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31.
Smita A Ghanekar Sonny Bhatia Joyce J Ruitenberg DeLa Corazon Rosa Mary L Disis Vernon C Maino Holden T Maecker Cory A Waters 《Journal of immune based therapies and vaccines》2007,5(1):7-14
Background
Monocyte-derived-dendritic-cells (MDDC) are the major DC type used in vaccine-based clinical studies for a variety of cancers. In order to assess whether in vitro differentiated MDDC from cryopreserved PBMC of cancer patients are functionally distinct from those of healthy donors, we compared these cells for their expression of co-stimulatory and functional markers. In addition, the effect of cryopreservation of PBMC precursors on the quality of MDDC was also evaluated using samples from healthy donors. 相似文献32.
The stability of a horizontal layer of fluid heated from below as well as from above is examined. The temperature gradient between the walls of the fluid layer consists of a steady part and a time-dependent part, which is oscillatory. The amplitude of temperature modulation is δ. By considering the weakly non-linear analysis, it is shown that the modulation produces a range of stable hexagons near the critical Rayleigh number. Some comparisons have been made with the other theoretical results. 相似文献
33.
S. B. Beri K. B. Bhalla R. Bhanja A. Bharti V. S. Bhatia G. Claesson S. Garpman S. K. Gupta V. K. Gupta N. Y. Herrstrom B. Jakobsson R. Joseph G. L. Kaul G. Kaur M. Kaur S. Kitroo V. Kumar S. Lokanathan I. Lund L. K. Mangotra I. S. Mitra S. Mookerjee B. Norén A. Oskarsson I. Otterlund Y. Prakash S. Persson N. K. Rao S. Sankhyadhar S. Satti M. M. Sherif K. Söderström S. K. Tuli 《Zeitschrift für Physik A Hadrons and Nuclei》1987,327(4):431-441
40Ar-emulsion interactions are studied, to investigate the question of anomalons, in twoG- 5 emulsion stacks. In about 4600 primary interactions, projectile fragments of Z≧2 for all generations have been followed until they interact or leave the stack. After careful estimation of charges of these fragments, variation of their mean free paths is studied as a function of distance from the preceding interaction. Generation effect,N h dependence and production angle effect are investigated. In addition multi-chain events are analysed separately. Our results do not show anomalons at the 6% level and are consistent with non-occurrence of anomalons. However, this experiment is not sensitive enough to rule out anomalons (with a mfp of the order of 2 to 3 cm) produced at about 1% (or less) level. 相似文献
34.
Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells
Bishayee A Háznagy-Radnai E Mbimba T Sipos P Morazzoni P Darvesh AS Bhatia D Hohmann J 《Natural product communications》2010,5(10):1613-1618
Dietary antioxidants, such as anthocyanins, are helpful in the prevention and control of various diseases by counteracting the imbalance of oxidative and antioxidative factors in the living systems. Black currant (Ribes nigrum L., Grossulariaceae) is known to contain high amounts of anthocyanins (250 mg/100 g fresh fruit). Black currant fruits have been used in Asian and European traditional medicine for the treatment of a variety of diseases. Black currant extract has recently been found to be the second most effective amongst nine different berry extracts studied for their free radical scavenging activity. Constituents present in black currant juice have been found to exert a number of health-promoting effects, including immunomodulatory, antimicrobial and antiinflammatory actions, inhibition of low-density lipoprotein, and reduction of cardiovascular diseases. Although antioxidant and antiinflammatory effects of black currant juice could be of value in preventing and treating oxidative stress- and inflammation-driven cancers, no experimental evidence is available to now. The objective of the present study was to evaluate the potential antiproliferative effects of black currant fruit skin extract against HepG2 human liver cancer cells. The aqueous extract yielded an anthocyanin-rich fraction with cyanidin-3-O-rutinoside as one of the major anthocyanins. This fraction exhibited a potent cytotoxic effect on HepG2 cells and this effect was more pronounced than that of delphinidin and cyanidin, two major aglycones of anthocyanins present in black currant. Our results indicate, for the first time, that black currant skin containing an anthocyanin-rich fraction inhibits the proliferation of liver cancer cells, possibly due to additive as well as synergistic effects. This product could be useful in the prevention and treatment of human hepatocellular carcinoma. 相似文献
35.
