全文获取类型
收费全文 | 510篇 |
免费 | 26篇 |
专业分类
化学 | 330篇 |
晶体学 | 2篇 |
力学 | 9篇 |
数学 | 60篇 |
物理学 | 135篇 |
出版年
2023年 | 1篇 |
2022年 | 21篇 |
2021年 | 18篇 |
2020年 | 16篇 |
2019年 | 21篇 |
2018年 | 15篇 |
2017年 | 11篇 |
2016年 | 28篇 |
2015年 | 18篇 |
2014年 | 23篇 |
2013年 | 34篇 |
2012年 | 45篇 |
2011年 | 37篇 |
2010年 | 28篇 |
2009年 | 27篇 |
2008年 | 36篇 |
2007年 | 17篇 |
2006年 | 28篇 |
2005年 | 12篇 |
2004年 | 16篇 |
2003年 | 7篇 |
2002年 | 8篇 |
2001年 | 6篇 |
2000年 | 6篇 |
1999年 | 7篇 |
1998年 | 6篇 |
1997年 | 10篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 7篇 |
1992年 | 1篇 |
1991年 | 7篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 3篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1977年 | 1篇 |
1975年 | 2篇 |
1973年 | 1篇 |
排序方式: 共有536条查询结果,搜索用时 15 毫秒
11.
12.
Cardoso Daisy Alves Valle Eliana Maíra Agostini Codognoto Lucia 《Journal of Solid State Electrochemistry》2018,22(5):1549-1555
Journal of Solid State Electrochemistry - In this work, the interaction of the pesticide methyl parathion (MP) with the lead metal ion was evaluated using a carbon electrode reused from a zinc... 相似文献
13.
J. L. Cardoso 《Analysis Mathematica》2016,42(4):323-337
The Hahn–Exton (third Jackson) q-Bessel function attracts the attention of many researchers in mathematics. We add a few more properties of this important function, such as some identities and upper bounds involving this function, in relation with the coefficients of the corresponding basic Fourier–Bessel expansions. 相似文献
14.
15.
16.
Immobilized purine nucleoside phosphorylase from Schistosoma mansoni for specific inhibition studies
Marcela Cristina de Moraes Carmen L. Cardoso Quezia B. Cass 《Analytical and bioanalytical chemistry》2013,405(14):4871-4878
The parasite Schistosoma mansoni (Sm) depends exclusively on the salvage pathway for its purine requirements. The enzyme purine nucleoside phosphorylase (PNP) is, therefore, a promising target for development of antischistosomal agents and an assay for screening of inhibitors. To enable this, immobilized SmPNP reactors were produced. By quantification of hypoxanthine by liquid chromatography, kinetic constants (K M) for the substrate inosine were determined for the free and immobilized enzyme as 110 ± 6.90 μmol?L ?1 and 164 ± 13.4 μmol?L ?1 , respectively, indicating that immobilization did not affect enzyme activity. Furthermore, the enzyme retained 25 % of its activity after four months. Non-Michaelis kinetics for the phosphate substrate, and capacity for Pi-independent hydrolysis were also demonstrated, despite the low rate of enzymatic catalysis. Use of an SmPNP immobilized enzyme reactor (IMER) for inhibitor-screening assays was demonstrated with a small library of 9-deazaguanine analogues. The method had high selectivity and specificity compared with screening by use of the free enzyme by the Kalckar method, and furnished results without the need for verification of the absence of false positives. Figure
A cartoon illustrating the online SmPNP-IMER activity assay 相似文献
17.
André Luís Branco de Barros Saulo Fernandes de Andrade José Dias de Souza Filho Valbert Nascimento Cardoso Ricardo José Alves 《Journal of Radioanalytical and Nuclear Chemistry》2013,298(1):605-609
Glycodendrimers are neoglycoconjugates that can be considered as bioisosters of glycoproteins, since they can mimic the multivalent interactions of lectin-carbohydrate. The ability of glycodendrimers to present multivalent interactions with lectins as compared to a monovalent ligand is referred to as “cluster effect”. It is expected that, because of the cluster effect, glycodendrimers would result in a better association with lectins than mono-carbohydrate anchored systems. Radioisotopes are useful to evaluate biodistribution of molecules. This study is important to obtain information about molecule–receptor interactions. Indeed, such study can provide an exquisite tool to evaluate the affinity of certain molecules to specific areas in the body, leading to the development of new radiopharmaceuticals and/or drug delivery systems. Herein, we describe a d-galactose coated low molecular weight PAMAM G0 dendrimer that was successfully radiolabeled with technetium-99m. Biodistribution studies and scintigraphic images were performed in healthy mice. It was observed high liver uptake which was significantly reduced in blocking studies, indicating hepatic specificity. Therefore, low molecular weight glycodendrimer can be considered as useful platform for selective targeting of drugs to the liver and to assess hepatic function. 相似文献
18.
Machado Poliana A. L. Cavalcanti Marcello H. S. Silva Fábio A. B. de Almeida Eduardo T. Cardoso Marcus V. C. Mesquita Anderson F. Lemes Nelson H. T. Virtuoso Luciano S. 《Journal of solution chemistry》2022,51(3):320-344
Journal of Solution Chemistry - Liquid–liquid equilibrium (LLE) data and phase diagrams for new aqueous two-phase systems (ATPSs) containing 1-butyl-3-methylimidazolium chloride... 相似文献
19.
20.
Lara R. S. Fonseca Gonalo R. Silva ngelo Luís Henrique J. Cardoso Sara Correia Ctia V. Vaz Ana P. Duarte Sílvia Socorro 《Molecules (Basel, Switzerland)》2021,26(10)
Sweet cherries (Prunus avium L.) are among the most appreciated fruits worldwide because of their organoleptic properties and nutritional value. The accurate phytochemical composition and nutritional value of sweet cherries depends on the climatic region, cultivar, and bioaccessibility and bioavailability of specific compounds. Nevertheless, sweet cherry extracts are highly enriched in several phenolic compounds with relevant bioactivity. Over the years, technological advances in chemical analysis and fields as varied as proteomics, genomics and bioinformatics, have allowed the detailed characterization of the sweet cherry bioactive phytonutrients and their biological function. In this context, the effect of sweet cherries on suppressing important events in the carcinogenic process, such as oxidative stress and inflammation, was widely documented. Interestingly, results from our research group and others have widened the action of sweet cherries to many hallmarks of cancer, namely metabolic reprogramming. The present review discusses the anticarcinogenic potential of sweet cherries by addressing their phytochemical composition, the bioaccessibility and bioavailability of specific bioactive compounds, and the existing knowledge concerning the effects against oxidative stress, chronic inflammation, deregulated cell proliferation and apoptosis, invasion and metastization, and metabolic alterations. Globally, this review highlights the prospective use of sweet cherries as a dietary supplement or in cancer treatment. 相似文献