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971.
王乃兴  陈博仁 《合成化学》1993,1(3):252-254,267
多硝基多氨基三唑类衍生物作为含能材料,具有高氮、致密、钝感等优点。本文通过3-氨基-1,2,4-三唑和三硝基三氯苯的缩合,再经过三唑碳原子上的硝化反应和芳环上的氨化反应,合成并鉴定了标题化合物。  相似文献   
972.
Despite the versatility of amphoteric molecules, stable and easily accessible ones are still limitedly known. As a result, the discovery of new amphoteric reactivity remains highly desirable. Herein we introduce 3-aminooxetanes as a new family of stable and readily available 1,3-amphoteric molecules and systematically demonstrated their amphoteric reactivity toward polarized π-systems in a diverse range of intermolecular [3 + 2] annulations. These reactions not only enrich the reactivity of oxetanes, but also provide convergent access to valuable heterocycles.

Despite the versatility of amphoteric molecules, stable and easily accessible ones are still limitedly known.

Amphoteric molecules, which bear both nucleophilic and electrophilic sites with orthogonal reactivity, represent an attractive platform for the development of chemoselective transformations.1 For example, isocyanides are well-established 1,1-amphoteric molecules, with the terminal carbon being both nucleophilic and electrophilic, and this feature has enabled their exceptional reactivity in numerous multi-component reactions.2 In the past few decades, substantial effort has been devoted to the search for new amphoteric molecules.1–5 Among them, 1,3-amphoteric molecules proved to be versatile. The Yudin and Beauchemin laboratories have independently developed two types of such molecules, α-aziridine aldehydes and amino isocyanates, respectively.4,5 With an electrophilic carbon and a nucleophilic nitrogen in relative 1,3-positions, these molecules are particularly useful for the chemoselective synthesis of heterocycles with high bond-forming efficiency without protective groups (Fig. 1). However, such elegant amphoteric systems still remain scarce. Therefore, the development of new stable amphoteric molecules with easy access remains highly desirable.Open in a separate windowFig. 1Representative [1,3]-amphoteric molecules versus 3-aminooxetanes.In this context, herein we introduce 3-aminooxetanes as a new type of 1,3-amphoteric molecules and systematically demonstrate their reactivity in a range of [3 + 2] annulations, providing rapid access to diverse heterocycles. Notably, 3-aminooxetanes are bench-stable and either commercially available or easily accessible. However, their amphoteric reactivity has not been appreciated previously.Oxetane is a useful functional group in both drug discovery and organic synthesis.6–9 Owing to the ring strain, it is prone to nucleophilic ring-opening, in which it serves as an electrophile (Scheme 1A).6–8 We envisioned that, if a nucleophilic group is installed in the 3-position (e.g., amino group), such molecules should exhibit 1,3-amphoteric reactivity due to the presence of both nucleophilic and electrophilic sites (Scheme 1B). Importantly, the 1,3-relative position is crucial for inhibiting self-destructive intra- or intermolecular ring-opening (i.e. the 3-nucleophilic site attack on oxetane itself) due to high barriers. Thus, such orthogonality is beneficial to their stability. In contrast, the nucleophilic site is expected to react with an external polarized π bond (e.g., X = Y, Scheme 1B), which enables a better-positioned nucleophile (Y) to attack the oxetane and cyclize. Thus, a formal [3 + 2] annulation should be expected. Unlike the well-known SN2 reactivity of oxetanes with simple bond formation, this amphoteric reactivity would greatly enrich the chemistry of oxetanes with multiple bond formations and provide expedient access to various heterocycles. In contrast to the conventional approaches that require presynthesis of advanced intermediates (e.g., intramolecular ring-opening),8 the exploitation of such amphoteric reactivity in an intermolecular convergent manner from simple substrates would be more practically useful. Moreover, more activation modes could be envisioned in addition to oxetane activation. In 2015, Kleij and coworkers reported an example of cyclization between 3-aminooxetane and CO2 in 55% yield, which provided a pioneering precedent.10 However, a systematic study to fully reveal such amphoteric reactivity in