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31.
32.
Neshev DN Sukhorukov AA Dreischuh A Fischer R Ha S Bolger J Bui L Krolikowski W Eggleton BJ Mitchell A Austin MW Kivshar YS 《Physical review letters》2007,99(12):123901
We present the first observation of spatiospectral control and localization of supercontinuum light through the nonlinear interaction of spectral components in extended periodic structures. We use an array of optical waveguides in a LiNbO3 crystal and employ the interplay between diffraction and nonlinearity to dynamically control the output spectrum of the supercontinuum radiation. This effect presents an efficient scheme for optically tunable spectral filtering of supercontinua. 相似文献
33.
Thuan Nguyen Ngoc Ngan Nguyen Thi Kuo Ping-Chung Trinh Nguyen Thi Nu Thien Le Trung Mai Dam Sao Tuan Nguyen Ngoc Tan Le Van Thang Tran Dinh 《Chemistry of Natural Compounds》2021,57(6):1104-1106
Chemistry of Natural Compounds - 相似文献
34.
Avik Khan Khanh Dang Vu Gregory Chauve Jean Bouchard Bernard Riedl Monique Lacroix 《Cellulose (London, England)》2014,21(5):3457-3468
Microfluidization, which is a high-pressure homogenization technique, was used to develop highly dispersed cellulose nanocrystal (CNC) reinforced chitosan based nanocomposite films. A three factor central composite design with five levels was designed to systematically optimize the microfluidization process. The three factors were the CNC content, the microfluidization pressure and the number of microfluidization cycles. Response surface methodology was used to obtain relationship between the mechanical properties of the nanocomposite films and the factors. Polynomial equations were generated based on the regression analysis of the factors and the predicted properties of the nanocomposite films were in good agreement with the experimental results. Microfluidization effectively reduced the CNC–chitosan aggregates and improved the mechanical properties of the nanocomposite films. Microscopic analysis of the microfluidized nanocomposite films revealed a 10–15 times reduction in the size of the aggregates compared to the non-microfluidized CNC/chitosan films and an increase in the root mean square surface roughness (Rq). 相似文献
35.
Huynh Phuong Truc Tran Trinh Pham Ngoc Dinh Binh Thanh Nguyen Linh Thi Truc Truong Loan Thi Hong Tran Anh Tuan Ho Dung Manh Van Nguyen Dong 《Journal of Radioanalytical and Nuclear Chemistry》2020,324(2):663-671
Journal of Radioanalytical and Nuclear Chemistry - The aim of this study was to find trace elements that increase risk of breast cancer based on the deviation of the concentration of trace elements... 相似文献
36.
Son Tung Ngo Trung Hai Nguyen Nguyen Thanh Tung Pham Cam Nam Khanh B. Vu Van V. Vu 《Journal of computational chemistry》2020,41(7):611-618
Determination of the ligand-binding affinity is an extremely interesting problem. Normally, the free energy perturbation (FEP) method provides an appropriate result. However, it is of great interest to improve the accuracy and precision of this method. In this context, temperature replica exchange molecular dynamics implementation of the FEP computational approach, which we call replica exchange free energy perturbation (REP) was proposed. In particular, during REP simulations, the system can easily escape from being trapped in local minima by exchanging configurations with high temperatures, resulting in significant improvement in the accuracy and precision of protein–ligand binding affinity calculations. The distribution of the decoupling free energy was enlarged, and its mean values were decreased. This results in changes in the magnitude of the calculated binding free energies as well as in alteration in the binding mechanism. Moreover, the REP correlation coefficient with respect to experiment ( RREP = 0.85 ± 0.15 ) is significantly boosted in comparison with the FEP one ( RFEP = 0.64 ± 0.30 ). Furthermore, the root-mean-square error (RMSE) of REP is also smaller than FEP, RMSEREP = 4.28 ± 0.69 versus RMSEFEP = 5.80 ± 1.11 kcal/mol, respectively. © 2019 Wiley Periodicals, Inc. 相似文献
37.
