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61.
62.
We propose a new procedure for the construction of an invariant differentiation operator of a one-parameter group of local transformations in the space of one independent variable and m dependent variables. We prove that, for a known universal invariant, a complete set of functionally independent differential invariants of any order of this group can be constructed by using one quadrature and differentiation. The relationship between first-order differential invariants and systems of Riccati-type equations is analyzed. 相似文献
63.
Kolker D. B. Sherstov I. V. Boiko A. A. Kostyukova N. Yu. Erushin E. Yu. Pavlyuk A. V. 《Journal of Applied Spectroscopy》2022,89(4):742-747
Journal of Applied Spectroscopy - The generation regimes of quantum-cascade lasers for optoacoustic sensors of methane and ammonia are examined, and the tuning and output characteristics of these... 相似文献
64.
V.?R.?Akhmetova E.?M.?Bikbulatova N.?S.?Akhmadiev V.?M.?Yanybin T.?F.?Boiko R.?V.?Kunakova A.?G.?IbragimovEmail author 《Russian Journal of Organic Chemistry》2018,54(5):701-706
Catalytic aminomethylation of pyrrole and indole with N,N,N′,N′-tetramethylmethanediamine in the presence of 5 mol % of ZrOCl2·8H2O proceeds selectively at the positions 2, 5 of pyrrole and 1, 3 of indole. Carbazole under the same conditions affords 3-formyl-9-aminomethyl derivative. The reaction in the presence of 5 mol % of K2CO3 occurs as monoaminomethylation: for pyrrole at the position 2, for indole at the position 3, and for carbazole at the nitrogen atom of the substrate. Water-soluble 1,1′-(1H-pyrrole-2,5-diyl)bis(N,N-dimethylmethanamine) exhibits a fungistatic activity with respect to phytopathogenic fungi Rhizoctonia solani. 相似文献
65.
Frontispiece: Docking Strategy To Construct Thermostable,Single‐Crystalline,Hydrogen‐Bonded Organic Framework with High Surface Area
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66.
V.?I.?TishkovEmail author A.?A.?Pometun A.?V.?Stepashkina V.?V.?Fedorchuk S.?A.?Zarubina I.?S.?Kargov D.?L.?Atroshenko P.?D.?Parshin M.?D.?Shelomov R.?P.?Kovalevski K.?M.?Boiko M.?A.?Eldarov E.?D’Oronzo S.?Facheris F.?Secundo S.?S.?Savin 《Moscow University Chemistry Bulletin》2018,73(1):1-6
Majority of native enzymes are poorly applicable for practical usage: that is why different methods of enzyme modification are used to obtain the biocatalysts with appropriate characteristics. Development of genome sequencing and various modern approaches in protein engineering allow one to identify protein of interest and to improve the enzyme properties for a particular process. This review describes the results on development of novel biocatalysts based on bioinformatics and rational design. New genes encoding formate dehydrogenase (FDH) from bacterium Staphylococcus aureus, yeasts Ogataea parapolymorpha and Saccharomyces cerevisiae and moss Physcomitrella patens (SauFDH, OpaFDH, SceFDH and PpaFDH, respectively), have been cloned. New FDHs were produced in the active form and characterized. SauFDH was shown to have at least 2-fold higher catalytic constant than other known FDHs. OpaFDH has catalytic parameters as good as those for soy FDH mutant forms, and in addition, is more thermostable. Apo- and holo-forms of SauFDH have been crystallized. Mutation of two Cys residues in Pseudomonas sp.101 enzyme (PseFDH) yields enzyme preparations with improved kinetic parameters and enhanced thermal and chemical stability. New generation of PseFDH preparations with the coenzyme specificity changed from NAD+ to NADP+ have been obtained. The effect of ionic liquids on the catalytic properties and thermal stability of six wild-type recombinant FDHs, and a number of their mutants, have been studied. In case of D-amino acid oxidase (DAAO), single-point mutations have been combined to create multi-point mutants. The introduced amino acid replacements have been shown to exert an additive effect, improving both kinetic parameters and increasing thermal and chemical stability. DAAO genes from Hansenula polymorpha yeast have been cloned. α-Amino acid ester hydrolase (AEH) gene has been cloned and expressed in the active form in E. coli. Structural modeling has been performed and the effectiveness in amino beta-lactams synthesis studied. The structure of a single-chain penicillin acylase from Alcaligenes faecalis (scAfPA) has been modeled and two variants of scAfPA gene was generated by PCR. Both variants have been expressed in E. coli, isolated and characterized. Catalytic properties of scAfPA were slightly better than those of its natural heterodimer. 相似文献
67.