a broad context remains unknown in the literature.Open in a separate windowScheme 1Typical oxetane reactivity and the new amphoteric reactivity.To test our hypothesis, we began with the commercially available 3-aminooxetanes 1a and 1b as the model substrates. Phenyl thioisocyanate 2a and CS2 were initially employed as reaction partners, as they both have a polarized C Created by potrace 1.16, written by Peter Selinger 2001-2019 S bond as well as a relatively strong sulfur nucleophilic motif. Moreover, the resulting desired products, iminothiazolidines and mercaptothiazolidines, are both heterocycles with important biological applications (Fig. 2).11 To our delight, simple mixing these two types of reactants in DCM resulted in spontaneous reactions at room temperature without any catalyst. The corresponding [3 + 2] annulation products iminothiazolidine 3a and mercaptothiazolidine 4a were both formed with excellent efficiency (Scheme 2). It is worth mentioning that catalyst-free ring-opening of an oxetane ring is rarely known, particularly for intermolecular reactions.6–9 In this case, the high efficiency is likely attributed to the suitable choice and perfect position of the in situ generated sulfur nucleophile.Open in a separate windowFig. 2Selected bioactive molecules containing iminothiazolidine and mercaptothiazolidine motifs.Open in a separate windowScheme 2Initial results between 3-aminooxetanes and thiocarbonyl compounds.The catalyst-free annulation protocol is general with respect to various 3-aminooxetanes and isothiocyanates. A range of iminothiazolidines and mercaptothiazolidines were synthesized with high efficiency under mild conditions (Scheme 3). Many of them were obtained in quantitative yield. Quaternary carbon centers could also be generated from 3-substituted 3-aminooxetanes (e.g., 3j). The structure of product 3b was unambiguously confirmed by X-ray crystallography.Open in a separate windowScheme 3Formal [3 + 2] annulation with isothiocyanates and CS2. Reaction conditions: 1 (0.3–0.4 mmol), 2 (1.1 equiv.) or CS2 (1.5 equiv.), DCM (2 mL), RT, 3 h for 3 and 36 h for 4. Yields are for the isolated products.With the initial success of thiocarbonyl partners, we next turned our attention to isocyanates, in which the carbonyl group serves as the [3 + 2] annulation motif. Compared with sulfur as the nucleophilic site in the above cases, the oxygen atom is less nucleophilic. As expected, initial tests of the reactivity by mixing 1b and 5a resulted in no desired annulation product 6a in the absence of a catalyst (Table 1, entry 1). Next, Brønsted acids, including TsOH and the super acid HNTf2, were examined as catalysts, but with no success (entries 2 and 3). We then resorted to various Lewis acids, particularly those oxophilic ones, in hope of activating the oxetane unit. Unfortunately, many of them still remained ineffective (e.g., ZnCl2, AuCl, and FeCl3). However, to our delight, further screening of stronger Lewis acids helped identify Sc(OTf)3, Zn(OTf)2, and In(OTf)3 to be effective at room temperature, leading to the desired iminooxazolidine product 6a in good yield (entries 7–9). Its structure was confirmed by X-ray crystallography. Nevertheless, aiming to search for a cheaper catalyst, we continued to optimize this reaction at a higher temperature using previous ineffective catalysts. Indeed, FeCl3 was found to be effective at 80 °C (61% yield, entry 10), while Brønsted acid TsOH remained ineffective at this temperature (entry 11). Notably, decreasing the loading of FeCl3 to 1 mol% led to a higher yield (89% yield, entry 12). However, further decreasing to 0.5 mol% resulted in slightly diminished efficiency (entry 13).Reaction conditions for annulation with isocyanatesa
EntryCatalystYieldb (%)
10
2TsOH·H2O0
3HNTf20
4ZnCl20
5AuCl0
6FeCl30
7Sc(OTf)374
8Zn(OTf)278
9In(OTf)390
10FeCl3c61
11TsOH·H2Oc0
12FeCl3c (1 mol%)89(84)d
13FeCl3c (0.5 mol%)85
