On a parabolic–elliptic chemotactic model with coupled boundary conditions

This paper deals with a nonlinear system of parabolic–elliptic type with a logistic source term and coupled boundary conditions related to pattern formation. We prove the existence of a unique positive global in time classical solution. We also analyze the associated stationary problem. Moreover it is proved, under the assumption of sufficiently strong logistic damping, that there is only one nonzero homogeneous equilibrium, and all the solutions to the nonstationary problem tend to this steady state for large times.     

Thermo-hydraulic characterization of a louvered fin and flat tube heat exchanger

In the present study, a whole heat exchanger with a hydraulic diameter of 2.3 mm is tested, which is a minichannel heat exchanger according to the Kandlikar classification. This is a louvered fin and flat tube heat exchanger currently used in car cooling systems, also known as radiator. A glycol-water mixture (60/40 in volume) circulates through the tubes at flows ranging from 100 to 7800 l/h and at a supply temperature of 90 °C. This fluid is cooled with ambient air at a temperature of 20 °C and at frontal air velocities varying between 0.5 and 7 m/s. The thermohydraulic performance of the heat exchanger is compared with the classical correlations given in the literature for the heat transfer and the friction factor calculation. On the glycol-water side the heat exchanger is characterized for Reynolds numbers from 30 to 8000. A first comparison is carried out with the correlations available in the literature with a purely predictive model by obtaining a predictive value with a systematic under prediction lower than 10%. In a second step a semi-empirical model is considered to identify the experimental heat transfer coefficients for this application.     

Synthesis of Small‐Molecule Fluorescent Probes for the In Vitro Imaging of Calcium‐Activated Potassium Channel KCa3.1

Small‐molecule probes for the in vitro imaging of K_Ca3.1 channel‐expressing cells were developed. Senicapoc, showing high affinity and selectivity for the K_Ca3.1 channels, was chosen as the targeting component. BODIPY dyes 15 – 20 were synthesized and connected by a Cu^I‐catalyzed azide–alkyne [3+2]cycloaddition with propargyl ether senicapoc derivative 8 , yielding fluorescently labeled ligands 21 – 26 . The dimethylpyrrole‐based imaging probes 25 and 26 allow staining of K_Ca3.1 channels in NSCLC cells. The specificity was shown by removing the punctate staining pattern by pre‐incubation with senicapoc. The density of K_Ca3.1 channels detected with 25 and by immunostaining was identical. The punctate structure of the labeled channels could also be observed in living cells. Molecular modeling showed binding of the senicapoc‐targeting component towards the binding site within the ion channel and orientation of the linker with the dye along the inner surface of the ion channel.     

Rare earth doped cobalt ferrite thin films deposited by PLD

CoFe₂O₄ thin films with preferential texture structure, small grain size, and perpendicular magnetic anisotropy can be obtained by the pulsed laser deposition (PLD) technique. In this work, we studied the influence of the Fe³⁺ ions substitution by three elements from lanthanide group (Dy, La, and Gd) on the structural properties of the thin films. The samples were deposited by Nd:YAG laser (λ=532 nm, 10 ns) ablation of CoFe_1.8RE_0.2O₄, (RE=Dy, La, Gd) targets at various substrate temperatures ranging from room temperature to 600 °C. The microstructure and chemical composition of the thin films were investigated by Raman spectroscopy, XRD, SEM-EDS, and ToF-SIMS. The XRD patterns and Raman spectra of the thin films indicated the formation of a single spinel structure. Thus, the desired substitution of the iron ions in the spinel lattice with the RE elements was achieved in the thin films, although in the bulk material, their presence determined the formation of a residual phase with a perovskite-type structure.     

Edge-enhanced imaging with polyvinyl alcohol/acrylamide photopolymer gratings

We demonstrate edge-enhanced imaging produced by volume phase gratings recorded on a polyvinyl alcohol/acrylamide photopolymer. Bragg diffraction, exhibited by volume gratings, modifies the impulse response of the imaging system, facilitating spatial filtering operations with no need for a physical Fourier plane. We demonstrate that Kogelnik's coupled-wave theory can be used to calculate the transfer function for the transmitted and the diffracted orders. The experimental and simulated results agree, and they demonstrate the feasibility of our proposal.