Domenici V Cifelli M Veracini CA Boiko NI Agina EV Shibaev VP 《The journal of physical chemistry. B》2008,112(47):14718-14728
A complete Deuterium NMR study performed on partially deuterated liquid crystalline carbosilane dendrimer is here reported. The dendrimer under investigation shows a SmA phase in a large temperature range from 381 to 293 K, and its mesophasic properties have been previously determined. However, in this work the occurrence of a biphasic region between the isotropic and SmA phases has been put in evidence. The orientational order of the dendrimer, labeled on its lateral mesogenic units, is here evaluated in the whole temperature range by means of (2)H NMR, revealing a peculiar trend at low temperatures (T < 326 K). This aspect has been further investigated by a detailed analysis of the (2)H NMR spectral features, such as the quadrupolar splitting, the line shape, and the line-width, as a function of temperature. In the context of a detailed NMR analysis, relaxation times (T(1) and T(2)) have also been measured, pointing out a slowing down of the dynamics by decreasing the temperature, which determines from one side the spectral changes observed in the NMR spectra, on the other the observation of a minimum in the T(1). 相似文献
68.
Organero JA Martin C Cohen B Douhal A 《Langmuir : the ACS journal of surfaces and colloids》2008,24(18):10352-10357
We report studies of the interaction between a proton-transfer dye (1'-hydroxy,2'-acetonaphthone, HAN), with the human serum albumin (HSA) protein and a beta-cyclodextrin derivative (DM-beta-CD) in neutral water solutions. We used steady-state and picosecond time-resolved emission spectroscopy to follow the structural changes of HAN due to the hydrophobicity and confinement effect of these nanocavities. Upon encapsulation, the fluorescence intensity of the 1:1 inclusion complex in both cavities increases, and the emission lifetimes become longer. For the DM-beta-CD complexes, we obtained 430 and 920 ps, whereas for the HSA complexes we obtained 630 ps and 2 ns. Picosecond anisotropy measurements show strong confinement due to protein docking. The rotational time for the CD complex is 660 ps, whereas for the protein complex we find 6 ns. The process of energy transfer from the excited triptophan 214 (Trp214) of HSA to the trapped HAN occurs with high efficiency (71%), and the calculated distance between both chromophores is 17 A. We believe that the results are important for a better understanding of the processes occurring in inclusion complexes such as those in nanopharmacodynamics. 相似文献
69.
Ya. S. Samosudova A. V. Markin N. N. Smirnova T. G. Ogurtsov N. I. Boiko V. P. Shibaev 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2016,90(11):2129-2135
The temperature dependence of the heat capacity of a first-generation liquid crystal carbosilane dendrimer with methoxyphenyl benzoate end groups is studied for the first time in the region of 6–370 K by means of precision adiabatic vacuum calorimetry. Physical transformations are observed in this interval of temperatures, and their standard thermodynamic characteristics are determined and discussed. Standard thermodynamic functions Cp°(T), H°(T) ? H°(0), S°(T) ? S°(0), and G°(T) ? H°(0) are calculated from the obtained experimental data for the region of Т → 0 to 370 K. The standard entropy of formation of the dendrimer in the partially crystalline state at Т = 298.15 K is calculated, and the standard entropy of the hypothetic reaction of its synthesis at this temperature is estimated. The thermodynamic properties of the studied dendrimer are compared to those of second- and fourth-generation liquid crystal carbosilane dendrimers with the same end groups studied earlier. 相似文献
70.
The results of experimental and numerical investigations of the efficiency of control by an incompressible turbulent boundary layer with the help air blowing through a permeable wall fabricated with maintenance of most of the necessary requirements for the quality and configuration of microapertures and having a low effective roughness are analyzed. Various cases of modeling the process of air blowing into the boundary layer through a specified hi-tech finely perforated surface are considered, and the data for average parameters and characteristics of turbulence of the flow types under investigation are presented. A substantial decrease in the skin-friction coefficient along the model length, which can achieve 90% with increasing the blowing coefficient, is shown. The estimate of the energy consumption for the process of blowing under terrestrial conditions testifies to the high potential of this method of control capable to provide 4–5% gain in the total aerodynamic drag of a simple modeling configuration. 相似文献