全文获取类型
收费全文 | 184篇 |
免费 | 7篇 |
国内免费 | 2篇 |
专业分类
化学 | 117篇 |
力学 | 5篇 |
数学 | 40篇 |
物理学 | 31篇 |
出版年
2023年 | 1篇 |
2022年 | 8篇 |
2021年 | 4篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 8篇 |
2017年 | 3篇 |
2016年 | 10篇 |
2015年 | 12篇 |
2014年 | 10篇 |
2013年 | 12篇 |
2012年 | 18篇 |
2011年 | 22篇 |
2010年 | 17篇 |
2009年 | 8篇 |
2008年 | 8篇 |
2007年 | 6篇 |
2006年 | 5篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 5篇 |
2002年 | 2篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1986年 | 1篇 |
排序方式: 共有193条查询结果,搜索用时 46 毫秒
61.
62.
During preformulation studies of pharmaceutical solid dosage forms, thermal analysis techniques are very useful to detect
physical or chemical incompatibilities between the drug and adjuvants of interest that might interfere with efficacy and safety
of the final drug product. Differential scanning calorimetry (DSC) and thermogravimetry (TG) are useful tools for this purpose.
The aim of this study was to investigate the thermoanalytical behavior of olanzapine (OLZ) when mixed with several excipients
commonly used in solid dosage forms such as microcrystalline cellulose, croscarmellose, dicalcium phosphate dihydrate (DCPD),
lactose, magnesium stearate, and povidone. Following DSC and TG analyses, powder X-ray diffraction tests were carried out.
Thermoanalytical methods showed evidence of interaction between OLZ and magnesium stearate, lactose, and povidone. These results
can be useful during the selection of excipients for pharmaceutical formulation development. 相似文献
63.
Milan Randić Damir Vukičević Alexandru T. Balaban Marjan Vračko Dejan Plavšić 《Journal of computational chemistry》2012,33(11):1111-1122
We report on calculated CC bond currents for a dozen derivatives of hexabenzocoroenene in which one or more proximal carbon atoms at the molecular periphery have been bridged. The approach that we use is graph‐theoretical in nature, following our outline of this method in 2003, which is based on finding all conjugated circuits in all Kekulé valence structures of these molecules. To the π‐electrons having 4n + 2 π‐electrons are assigned anticlockwise π‐electron currents and to conjugated circuits having 4n π‐electrons are assigned π‐electron currents. One may summarize the results reported in this work by stating that CC bond currents in the compounds considered decrease on going from peripheral rings to the central ring of the molecule, and also that CC bond currents decrease by insertion of bridges to proximal peripheral benzenoid rings. © 2012 Wiley Periodicals, Inc. 相似文献
64.
Maja ?umar Ristovi? Maja Gruden Pavlovi? Matija Zlatar Vladimir Blagojevi? Katarina An?elkovi? Dejan Poleti Dragica M. Mini? 《Monatshefte für Chemie / Chemical Monthly》2012,107(3):1133-1139
Abstract
A Zn(II) complex with N-benzyloxycarbonylglycinato ligands was studied by non-isothermal methods, in particular Kissinger–Akahira–Sunose’s method, and further analysis of these results was performed by Vyazovkin’s algorithm and an artificial compensation effect. Density functional theory calculations of thermodynamic quantities were performed, and results obtained by both methods are consistent, thus clarifying the mechanism of this very interesting multi-step degradation. 相似文献65.
Colloidal interactions between proteins determine the behavior and stability of globular proteins such as monoclonal antibodies (mAbs) against their propensity to cluster formation in solution. We study interactions between these proteins through their dilute solution behavior. Experiments to quantify intermolecular interactions were done using Dynamic and Static Light Scattering (DLS and SLS) in a high-throughput manner in parallel with zeta potential measurements with Laser Doppler Electrophoresis method (M3-PALS). This approach offers a rapid indirect determination of colloidal interactions through their measured second virial coefficient. Electrostatic part of the DLVO interaction was conveniently parameterized via the corresponding surface charge and/or surface potential, while the van der Waals interactions were parameterized via their Hamaker coefficient, both as functions of ionic strength and pH of the bathing solution. This parametrization of protein-protein interactions improves our understanding of mAb assembly and provides a means for its control by solution parameter variation. Additionally, our results also provide a consistency check and validation of applicability of the DLVO theory in mAbs solution assembly processes. 相似文献
66.
67.
Slobodan M. Vuković Najdan B. Aleksić Dejan V. Timotijević Milivoj R. Belic 《Optics Communications》2012,285(6):1148-1154
We studied electromagnetic wave transmission through layered structures that include negative index materials. The excitation of leaky guided modes leads to the formation of anomalous lateral shifts in the reflected beam with a double-peak structure and in the transmitted beam with a single-peak structure. In the absence of losses, we demonstrate that the total transparency (i.e. zero reflection) of the slab waveguide with the negative index material can be achieved under conditions in which high reflectivity is normally expected. We demonstrate the trade-off effect between the high transmission and the high lateral shift. This peculiar effect exists not only for the pure TE or the pure TM polarization of the obliquely incident radiation, but also under certain circumstances for both of them simultaneously i.e. for the nonpolarized radiation. 相似文献
68.
We present a theoretical analysis of the image formation in structured illumination wide-field fluorescence microscopy (SIWFFM). We show that the optically sectioned images obtained with this approach possess the optical sectioning strengths comparable to those obtained with the confocal microscope. We further show that the transfer function behaviour is directly comparable to that of the true confocal instrument. The theoretical considerations are compared with and confirmed by experimental results. 相似文献
69.
Vesna Rastija Karolina Vrande
i Jasenka osi Gabriella Kaniai ari Ivana Maji Dejan Agi Domagoj ubari Maja Karna Drago Belo Mario Komar Maja Molnar 《Molecules (Basel, Switzerland)》2022,27(7)
Coumarin derivatives have been reported as strong antifungal agents against various phytopathogenic fungi. In this study, inhibitory effects of nine coumarinyl Schiff bases were evaluated against the plant pathogenic fungi (Fusarium oxysporum f. sp. lycopersici, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiourum). The compounds were demonstrated to be efficient antifungal agents against Macrophomina phaseolina. The results of molecular docking on the six enzymes related to the antifungal activity suggested that the tested compounds act against plant pathogenic fungi, inhibiting plant cell-wall-degrading enzymes such as endoglucanase I and pectinase. Neither compound exhibited inhibitory effects against two beneficial bacteria (Bacillus mycoides and Bradyrhizobium japonicum) and two entomopathogenic nematodes. However, compound 9 was lethal (46.25%) for nematode Heterorhabditis bacteriophora and showed an inhibitory effect against acetylcholinesterase (AChE) (31.45%), confirming the relationship between these two activities. Calculated toxicity and the pesticide-likeness study showed that compound 9 was the least lipophilic compound with the highest aquatic toxicity. A molecular docking study showed that compounds 9 and 8 bind directly to the active site of AChE. Coumarinyl Schiff bases are promising active components of plant protection products, safe for the environment, human health, and nontarget organisms. 相似文献
70.