}$ μ ( n ) n i t for some t.     

Updating Insights into the Catalytic Domain Properties of Plant Cellulose synthase (CesA) and Cellulose synthase-like (Csl) Proteins

The wall is the last frontier of a plant cell involved in modulating growth, development and defense against biotic stresses. Cellulose and additional polysaccharides of plant cell walls are the most abundant biopolymers on earth, having increased in economic value and thereby attracted significant interest in biotechnology. Cellulose biosynthesis constitutes a highly complicated process relying on the formation of cellulose synthase complexes. Cellulose synthase (CesA) and Cellulose synthase-like (Csl) genes encode enzymes that synthesize cellulose and most hemicellulosic polysaccharides. Arabidopsis and rice are invaluable genetic models and reliable representatives of land plants to comprehend cell wall synthesis. During the past two decades, enormous research progress has been made to understand the mechanisms of cellulose synthesis and construction of the plant cell wall. A plethora of cesa and csl mutants have been characterized, providing functional insights into individual protein isoforms. Recent structural studies have uncovered the mode of CesA assembly and the dynamics of cellulose production. Genetics and structural biology have generated new knowledge and have accelerated the pace of discovery in this field, ultimately opening perspectives towards cellulose synthesis manipulation. This review provides an overview of the major breakthroughs gathering previous and recent genetic and structural advancements, focusing on the function of CesA and Csl catalytic domain in plants.