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81.
The cellular mechanism based on P-glycoprotein (PGP) for its drug pump function has become very important in multidrug resistance (MDR) research. A method has been established to characterize PGP on single K562 cell by coupling capillary electrophoresis with laser induced fluorescence detection. A permeable intact cell after the immunoassay binding with fluorescence labeling antibody was injected into the capillary and directly separated without lysis. It was found that once 5-10 optional cells were detected in batch, the PGP amount on this cell line could be outlined and calculated clearly. The PGP amount on K562 MDR cell line is 3.88 times higher than that on K562 sensitive cell line. These two cell lines with immunoassay binding were also analyzed by injection of multi-cells in order to improve the throughput. A resistance factor so called multidrug resistance multiple (MRM) was introduced to evaluate the MDR difference between cell lines. The MRM values of the cell line K562 measured by single cell analysis are well correlated with those by flow cytometry, which also prove the validity of our method in single cell analysis for the possibility of cancer diagnosis, pharmacokinetics and drug screening in future. 相似文献
82.
Desmond A. Young Daneel Ferreira David G. Roux 《Journal of polymer science. Part A, Polymer chemistry》1986,24(5):835-849
The structure and stereochemistry of four synthetic “angular” tetraflavanoid-condensed tannin derivatives are examined by high-resolution variable temperature 1H NMR. spectroscopy, and hence correlated with their dynamic behavior. Three “angular” oligomers exist as stable rotational isomers at ambient temperatures, thus contrasting with the mobility about their interflavanoid bonds of most natural profisetinidin “trimeric” and “tetrameric” homologs. A “linear” tetraflavanoid analog results from one of these regioselectively controlled condensations. 相似文献
83.
The association of a C3v-symmetrical calix[6]tris-amine with different concave tris-carboxylic acids of various degrees of flexibility has been explored by 1H NMR spectroscopy. In all cases, self-assembled structures directed by the selective inclusion of a neutral guest molecule were obtained, the more preorganized being stable in protic solvents. With a rigid C3-symmetrical cap, chiral guest recognition in the calixarene cavity resulted. A large tris-acidic partner gave a unique molecular ditopic receptor that is able to simultaneously accommodate two neutral molecules in two distinct hydrophobic cavities with different binding processes. 相似文献
84.
Perfluoromethyl Element Ligands. XXIX. Preparation and Spectroscopic Investigation of M(CO)4L2 Complexes (M ? Cr, Mo, W; L ? Me2PSMe, Me2PSeMe, (CF3)2PSMe, (CF3)2PSMe) The complexes M(CO)4L2 (see Inhaltsübersicht) have been prepared by the reaction of tetracarbonyl norbornadiene metal compounds M(CO)4NBD with L at room temperature or 35°C, respectively. The cis-complexes formed in the first step undergo rearrangement to trans-isomers at higher temperatures. New compounds have been characterized by analytical and spectroscopic (IR, NMR, MS) methods. 相似文献
85.
This review covers our extensive research activities in the area of fluorine containing phospha- and arsaalkenes as well as selenocarbonyls, which differ considerably in their properties and reactivities from their alkyl and aryl counterparts and thus contribute in a gratifying manner to the still growing field of unsaturated element-carbon compounds of 3rd and 4th row main group elements E. Of particular interest is the influence of the fluorine substituents and other small groups (OR, NR2) with either inductive and/or mesomeric effects on the polarity and reactivity of the EC bond. Addition reactions of proton acidic and hydridic polar HX reactants as well as [2+2], [3+2] and [4+2] cycloadditions have been thoroughly studied. The results obtained allow a classification of the EC systems within five different types, A to E, and prove a change from “normal” to “inverse” heteroalkenes in this sequence. The ligand properties of some derivatives have also been investigated in some detail. 相似文献
86.
87.
