Model Systems for Evidencing the Mediator Role of Riboflavin in the UVA Cross-Linking Treatment of Keratoconus

Riboflavin under UVA radiation generates reactive oxygen species (ROS) that can induce various changes in biological systems. Under controlled conditions, these processes can be used in some treatments for ocular or dermal diseases. For instance, corneal cross-linking (CXL) treatment of keratoconus involves UVA irradiation combined with riboflavin aiming to induce the formation of new collagen fibrils in cornea. To reduce the damaging effect of ROS formed in the presence of riboflavin and UVA, the CXL treatment is performed with the addition of polysaccharides (dextran). Hyaluronic acid is a polysaccharide that can be found in the aqueous layer of the tear film. In many cases, keratoconus patients also present dry eye syndrome that can be reduced by the application of topical solutions containing hyaluronic acid. This study presents physico-chemical evidence on the effect of riboflavin on collagen fibril formation revealed by the following methods: differential scanning microcalorimetry, rheology, and STEM images. The collagen used was extracted from calf skin that contains type I collagen similar to that found in the eye. Spin trapping experiments on collagen/hyaluronic acid/riboflavin solutions evidenced the formation of ROS species by electron paramagnetic resonance measurements.     

On a Theorem of Deutsch and Singer

We introduce the notion of a starshaped set-valued function, and relate it to convex set-valued functions. We prove a theorem which, in the convex case, implies that single-valuedness is exceptional if the function is not everywhere single-valued. A second result shows a remarkable costantness of images for starshaped set-valued functions. Both theorems were inspired from a result of Deutsch and Singer, which they strengthen.     

相对论性核与乳胶(Ag)碰撞中灰粒子的系统研究 *

用描写相对论性核 核碰撞的LUCIAE模型和相应的事件产生器系统地研究了 1 4.6 ,6 0和 2 0 0AGeV的O核、2 0 0AGeV的Si和S核以及 1 1 .6AGeV的Au核与乳胶 (Ag)碰撞中灰粒子产生的平均多重数、多重数分布以及角分布 3个物理量同入射能量、射弹质量及碰撞中心度间的关系 ,还研究了再散射在灰粒子产生机制中的作用 .LUCIAE的这些研究结果与相应的EMU0 1乳胶实验结果都相一致 .     

算术级数中的陈景润定理 *

设N为一充分大的偶数且q≥ 1 ,(l_i,q) =1 (i=1 ,2 ) ,l₁+l₂ ≡N(modq) .证明了方程N =p+P₂ ,p≡l1(modq) ,P₂ ≡l₂ (modq)对区间 1 ,N^1/37中除了ON^1/37log^-5 N个例外的整数q ,都有无穷多解 ,其中p是素数 ,P₂ 为一至多有2个素因子的殆素数 .     

Viewing and realizing diameters

This paper is about diameters of compact sets. These are chords of maximal length. On one hand we see that the sum of the angles under which we see a diameter from two points of the set separated by the diameter is never smaller than 5π/6. On the other hand we describe cases in which the diameter of a point-symmetric set must join symmetric points.      

涡旋成对分布和对二元速度关联函数的影响

本文考虑了涡旋之间相互作用的影响,假定均匀各向同性湍流场是由涡旋对在整个空间等几率分布而成,这样计算出的二元速度关联函数f(γ/λ)在远处略有提高,这个结果是与Bennett和Corrsin的实验结果和其他实验结果相合的。     

Investigation of advanced strain-path dependent material models for sheet metal forming simulations

Sheet metal forming processes often involve complex loading sequences. To improve the prediction of some undesirable phenomena, such as springback, physical behavior models should be considered. This paper investigates springback behavior predicted by advanced elastoplastic hardening models which combine isotropic and kinematic hardening and take strain-path changes into account. A dislocation-based microstructural hardening model formulated from physical observations and the more classical cyclic model of Chaboche have been considered in this work. Numerical implementation was carried out in the ABAQUS software using a return mapping algorithm with a combined backward Euler and semi-analytical integration scheme of the constitutive equations. The capability of each model to reproduce transient hardening phenomena at abrupt strain-path changes has been shown via simulations of sequential rheological tests. A springback analysis of strip drawing tests was performed in order to emphasize the impact of several influential parameters, namely: process, numerical and behavior parameters. The effect of the two hardening models with respect to the process parameters has been specifically highlighted.     

Pseudogap in doped Mott insulators is the near-neighbor analogue of the Mott gap

We show that the strong-coupling physics inherent to the insulating Mott state in 2D leads to a jump in the chemical potential upon doping and the emergence of a pseudogap in the single-particle spectrum below a characteristic temperature. The pseudogap arises because any singly occupied site not immediately neighboring a hole experiences a maximum energy barrier for transport equal to t(2)/U, t the nearest-neighbor hopping integral and U the on-site repulsion. The resultant pseudogap cannot vanish before each lattice site, on average, has at least one hole as a near neighbor. The ubiquity of this effect in all doped Mott insulators suggests that the pseudogap in the cuprates has a simple origin.     

Asymptotic and Lyapunov stability of constrained and Poisson equilibria

This paper includes results centered around three topics, all of them related with the nonlinear stability of equilibria in constrained dynamical systems. First, we prove an energy-Casimir type sufficient condition for stability that uses functions that are not necessarily conserved by the flow and that takes into account the asymptotically stable behavior that may occur in certain constrained systems, such as Poisson and Leibniz dynamical systems. Second, this method is specifically adapted to Poisson systems obtained via a reduction procedure and we show in examples that the kind of stability that we propose is appropriate when dealing with the stability of the equilibria of some constrained mechanical systems. Finally, we discuss two situations in which the use of continuous Casimir functions in stability studies is equivalent to the topological stability methods introduced by Patrick et al. (Arch. Rational Mech. Anal., 2004, preprint arXiv:math.DS/0201239v1, to appear).