聚氨酯分子印章的制备和表征

“软平板印刷”微结构制备技术为微米和亚微米器件的制备提供了一条新的途径 [1] ,已被电子学家和材料学家所应用 ,近年来进入了生物学领域[2 ] .本实验室将这一方法与生物分子电子学相结合 ,提出了用于 DNA芯片在片合成的分子印章法 [3,4 ] .分子印章法的实质是接触压印与组合化学相结合的固相界面反应 .聚二甲氧基硅氧烷 ( PDMS)是一种软印刷的优良材料 [5] ,但是由于其疏水性和较差的机械性能 ,必须对其进行改性才能用来制备 DNA分子印章 [6 ] .　　聚氨酯作为一种功能材料 ,由于分子中交替的软、硬链段及其不同的热动力学性能而形成…     

Ga3(HPO3)4F4(H3DETA) (DETA=diethylenetriamine): A new open-framework fluorinated gallium phosphite with pentameric building unit

Ga₃(HPO₃)₄F₄(H₃DETA) is a new open-framework fluorinated gallium phosphite obtained by mild hydrothermal synthesis using diethylenetriamine as templated agent and characterized by single crystal X-ray diffraction, the powder X-ray diffraction, IR spectroscopy, TGA, ICP and elemental analyses. It crystallizes in the monoclinic space group C2/c, a=12.741(6) Å, b=12.068(6) Å, c=11.988(5) Å, β=94.902(8)^o, V=1836.6(15) Å³, Z=4. The construction of 3D open-framework structure in the title compound may be viewed as the assembly of pentameric building units and HPO₃ groups. The pentameric building unit is the first to be found, which lead to form the three types of channels along a-, b- and c-axes, respectively, in gallium phosphite. The triprotonated DETA cations are inserted within the 10-membered ring channels and interact with anions of the framework via hydrogen bonds.     

Lancifodilactone G: a unique nortriterpenoid isolated from Schisandra lancifolia and its anti-HIV activity

[structure: see text]. Lancifodilactone G (1), a novel, highly oxygenated nortriterpenoid featuring a partial enol structure and a spirocyclic moiety, was isolated from the medicinal plant Schisandra lancifolia. Its structure and stereochemistry were determined from extensive one- and two-dimensional NMR and mass spectral data, coupled with single-crystal X-ray analysis. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and showed anti-HIV activity with EC50 = 95.47 +/- 14.19 microg/mL and a selectivity index in the range of 1.82-2.46.     

Synthesis,Structure and Adsorption of AlPO-21 Prepared by Co-template Method

IntroductionAlPO 2 1isatypeofmicroporousaluminophosphatepreparedbyFlanigenandco workersin 1982 ,andthestructurewasresolvedbySmithetal.1in 1984 .AlmostatthesametimePariseetal.2 preparedAlPO 2 1phasebyanotherrouteandresolvedthestructureindependently .Inthenextyear ,GaPO 2 1phasewasobtainedaswell.3Al thoughAl(Ga)PO 2 1phasespreparedindifferentwayspossesssimilarchannelsystem ,amongthemtherearestillsomedifferencesinlatticeconstants ,indicatingthatdiffer enttemplatemoleculescanaffectlocallythe…     

A novel synthesis of allyl and propargyl selenides in aqueous media promoted by indium

Allylic and propargyl bromides react smoothly with diorganyl diselenides in aqueous media to give allylic and propargyl selenides in moderate to good yields. The reaction need not be carried out in inert atmosphere. The speed is quicker than the same reactions in organic media.     

亚磺化脱卤试剂在有机合成中的应用

本文综述了亚磺化脱卤试剂在有机合成中的应用。特别是氟烷基化反应中的应用。     

A facile synthesis of bifunctional phospholipids for biomimetic membrane engineering

We report a facile synthesis of bifunctional phospholipid conjugates by acylation of N-protected lyso-phosphatidylethanolamine with 12-acryloxy-1-dodecanoic acid and followed with deprotection and conjugation with biotin, FITC, Texas Red, or EMC groups. The lipid conjugates can be used to generate a multifunctional substrate-supported phospholipid membrane via bioconjugation reaction to biotin or covalent attachment to EMC at their hydrophilic terminus. In addition, conjugation to fluorophores, FITC or Texas Red, provides a convenient mechanism to monitor lipid membrane formation and stability. Significantly, in situ photopolymerization of the acrylate group at the end of one of two hydrophobic alkyl chains stabilizes the phospholipid membrane.     

A novel route to nanosized molybdenum boride and carbide and/or metallic molybdenum by thermo-synthesis method from MoO3, KBH4, and CCl4

Nanosized molybdenum boride and carbide were synthesized from MoO₃, KBH₄, and CCl₄ by thermo-synthesis method at lower temperature. The relative content of Mo, Mo₂C, and molybdenum boride in the product was decided by the molar ratio between MoO₃, KBH₄, and CCl₄. Increasing the molar ratio of CCl₄ to MoO₃ was favorable to the production of Mo₂C. Increasing the molar ratio of KBH₄ to MoO₃ was favorable to the production of molybdenum boride. By carefully adjusting the reaction conditions and annealing in Ar at 900°C, a single phase of MoB could be obtained.     

化合物库的组合技巧和组合合成

从化合物库的组合技巧和组合合成方法两个方面探讨了组合化学及其在药物开发中的应用。