Advanced diagnostic plan applied to the Royal Villa in Naples

Abstract

To achieve adequate restoration project, the moment of choice of the type of intervention is a very delicate phase that necessarily involves a thorough understanding of the asset in all its aspects, as the location, the history, the architecture, the state of preservation, the pathologies causing the degradation, the degradation in itself, the analysis of constituent materials. The set of all that can be investigated on a product (cultural), to obtaining important information for subsequent maintenance, conservation and/or restoration actions, is what is called a diagnostic plan. In this case it was applied directly on a monument of national importance: the Royal Villa in Naples (today the Municipal Villa). The analysis were performed in situ and in the laboratory (SEM-EDS) on samples taken directly at the Villa, which allowed the creation of a series of analytical cards, containing digital data, required for the selection of expense future of intervention.     

Effects of Citicoline,Homotaurine, and Vitamin E on Contrast Sensitivity and Visual-Related Quality of Life in Patients with Primary Open-Angle Glaucoma: A Preliminary Study

The aim of the present study was to evaluate the effects of supplementation with a fixed combination of citicoline 500 mg, homotaurine 50 mg, and vitamin E 12 mg (CIT/HOMO/VITE) on contrast sensitivity and visual-related quality of life in patients with primary open-angle glaucoma (POAG) in mild stage. This was a multicenter, observational, cross-over, short-term, pilot study on POAG patients with stable controlled intraocular pressure (IOP). Patients were randomly assigned to Group 1 (current topical therapy for 4 months and then current topical therapy plus CIT/HOMO/VITE for 4 months) or Group 2 (CIT/HOMO/VITE in addition to current topical therapy for 4 months and then topical therapy alone for 4 months). Best-corrected visual acuity, IOP, visual field, and the Spaeth/Richman contrast sensitivity (SPARCS) test score were recorded at baseline and after 4 and 8 months. The Glaucoma Quality of Life-15 (GQL-15) questionnaire was administered at each check time. Forty-four patients were assigned to Group 1 and 65 to Group 2. Over the follow-up period, there were no significant changes in IOP or visual field findings, whereas SPARCS and GQL-15 findings significantly varied from baseline, both being improved in subjects treated with CIT/HOMO/VITE fixed combination. These results demonstrate that a daily intake of a fixed combination of citicoline, homotaurine, and vitamin E in addition to the topical medical treatment significantly increased the total score of the contrast sensitivity test and the quality of life in patients with POAG.     

Rami globali e parametrizzazione

Summary In this paper, using the theory of henselian rings and in particular the notion of henselian and strict henselian couples, we study the behaviour of analytic branches of an affine algebraic variety at a point x, when x varies along a singular subvariety; moreover we construct an algebraic and canonical procedure, which parametrises the branches.

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Lavoro eseguito nell'ambito della sez. 3 del G.N.S.A.G.A. del C.N.R. e con il supporto finanziario del Ministero della Pubblica Istruzione.     

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives

Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors.     

REDUCIBILITY IN SOME CATEGORIES OF PARTIAL RECURSIVE OPERATORS

We consider two categories with one object, namely the set of all partial functions of one variable from the set of natural numbers into itself; the morphisms are the partial recursive operators in one case, and certain continuous partial mappings in the other case. We show that these categories are recursion categories and we characterize the domains and the complete domains. Some observations are made on a notion of reducibility obtained by using the total morphisms of these categories, and, subsequently, the general recursive operators.     

Approximation and regular perturbation of optimal control problems via Hamilton-Jacobi theory

We present two convergence theorems for Hamilton-Jacobi equations and we apply them to the convergence of approximations and perturbations of optimal control problems and of two-players zero-sum differential games. One of our results is, for instance, the following. LetT andT _h be the minimal time functions to reach the origin of two control systemsy = f(y, a) andy = f _h (y, a), both locally controllable in the origin, and letK be any compact set of points controllable to the origin. If f _h –f Ch, then |T(x) – T _h (x)| C _K h , for all x K, where is the exponent of Hölder continuity ofT(x).     

An analysis of the interaction energy in some SN2 reactions

The interaction energy between an incoming group X^– and the substrate CRH₂Y at the geometry of the transition state (TS) for bimolecular nucleophilic substitution reactions (with X, Y, and R equal to H and F) has been subjected to decomposition according to the Morokuma scheme. The influence of the basis set and of the geometry chosen for the TS is examined. The results bring out regular trends in the different terms of the decomposition along the whole set of reactions, but they are not sufficient to give a rationale of the energetic factors involved in these reactions.     

A Modular Approach for Interlocking Enzymes in Whatman Paper

A potentially universal approach is presented for enzyme attachment to cellulose that significantly enhances enzyme stability while retaining high activity, and involves no chemical functionalization of cellulose. Bovine serum albumin (BSA) was interlocked in cellulose to form a protein‐friendly surface (named BSA‐Paper), while also providing COOH and NH₂ groups for subsequent attachment of enzymes. The desired enzyme is then mixed with additional BSA and interlocked on BSA‐Paper. The second BSA layer dilutes and crosslinks the enzyme for improved stability. Laccase was tested as a model enzyme for interlocking on BSA‐Paper, and was found to retain over 100 % activity and was 240 times more stable at 25 °C (half life=180 d) than laccase. This new approach was also tested with a few other enzymes with encouraging results, thus providing a potentially universal method for stabilization of enzymes on cellulose with retention of high activities.     

The protonation of three-membered ring molecules Theab initio SCF versus the electrostatic picture of the proton approach

The protonation processes for eight three-membered ring molecules have been investigated using the SCF LCAO MO method with Gaussian basis sets and the results are compared with those obtained at the first order approximation, i.e. the electrostatic approximation. The electrostatic results are linearly connected with the SCF ones and are sufficient to get an ordering of the protonation energies in different chemical sites and to obtain reliable representations of the proton approaching paths.