有机分子与聚电解质静电吸附成膜特性研究

选取多种有机分子及聚电解质，采用静电吸附自组装法制备了聚电解质，聚电解质、聚电解质，有机分子、有机分子，有机分子的复合薄膜，讨论了这些体系的静电吸附成膜特性及其成膜机理．     

奥利司他的全合成研究进展

综述了减肥药物奥利司他的全合成的研究进展. 根据合成策略上的不同, 将全合成研究分三部分进行了概述.     

TiO_2-CeO_2催化剂湿式氧化苯酚的活性研究

采用共沉淀法制备了湿式氧化降解苯酚的TiO2-CeO2催化剂,测定了反应过程中不同反应时间的COD去除率,结果表明,当Ti、Ce摩尔比为3∶1时,在150℃、总压5MPa(其中氧分压4.5MPa)时,所制备的催化剂活性最高,反应90分钟COD去除率可以达到71%.对催化剂进行了比表面积、XRD和XPS测试,结果表明,高效的催化剂具有较多的活性位、催化剂粉末体系Ce的变价特性以及大量的表面吸附氧.     

硝基苯在离子液体BMimBF4-H2O中的电还原

采用循环伏安法和恒电位电解法研究了离子液体BMimBF4-H2O 中硝基苯在微铂电极上的电还原特性. 实验表明, 在BMimBF4中, 随着硝基苯和水的浓度变化, 循环伏安曲线的峰电位和峰电流呈现复杂的变化规律; 硝基苯在铂电极上的电还原反应为双分子8 电子3 步骤电化学过程, 第一步反应为准可逆单分子单电子转移步骤, 产生阴离子自由基, 第二步为2 电子转移步骤, 并伴有随后的双分子不可逆自由基偶合化学反应, 主要产物为氧化偶氮苯, 第三步是2 电子转移产生偶氮苯的过程.     

The application of diethylaminosulfur trifluoride in the synthesis of fluorinated sterols and bile acids

Methyl 3,3-(ethylenedioxy)-6β-fluoro-5β-cholan-24-oate has been prepared starting from hyodeoxycholic acid and 3,3-(ethylenedioxy)-7( and β)-fluorocholestan-22-al starting from stigmasterol, using diethylaminosulfur trifluoride as the fluorinating agent. These molecules will be used to synthesize analogs of the aminosterol antibiotic squalamine.     

ELECTRON PARAMAGNETIC RESONANCE STUDIES OF SINGLE CRYSTAL SODIUM HEXAMOLYBDOCHROMATE (Ⅲ)Cr~(3+)/Na_3(AlMo_6O_(24)H_6)·8H_2O

An X-band EPR study on a Na_3(CrMo_6O_(24)H_6)·8H_2O single crystal diluted by its isomor-phic compound Na_3(AlMo_6O_(24)H_6)·8H_2O at room temperature is reported. Using the least squares-fitting method to simulate the EPR data for principal planes, the Hamiltonian parameterswere obtained. The principal values of the g tensors are g_(ZZ) = 1.904, g_(XX)= 1.973, g_(YY)=1.933. The zero field splitting tensor parameters are D = 0.275 cm~(-1), E = 0.05 cm~(-1). The fielddependence of Cr~(3+) energy levels with field at different angles from the principal axes whenthe field is along the principal planes is calculated based on these experimental parameters.The isofrequency plots of calculated field vs. angle are also shown. They agree well with theexperimental results.     

十二烷基硫酸钠毛细管电泳法分析非还原单克隆抗体药物纯度的前处理条件优化

十二烷基硫酸钠毛细管电泳法因具有快速、分辨率高的优势，已成为单克隆抗体纯度分析的主流方法。在非还原单克隆抗体纯度检测中，其样品前处理过程对于结果有显著影响。为优化样品前处理，考察了以碘乙酰胺和N-乙基马来酰亚胺为巯基封闭剂，在pH 6.0~9.0的样品缓冲液条件下，不同种类和批次的单抗的纯度。发现在两种巯基封闭剂中，高pH的样品缓冲液会影响巯基封闭的效果，产生较多的抗体片段；而在低pH条件下，抗体片段较少，单抗的纯度更高。因此在进行非还原单抗的纯度检测中，pH 6.0的样品缓冲液为最佳的前处理条件。     

Effect of photothermal therapy on breast tumor vascular contents: noninvasive monitoring by near-infrared spectroscopy

The goal of this study was to investigate the effect of photothermal laser irradiation on rat breast tumor (DMBA-4) vascular contents. An 805-nm diode laser was used in our experiment with a power density ranging from 0.32 to 1.27 W/cm2. The dynamic changes of oxygenated hemoglobin and total hemoglobin concentrations, delta[HbO2] and delta[Hb]total, in rat tumors during photothermal irradiation were noninvasively monitored by a near-infrared spectroscopy system. A multichannel thermal detection system was also used simultaneously to record temperatures at different locations within the tumors. Our experimental results showed that: (1) photoirradiation did have the ability to induce hyperthermic effects inside the rat breast tumors in a single exponential trend; (2) the significant changes (P < 0.005) of delta[HbO2] and delta[Hb]total in response to a low dosage of laser irradiation (0.32 W/cm2) have a single exponential increasing trend, similar to that seen in the tumor interior temperature; and (3) the increase in magnitude of delta[HbO2] is nearly two times greater than that of delta[Hb]total, suggesting that photoirradiation may enhance tumor vascular oxygenation. The last observation may be important to reveal the hidden mechanism of photoirradiation on tumors, leading to improvement of tumor treatment efficiency.     

ZSM-5/Y复合分子筛在烃类催化裂化催化剂中的应用研究

以大庆减压蜡油为原料，考察了水热脱铝ZSM-5/Y复合分子筛的催化裂化性能，并与经同样条件水热脱铝的ZSM-5和Y型沸石的机械混合分子筛进行了对比研究。结果表明，与机械混合样品相比，复合分子筛具有较大的柴油产率和气体产率，汽油产率降低。从复合分子筛结构和ZSM-5的择形催化两方面分析了复合分子筛和机械混合分子筛裂化性能差别的原因。复合分子筛的聚集体结构不利于大分子进入分子筛结构中进行裂化，有利于汽油组分的裂化。气体数据分析支持了复合分子筛的结构特点。     

Two Novel Sub-skeleton Types of ent-Kauranoids from Isodon gesneroides

Two novel ent-kauranoids with new sub-skeleton types, gesneroidins G and H were isolated as white powder from the ether extract of the leaves of Isodon gesneroides through normal phase column chromatography. Their structures were elucidated as 3β,6α,7β-triacetoxyl-15-hydroxyl-14-oxo-ent- 15,16-seco-kaur-11,17-olide and Iα-hydroxyl-3β,6α,7β,11 β-tetraacetoxyl-ent-nor-15,17-kaur-8,16-olide on the basis of the spectral evidences including ID and 2D NMR spectra.