Duong Quoc Hoan Le Thi Hoa Trinh Thi Huan Nguyen Huu Dinh 《Journal of heterocyclic chemistry》2020,57(4):1720-1728
An efficient and simple method has been reported for the synthesis of 4-(1-Chloro-1-nitroethyl)-6,7-dimethoxy-2-methylquinazoline ( 2 ) as a key compound for further transformation to other novel 6,7-dimethoxy-2-methyl-4-substituted quinazolines. The structure of the synthesized compounds was characterized by spectroscopic methods. The pathway of some unprecedented reactions was proposed. (E)-1-(6,7-dimethoxy-2-methylquinazolin-4-yl)-3-(4-nitrophenyl)prop-2-en-1-one (11) exhibits high in vitro cytotoxicity on three cell lines, Hepatocellular carcinoma (Hep-G2), Human lung carcinoma (LU-1), and Human breast carcinoma (MCF-7) with IC50 of 2.1, 11.6 and 2.2 μM, respectively. 相似文献
38.
Paulina X. Medina Rangel Elena Moroni Franck Merlier Prof. Levi A. Gheber Prof. Razi Vago Dr. Bernadette Tse Sum Bui Prof. Karsten Haupt 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(7):2838-2844
One of the most promising strategies to treat cancer is the use of therapeutic antibodies that disrupt cell–cell adhesion mediated by dysregulated cadherins. The principal site where cell–cell adhesion occurs encompasses Trp2 found at the N-terminal region of the protein. Herein, we employed the naturally exposed highly conserved peptide Asp1-Trp2-Val3-Ile4-Pro5-Pro6-Ile7, as epitope to prepare molecularly imprinted polymer nanoparticles (MIP-NPs) to recognize cadherins. Since MIP-NPs target the site responsible for adhesion, they were more potent than commercially available therapeutic antibodies for inhibiting cell–cell adhesion in cell aggregation assays, and for completely disrupting three-dimensional tumor spheroids as well as inhibiting invasion of HeLa cells. These biocompatible supramolecular anti-adhesives may potentially be used as immunotherapeutic or sensitizing agents to enhance antitumor effects of chemotherapy. 相似文献
39.
Galteland Olav Rauter Michael T. Bratvold Mina S. Trinh Thuat T. Bedeaux Dick Kjelstrup Signe 《Transport in Porous Media》2022,145(1):153-173
Transport in Porous Media - Darcy’s law for porous media transport is given a new local thermodynamic basis in terms of the grand potential of confined fluids. The local effective pressure... 相似文献
40.
Hue Thi Buu Bui Phuong Hong Nguyen Quan Minh Pham Hoa Phuong Tran De Quang Tran Hosun Jung Quang Vinh Hong Quoc Cuong Nguyen Quy Phu Nguyen Hieu Trong Le Su-Geun Yang 《Molecules (Basel, Switzerland)》2022,27(7)
Epigenetic alterations found in all human cancers are promising targets for anticancer therapy. In this sense, histone deacetylase inhibitors (HDACIs) are interesting anticancer agents that play an important role in the epigenetic regulation of cancer cells. Here, we report 15 novel hydroxamic acid-based histone deacetylase inhibitors with quinazolinone core structures. Five compounds exhibited antiproliferative activity with IC50 values of 3.4–37.8 µM. Compound 8 with a 2-mercaptoquinazolinone cap moiety displayed the highest antiproliferative efficacy against MCF-7 cells. For the HDAC6 target selectivity study, compound 8 displayed an IC50 value of 2.3 µM, which is 29.3 times higher than those of HDAC3, HDAC4, HDAC8, and HDAC11. Western blot assay proved that compound 8 strongly inhibited tubulin acetylation, a substrate of HDAC6. Compound 8 also displayed stronger inhibition activity against HDAC11 than the control drug Belinostat. The inhibitory mechanism of action of compound 8 on HDAC enzymes was then explored using molecular docking study. The data revealed a high binding affinity (−7.92 kcal/mol) of compound 8 toward HDAC6. In addition, dock pose analysis also proved that compound 8 might serve as a potent inhibitor of HDAC11. 相似文献