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以国产交联琼脂糖6FF为基质,分别以环氧氯丙烷(ECH)、1,4-丁二醇二缩水甘油醚(BDGE)为活化剂,偶联谷胱甘肽(GSH)得到两种连接臂长度不同的GSH亲和层析介质,并以两种自制介质对融合蛋白GST-ADAM15进行了纯化。结果表明:GSH-ECH-琼脂糖凝胶和GSH-BDGE-琼脂糖凝胶的配基密度分别达到了30~35μmol/mL和15~18μmol/mL,经两种介质纯化后的GST融合蛋白,纯度均达到95%以上,BDGE活化对目标蛋白的回收率占总蛋白26%,ECH活化为13%。相对而言,由于连接臂长度的不同,BDGE活化的介质纯化效果优于ECH。 相似文献
23.
Many neurodegenerative disorders are induced by protein conformational change. Prion diseases are characterized by protein conformational conversion from a normal cellular form (PrP(C)) to an abnormal scrapie isoform (PrP(Sc)). PrP106-126 is an accepted model for studying the characteristics of PrP(Sc) because they share many biological and physiochemical properties. To understand how metal complexes affect the property of the prion peptide, the present work investigated interactions between Pd complexes and PrP106-126 based on our previous research using Pt and Au complexes to target the peptide. The selected compounds (Pd(phen)Cl(2), Pd(bipy)Cl(2), and Pd(en)Cl(2)) showed strong binding affinity to PrP106-126 and affected the conformation and aggregation of this active peptide in a different binding mode. Our results indicate that it may be the metal ligand-induced spatial effect rather the binding affinity that contributes to better inhibition on peptide aggregation. This finding would prove valuable in helping design and develop novel metallodrugs against prion diseases. 相似文献
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论文采用断裂力学中的内聚力模型,结合有限元法研究裂纹沿牙本质小管和垂直于牙本质小管扩展的断裂韧度.数值模拟结果表明牙本质的断裂韧度随着裂纹扩展而增大,表现出上升的阻力曲线(R-curve)特性,但裂纹沿牙本质小管扩展的断裂韧度要大于裂纹垂直于牙本质小管扩展的断裂韧度,表现出各向异性的裂纹扩展阻力曲线性质.同时论文的研究... 相似文献
26.
A scheme for photonic generation of ultra-wideband (UWB) pulses using a semiconductor optical amplifier (SOA) and an electro-absorber (EA) in parallel is proposed and numerically demonstrated. By adjusting the time delay between two pump signals incident into the SOA and the EA, we can obtain monocycle pulses with reversed polarities and different bandwidths. The proposed method is flexible in pulse shaping and easy in practical optimization. 相似文献
27.
Hongwei Wu Zhao Chen Weijie Chi Anivind Kaur Bindra Long Gu Cheng Qian Bing Wu Bingbing Yue Guofeng Liu Guangbao Yang Liangliang Zhu Yanli Zhao 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(33):11541-11545
Developing molecules with high emission efficiency both in solution and the solid state is still a great challenge, since most organic luminogens are either aggregation‐caused quenching or aggregation‐induced emission molecules. This dilemma was overcome by integrating planar and distorted structures with long alkyl side chains to achieve DAπAD type emitters. A linear diphenyl–diacetylene core and the charge transfer effect ensure considerable planarity of these molecules in the excited state, allowing strong emission in dilute solution (quantum yield up to 98.2 %). On the other hand, intermolecular interactions of two distorted cyanostilbene units restrict molecular vibration and rotation, and long alkyl chains reduce the quenching effect of the π–π stacking to the excimer, eventually leading to strong emission in the solid state (quantum yield up to 60.7 %). 相似文献
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Yuan‐Yuan Che Yanni Yue Ling‐Zhi Lin Bingbing Pei Xuezu Deng Chao Feng 《Angewandte Chemie (International ed. in English)》2020,59(38):16414-16419
Herein, we report a highly efficient and practical method for pyridine‐derived heterobiaryl synthesis through palladium‐catalyzed electrophilic functionalization of easily available pyridine‐derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon‐based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described. 相似文献
29.
Yuan-Yuan Che Yanni Yue Ling-Zhi Lin Bingbing Pei Xuezu Deng Prof. Dr. Chao Feng 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(38):16556-16561
Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described. 相似文献
30.
Bingbing Shi Zhengtao Li Yuezhou Liu Liqing Shangguan Huangtianzhi Zhu Huaqiang Ju Feihe Huang 《Tetrahedron letters》2018,59(38):3477-3480
Here we report the design and syntheses of two new triptycene-based rigid acyclic C-shaped hosts, clip[5]arenes C[5]OH and C[5]ME, and the strong host–guest complexation between C[5]OH and an electron-poor bipyridinium salt, paraquat G. The Ka value for the host–guest complex C[5]OH???G was calculated to be (1.09?±?0.36)??×??105?M?1 in acetone by using a non-linear curve-fitting method based on the UV–vis absorption titration experiments. Furthermore, based on this new host–guest recognition motif, a novel pseudopolyrotaxane-like supramolecular structure was constructed with C[5]OH threaded on polyviologen polymer VP-10. 相似文献