Haberichter T Roux E Marhl M Mazat JP 《Bioelectrochemistry (Amsterdam, Netherlands)》2002,57(2):129-138
In airway myocytes, like in many cells, Ca(2+) signaling is controlled by inositol 1,4,5-trisphosphate (InsP(3)) via InsP(3) receptors (InsP(3)R) located in the sarco-endoplasmic reticulum. Three types of InsP(3)R exist, labeled Types 1, 2, and 3, which differ in their gating kinetics. We analyze a possible impact of the different gating kinetics of Type 1 and Type 3 InsP(3)R on the time course of cytosolic Ca(2+) concentration in tracheal smooth muscle cells upon agonist stimulation. Previous experimental data in rat tracheal myocytes showed that upon gradually increased stimulation with acetylcholine (ACh), a contractile agonist that acts via InsP(3) production, signal spikes, several spikes with declining maxima, and sustained oscillations appear. Our model reproduces the time courses of cytosolic Ca(2+) measured in tracheal myocytes. Moreover, by postulating slight variations in the model parameters which determine the total number of receptors expressed and the ratio between Type 1 and Type 3 InsP(3)R, it offers an explanation to the experimental observation of qualitatively different responses of cells within a presumably homogeneous tissue. 相似文献
88.
Thierry Le Borgne Pierre Thury Michel Ephritikhine 《Acta Crystallographica. Section C, Structural Chemistry》2002,58(1):m8-m9
The ligand 1,2,3,4‐tetramethyl‐5‐(2‐pyridyl)cyclopentadiene (cp*py) forms a dinuclear complex with UIV, i.e. di‐μ‐oxo‐bis{chloro(diethyl ether‐κO)[(η5,κN)‐1,2,3,4‐tetramethyl‐5‐(2‐pyridyl)cyclopentadienyl]uranium(IV)}, [U2Cl2O2(C14H16N)2(C4H10O)2], in which cp*py acts as a chelating ligand, being bound to the metal atom by the cyclopentadienyl unit and also by the N atom of the pyridyl ring. 相似文献
89.
Syntheses of new sulfinylcinnolines, quinoxalines, quinazolines and phtalazines have been investigated starting from the appropriate halogenobenzodiazine derivatives. The latter were converted in one step to the corresponding sulfanyl benzodiazines which upon oxidation with m-CPBA led to the corresponding sulfoxide derivatives of benzodiazines in moderate to good yields. In parallel to this study, an improved method for the synthesis of 2-methylsulfinylquinoxaline starting from 2-sulfanylquinoxaline is also described and in the quinazoline series a synthetic route has been developed to prepare 2-tert-butyl-5-phenylsulfinylquinazoline with satisfactory yield as well as 2-tert-butyl-5-tert-butylsulfinyl-4(3H)-quinazolinone and 2-tert-butyl-8-tert-butylsulfinyl-4(3H)-quinazolinone. 相似文献
90.
Abstract— A thin layer of chlorophyll a (around 2000 Å). a p -type organic semiconductor. was sandwiched between two different metals. aluminum and silver. We used the photovoltaic effect in order to study the efficiency of light conversion by the crystalline and anhydrous forms of Chl a . When the photovoltaic cell is illuminated through the semi-transparent aluminum electrode. an action spectrum similar to the visible absorption spectrum of Chl a is obtained. The anhydrous form. always shows a maximum, in the red, at 672 nm and the crystalline one at 746 nm to 738 nm depending on the amount of water vapor present in the measuring area. The light conversion efficiency has been measured at the maximum absorption in the red for both forms of Chl a . For the anhydrous form, we found values as high as 0.036%, which is very significant even compared to 0.21%, the highest value found for the crystalline form. In both cases. the incident light power was approximately 10 μW on the cell. The light conversion efficiency of both forms of Chl a cells was found to depend on a combine effect of the nature of the gas (O1 . N2 . air. Ar. N2 O. SF 6 , H2 ) and the amount of water vapor present in the measuring area. The best conversion efficiency was obtained with O 2 , or air saturated with water. This combined effect was very large for the crystalline form whereas the anhydrous form was only slightly affected. 相似文献