Innovative Eco-Friendly Hydrogel Film for Berberine Delivery in Skin Applications

Hydrogel formulations (masks or patches, without tissue support) represent the new frontier for customizable skin beauty and health. The employment of these materials is becoming popular in wound dressing, to speed up the healing process while protecting the affected area, as well as to provide a moisturizing reservoir, control the inflammatory process and the onset of bacterial development. Most of these hydrogels are acrylic-based at present, not biodegradable and potentially toxic, due to acrylic monomers residues. In this work, we selected a new class of cellulose-derived and biodegradable hydrogel films to incorporate and convey an active compound for dermatological issues. Films were obtained from a combination of different polysaccharides and clays, and berberine hydrochloride, a polyphenolic molecule showing anti-inflammatory, immunomodulatory, antibacterial and antioxidant properties, was chosen and then embedded in the hydrogel films. These innovative hydrogel-based systems were characterized in terms of water uptake profile, in vitro cytocompatibility and skin permeation kinetics by Franz diffusion cell. Berberine permeation fitted well to Korsmeyer–Peppas kinetic model and achieved a release higher than 100 µg/cm² within 24 h. The latter study, exploiting a reliable skin model membrane, together with the biological assessment, gained insights into the most promising formulation for future investigations.     

Superradiance in molecular H aggregates

Direct evidence of superradiance from an organic semiconductor (quaterthiophene) whose molecules are arranged in a H aggregate fashion, is reported. Time resolved photoluminescence measurements show a linear correlation between the radiative lifetime (tau(rad)) of the purely electronic exciton recombination and the inverse of the number (N(C)) of the coherently emitting dipoles, i.e., tau(rad) proportional, variant 1/N(C). These data support the recently developed theoretical models describing the optical properties of H aggregates of rodlike molecules with a nonvanishing component of the perpendicular molecular transition dipole moment.     

On the coherent states of a free electron laser

The coherence properties of the Free Electron Laser are examined both in the single mode and multimode case.     

Coherent states of a free electron laser

We define electron-field coherent quasi-classical states of a free electron laser. In these states both the photon number and the electron momentum are given by a Poisson distribution centered on the classical trajectories.     

Transverse effects in collective atomic recoil lasing

We investigate transverse effects in collective atomic recoil lasing (CARL), where a cold atomic sample is lightened by a far detuned laser beam resonant with the internal atomic transition. The gradient force of the scattered radiation field produces a collective self-focusing on the atoms, which could be observed in a Bose-Einstein condensate stored in a bidirectional optical ring cavity or in the superradiant CARL-BEC regime.     

Three-dimensional Wigner-function description of the quantum free-electron laser

A free-electron laser (FEL) operating in the quantum regime can provide a compact and monochromatic x-ray source. Here we present the complete quantum model for a FEL with a laser wiggler in three spatial dimensions, based on a discrete Wigner-function formalism taking into account the longitudinal momentum quantization. The model describes the complete spatial and temporal evolution of the electron and radiation beams, including diffraction, propagation, laser wiggler profile and emittance effects. The transverse motion is described in a suitable classical limit, since the typical beam emittance values are much larger than the Compton wavelength quantum limit. In this approximation we derive an equation for the Wigner function which reduces to the three-dimensional Vlasov equation in the complete classical limit. Preliminary numerical results are presented together with parameters for a possible experiment.