Phosphoryl chloride induced ring contraction of 1,4-benzodiazepinones to chloromethylquinazolines

A ring contraction of 1,4-benzodiazepin-2-one to 2-chloromethylquinazoline in phosphoryl chloride is described. The intermediacy of an aziridinoquinazoline is proposed.     

Germanium

Ohne Zusammenfassung     

Highly stereoselective reduction of methyl ketone complexes of the chiral Lewis acid [(η-C5H5)Re(NO)(PPh3)] by K(s-C4H9)3BH; synthesis of optically active secondary alcohols and derivatives

Reaction of optically active ketone complexes (+)-(R)-[(η⁵-C₅H₅)Re(NO)-(PPh₃)(η¹-O=C(R)(CH₃)]⁺ BF₄⁻ (R = CH₂CH₃, CH(CH₃)₂m C(CH₃)₃, C₆H₅) with K(s-C₄H₉)₃BH gives alkoxide complexes (+)-(RS)-(η⁵-C₅H₅)Re(NO)(PPh₃)-(OCH(R)CH₃) (73–90%) in 80–98% de. The alkoxide ligand is then converted to Mosher esters (93–99%) of 79–98% de.     

Lariat ethers. VI. Evidence for intramolecular chelation in sodium and potassium cation binding by 15-crown-5, carbon-pivot lariat ethers

The first compelling evidence for intramolecular sidearm involvement in sodium and potassium cation complexation by carbon-pivot lariat ethers is presented.     

Synthesis of (4.5.5.5]fenestrane and a [4.4.5.5]fenestrane derivative

The synthesis of tetracyclo[5.4.1.0^4,12.0^9.12]dodecan-6-one $\text{12}$ via an intramolelecular photocycloaddition, its reduction to the hydrocarbon $\text{13}$ and its ring-contraction to tetracyclo-[4.4.1.0^3,11.0^9,11]undecane derivative $\text{16}$ is described.