J. Adam Chitra Bhatia K. Katovsky V. Kumar M. Majerle V. S. Pronskikh A. M. Khilmanovich B. A. Martsynkevich I. V. Zhuk V. M. Golovatiouk W. Westmeier A. A. Solnyshkin V. M. Tsoupko-Sitnikov A. S. Potapenko 《The European Physical Journal A - Hadrons and Nuclei》2011,47(7):1-18
Spallation neutrons produced in the collision of a 2.33GeV deuteron beam with a large lead target are moderated by a thick graphite block surrounding the target and used to activate the radioactive samples of natU and Th put at three different positions, identified as holes “a”, “b” and “c” in the graphite block. Rates of the (n, f), (n, $ \gamma$ and (n, 2n) reactions in the two samples are determined using the gamma spectrometry. The ratios of the experimental reaction rates, R (n, 2n)/R (n, f), for 232Th and natU are estimated in order to understand the role of the (n, x n) kind of reactions in Accelerator-Driven Sub-critical Systems. For the Th-sample, the ratio is ~ 54 (10)% in the case of hole “a” and ~ 95 (57)% in the case of hole “b” compared to 1.73(20)% for hole “a” and 0.710(9)% for hole “b” in the case of the natU sample. Also the ratio of fission rates in uranium to thorium, natU (n, f)/ 232Th (n, f), is ~ 11.2 (17) in the case of hole “a” and 26.8(85) in hole “b”. Similarly, the ratio 238U (n, 2n)/ 232Th (n, 2n) is 0.36(4) for hole “a” and 0.20(10) for hole “b” showing that 232Th is more prone to the (n, x n) reaction than 238U . All the experimental reaction rates are compared with the simulated ones by generating neutron fluxes at the three holes from MCNPX 2.6c and making use of the LA150 library of cross-sections. The experimental and calculated reaction rates of all the three reactions are in reasonably good agreement. The transmutation power, P norm as well as P norm/P beam of the set-up is estimated using the reaction rates of the (n, $ \gamma$ and (n, 2n) reactions for both the samples in the three holes and compared with some of the results of the “Energy plus Transmutation” set-up and TARC experiment. 相似文献
36.
Densities ρ, speeds of sound u, viscosities η and refractive indices nD of binary mixtures of octan-2-ol with benzene, chlorobenzene and bromobenzene have been measured over the entire range of composition at 298.15 and 303.15 K and atmospheric pressure. From the experimental data, excess molar volumes VE, isentropic compressibilities κS, excess isentropic compressibilities κSE, and deviations of speeds of sound uD, have been calculated at 298.15 and 303.15 K. These excess functions have been fitted to the Redlich-Kister polynomial equation. The viscosity data have been correlated using Kendall-Monroe, Grunberg-Nissan, Tamura-Kurata, Hind-Mclaughlin Ubbelohde and Katti-Chaudhary viscosity models, and McAllister's three-body interaction model at different temperatures. 相似文献
37.
Lead sulfide has been found to form stable glasses with GeS2 in the presence of GeS. Far-infrared transmission spectra of the glassy compositions x = 0.46, 0.23 and 0.115 in the pseudoternary (PbS)x (GeS2)0.70?x (GeS)0.30 and of the stoichiometric crystalline composition Pb2GeS4 have been observed for the first time. The results indicate a two optical mode behaviour of the compounds. The presence of the heavy lead atom in the GeS network seems to appreciably affect the bond bending modes of the GeS4 molecular unit without significantly disturbing its bond stretching vibrations. The presence of S3GeGeS3 molecular units in the amorphous compositions and their absence in Pb2GeS4 are indicated. 相似文献
38.
Cobalt(II) complexes 1 or 2, catalyses the epoxidation of alkenes in the presence of molecular oxygen and 2-methylpropanal in high yields. 相似文献
39.
In this paper, stability of a parametric quasivariational inequality of the Minty type is studied via various sufficient conditions
characterizing upper and lower semicontinuity of the solution sets as well as the approximate solution sets. Sufficient conditions
ensuring upper semicontinuity of the approximate solution sets of an optimization problem with quasivariational inequality
constraints are also presented. 相似文献
40.
Inderpreet Singh A. Verma I. Kaur L. M. Bharadwaj V. Bhatia V. K. Jain C. S. Bhatia P. K. Bhatnagar P. C. Mathur 《Journal of Polymer Science.Polymer Physics》2010,48(1):89-95
DC conductivity of conjugated polymer‐single‐walled carbon nanotube (SWNT) composite films has been measured for different SWNT concentrations. The composite was prepared by dispersing SWNTs in the poly (3‐octylthiophene), P3OT matrix already dissolved in xylene. The conductivity of the composite films showed a rapid increase as the SWNT concentration increases beyond a certain value. This behavior is explained in terms of percolating paths provided by the SWNTs in the volume of polymer matrix. To investigate the effect of length of nanotubes on the percolation conductivity, different SWNT samples were employed with similar diameter but varying tube lengths. It was found that the conductivity of the composite films is strongly dominated by the length of the nanotubes. Lower percolation limit and high conductivity value of composite films is observed for longer nanotubes. Furthermore, the conductivity is observed to be dependent on the size of the host polymer molecule also. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 89–95, 2010 相似文献