Open in a separate windowaReaction scale: 1b (0.1 mmol), 5a (0.1 mmol), catalyst (10 mol%), toluene (1 mL).bYield based on analysis of the 1H NMR spectra of the crude reaction mixture using trichloroethylene as an internal reference. For all the entries, the urea product from simple amine addition to isocyanate 5a accounts for the mass balance.cRun at 80 °C.dIsolated yield.While there are multiple effective catalysts, FeCl3 was selected for the scope study in view of its low price. Various substituted 3-aminooxetanes and isocyanates were subjected to this annulation protocol (Scheme 4). The corresponding iminooxazolidine products were all obtained in good to excellent yields. Isocyanates containing an electron-donating or electron-withdrawing group were both suitable reaction partners. Remarkably, a 1.5 mmol scale reaction of 6a also worked efficiently.Open in a separate windowScheme 4Formal [3 + 2] annulation between 3-aminooxetanes and isocyanates. Reaction scale: 1 (0.3 mmol), 5 (0.3 mmol), FeCl3 (1 mol%), toluene (2 mL).Although (thio)isocyanates and CS2 have been successfully utilized in the formal [3 + 2] annulation with 3-aminooxetanes, these partners are relatively reactive. We were curious about whether the C Created by potrace 1.16, written by Peter Selinger 2001-2019 O bond in relatively inert molecules could react in a similar manner. For example, the C Created by potrace 1.16, written by Peter Selinger 2001-2019 O bond in CO2 is both thermodynamically and kinetically inert relative to typical organic carbonyl groups. However, as a cheap, abundant and green one-carbon source, CO2 has been a subject of persistent investigations owing to its versatility in various transformations leading to valuable materials.12 Specifically, if CO2 could be employed as a partner for the [3 + 2] annulation with 3-aminooxetanes, it would represent an attractive synthesis of oxazolidinones, a well-known heterocycle with applications in both organic synthesis and medicinal chemistry.13 In this context, we next studied the possibility of utilizing CO2 in our annulation.As expected, the reaction between 1b and CO2 at 1 atmospheric pressure did not proceed without a catalyst (Table 2, entry 1). Next, we examined representative Lewis acids, such as Sc(OTf)3, In(OTf)3 and FeCl3. Among them, Sc(OTf)3 exhibited the highest catalytic activity at room temperature (22% yield, entry 2). The reaction efficiency could be improved at 80 °C (65% yield, entry 6), but no further improvement could be made at a higher temperature or with other solvents. Next, we resorted to organic nitrogen bases, as they were known as effective activators of CO2.14 While Et3N and DABCO were completely ineffective for the reaction in MeCN at 80 °C, fortunately, TMG, TBD, and DBU were competent for the desired process (entries 7–11). Among them, DBU exhibited the best performance, leading to the desired product 7a in 89% yield (entry 11). It is worth noting that the polar solvent MeCN was found to be crucial for the base-catalyzed reactivity. Less polar solvents, such as toluene, DCE or THF, completely shut down the reaction. We believe that effective stabilization of certain polar intermediates involved here is critically beneficial to decreasing the reaction barrier. Finally, unlike the previous Lewis acid-catalyzed annulation with isocyanates, this base-catalyzed [3 + 2] annulation with CO2 proceeds via a different activation mode (i.e., to activate CO2 rather than oxetane). We believe that expansion of possible activation modes in this type of amphoteric reactivity will enrich the chemistry of oxetanes.Reaction conditions for annulation with CO2a
EntryCatalyst T Conv. (%)Yield (%)
1RT00
2Sc(OTf)3RT4822
3In(OTf)3RT339
4Zn(OTf)2RT70
5Sc(OTf)360 °C10061
6Sc(OTf)380 °C10065
7Et3N80 °C00
8DABCO80 °C50
9TMG80 °C7254
10TBD80 °C10088
11DBU80 °C10089
Open in a separate windowaReaction scale: 1b (0.1 mmol), CO2 (1 atm), solvent (0.5 mL). Yields based on analysis of the 1H NMR spectra of the crude reaction mixture using CH2Br2 as an internal standard.We next examined the scope of this CO2-fixation process. Unfortunately, at a larger scale (0.5 mmol), the same condition (entry 11, Table 2) could not lead to complete conversion within 12 h. Therefore, further optimization aiming to accelerate the reaction was performed. Indeed, a higher concentration (1.0 M) resulted in a higher rate without affecting the yield. As shown in Scheme 5, a wide variety of 3-aminooxetanes were smoothly converted to the corresponding oxazolidinones in high yields. Both electron-donating and electron-withdrawing substituents on the N-benzyl group did not affect the efficiency. Heterocycle-based N-benzyl or N-allylic substituents are all suitable substrates. However, for regular alkyl substituents, such as homobenzyl (7h) or n-butyl (7j), the stronger base catalyst TBD was needed to achieve good efficiency. Furthermore, this reaction can tolerate steric hindrance in the 3-position of the oxetane (7k), where a quaternary carbon center could be incorporated. However, increasing the size of the N-substituent, such as the secondary alkyl groups in 7i and 7l, did influence the reactivity, thus requiring a higher temperature (100 °C). This process exhibited good compatibility with diverse functional groups, such as ethers, pyridines, aryl halides, olefins, silyl-protected alcohols, and phthalimides. Finally, this protocol is also capable of generating various oxazolidinones embedded in a different structural context, such as chiral oxazaolidinone 7l, bis(oxazolidinone) 7m, and polyheterocycle-fused oxazolidinone 7o.Open in a separate windowScheme 5Formal [3 + 2] annulation between 3-aminooxetanes and CO2. aReaction scale: 1 (0.5 mmol), CO2 (1 atm), DBU (10 mol%), MeCN (0.5 mL). Isolated yield. bRun with TBD as the catalyst. cRun with DMF as solvent at 100 °C.In summary, 3-aminooxetanes have been systematically demonstrated, for the first time, as versatile 1,3-amphoteric molecules. They are a new addition to the limited family of amphoteric molecules. Though previously unappreciated, these molecules exhibited various advantages over the related known 1,3-amphotric molecules (e.g., α-aziridine aldehydes and amino isocyanates), including easy access and extraordinary stability. The perfect position of the nucleophilic nitrogen together with the orthogonal electrophilic carbon allowed them to participate in a diverse range of intermolecular formal [3 + 2] annulations with polarized π-systems, leading to rapid access to various valuable nitrogen heterocycles. Different types of polarized double bonds, from reactive (thio)isocyanates to inert CO2, all participated efficiently in these highly selective annulations with or without a suitable catalyst. Furthermore, the involvement of more functional groups in such amphoteric reactivity allowed manifold activation modes, thereby greatly enriching the reactivity of the already versatile oxetane unit to a new dimension. These reactions, proceeding in an intermolecular convergent manner from readily available substrates, provide expedient access to various valuable nitrogen heterocycles, thus being complementary to those traditional methods that either required multiple steps or less available substrates. More studies on the 1,3-amphoteric reactivity of 3-oxetanes, particularly those with other partners as well as their asymmetric variants, are ongoing in our laboratory.  相似文献   
973.
Summary Classes of coronoids (or degenerate coronoids), r and q are obtained by providing the rectangle-shaped benzenoids Rj (m, 3) with a naphthalenic or pyrenic hole, respectively. The numbers of Kekulé structures (K) are studied. It was found for theK numbers of the classes in question:r=4/5R andq=1/5R. The classes r and q are similar to r and q, respectively, but the naphthalenic or pyrenic hole is oriented in a different way. For these classes it was found:r=3/5R,q=2/5R.
Die Anzahl von Kekulé-Strukturen für hochkondensierte Benzenoide mit rechteckigem Umriß, 8. Mitt.: Einige perforierte benzenoide Rechteck-Strukturen
Zusammenfassung Es werden Klassen r und q von Coronoiden (oder degenerierten Coronoiden) erhalten, wobei Benzenoide mit rechteckigem Umriß, Rj(m, 3), mit einem Naphthalin- oder Pyren-Loch versehen werden. Die Anzahl von Kekulé-Strukturen (K) wird untersucht; dabei wurde für die untersuchten Klassenr=4/5R undq=1/5R gefunden. Die Klassen r und q verhalten sich ähnlich, das Naphthalin- oder Pyren-Loch ist jedoch anders orientiert; dafür wurder=3/5R undq=2/5R gefunden.
  相似文献   
974.
Eight novel compounds were synthesized by a facile and mild method with high yields, and the structures of all the compounds were characterized by 1H NMR IR mass and high resolution mass spectroscopy. Their inhibitory activity against insect-flight and trehalase in vitro were screened. Some target compounds have moderate inhibitory activity against trehalase, and show inhibition action to insect-flight.  相似文献   
975.
[reaction: see text] A mild and transition-metal-free method for the alpha-arylation of aliphatic nitriles with activated heteroaryl halides was developed using NaHMDS or KHMDS as base at ambient temperature. The key to the success of this method is generation of the nitrile anion in the presence of the heteroaryl halide. The method is applicable to both primary and secondary carbonitriles and a wide range of heteroaryl halides. Selective monoarylation was observed with primary carbonitriles. The operational simplicity and the mild reaction conditions add to the value of this method as a practical alternative to the preparation of alpha-heteroaryl carbonitriles.  相似文献   
976.
trans-RhCl(CO)(TPPTS)2 (TPPTS=tris(m-sulfonatophenyl)phosphine) has been intercalated into Zn-Al layered double hydroxides (LDHs) by the method of ion exchange. The structure, composition and thermal stability of the composite material have been characterized by powder X-ray diffraction, Fourier transform infrared and 31P solid-state magic-angle spinning nuclear magnetic resonance spectroscopy, elemental analysis, thermogravimetry, and differential thermal analysis. The geometry of trans-RhCl(CO)(TPPTS)2 was fully optimized using the PM3 semiempirical molecular orbital method, and a schematic model for the intercalated species has been proposed. The thermal stability of trans-RhCl(CO)(TPPTS)2 is significantly enhanced by intercalation, which suggests that such materials may have prospective application as the basis of a supported catalyst system for the hydroformylation of higher olefins.  相似文献   
977.
ZrO2在Cu-ZnO-ZrO2甲醇水蒸汽重整制氢催化剂中的作用   总被引:2,自引:0,他引:2  
通过对一系列Cu-ZnO-ZrO2甲醇水蒸汽重整(SRM)催化剂的XRD、TEM和BET表征及催化性能测定,研究催化剂中ZrO2对催化剂粒径、比表面以及对SRM反应性能的影响.结果表明,ZrO2的加入,使催化剂的粒径从15 nm降至10 nm(其中CuO和ZnO的平均粒径分别从7.7和10.4 nm降至3.9和8.7 nm),BET比表面从60 m2•g-1增至78 m2•g-1.随着催化剂含ZrO2量不同,甲醇的转化率和H2、CO2的选择性均产生变化,当催化剂中Zr含量为24.0%(w),反应温度为220 ℃,水、醇摩尔比为1.3时,甲醇的转化率达到51.6%, H2和CO2的选择性达到100%(CO和CH4在产物气体中的体积分数小于10-4),这一结果对甲醇燃料电池甲醇重整器的应用具有重要的意义.  相似文献   
978.
Treatment of 5-trimethylsilylthebaine with L-Selectride gave rise to a rearrangement to 10-trimethylsilylbractazonine through migration of the phenyl group, whereas treatment of thebaine with strong Lewis acids is known to lead to a similar rearrangement through migration of the alkyl bridge to give, after reduction, (+)-neodihydrothebaine. It is suggested that the rearrangement of the alkyl group of thebaine is favored due to the formation of a tertiary benzylic cation. However, for 5-trimethylsilylthebaine, the lithium ion of L-Selectride acts as the Lewis acid and the beta-silyl effect dominates in the stabilization of any positive charge. This rearrangement provides a clear example of the greater relative migratory aptitude of phenyl groups over alkyl groups, and provides an efficient synthesis of (+)-bractazonine from thebaine.  相似文献   
979.
The structure and anodic performance of boron-doped and undoped mesocarbon microbeads (MCMBs) have been comparatively studied and the results obtained by XPS, XRD, SEM, Raman spectroscopy and electrochemical measurements are discussed. It is found that boron doping introduces a depressed d 002 spacing and the larger amount of "unorganized carbon", which induces vacancy formation in the graphite planes and leads to a quite different morphology from that of the undoped material. Electrochemical charge/discharge cycle tests indicated that after boron doping the lithium intercalation was carried through at a somewhat higher potential, being attended by greater irreversible capacity loss. Electronic Publication  相似文献   
980.
含环氧端基酚酞聚芳醚酮E-PEK的合成及表征   总被引:3,自引:1,他引:3  
由酚酞和4,4′-二氯二苯酮经亲核缩聚制得了一系列不同分子量的含—OK端基的聚醚酮低聚物,将其与环氧氯丙烷反应得到了分子量为1000~8000的含环氧端基聚芳醚酮(E-PEK)。用IR和~1H NMR表征了E-PEK的分子链结构,测定了T_g、溶解性和熔融粘度。研究了E-PEK/DDE体系的固化,固化后树脂的T_(g∞)=183~215℃,与低聚物的初始分子量有关。  相似文献   
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