全文获取类型
收费全文 | 407篇 |
免费 | 22篇 |
专业分类
化学 | 168篇 |
力学 | 27篇 |
数学 | 152篇 |
物理学 | 82篇 |
出版年
2022年 | 6篇 |
2021年 | 2篇 |
2020年 | 5篇 |
2019年 | 7篇 |
2018年 | 7篇 |
2017年 | 7篇 |
2016年 | 16篇 |
2015年 | 10篇 |
2014年 | 18篇 |
2013年 | 11篇 |
2012年 | 25篇 |
2011年 | 28篇 |
2010年 | 16篇 |
2009年 | 12篇 |
2008年 | 33篇 |
2007年 | 21篇 |
2006年 | 23篇 |
2005年 | 18篇 |
2004年 | 16篇 |
2003年 | 15篇 |
2002年 | 11篇 |
2001年 | 6篇 |
2000年 | 13篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 5篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 5篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1978年 | 2篇 |
1976年 | 7篇 |
1975年 | 9篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1971年 | 2篇 |
1970年 | 1篇 |
1969年 | 7篇 |
1968年 | 1篇 |
1967年 | 3篇 |
1965年 | 1篇 |
排序方式: 共有429条查询结果,搜索用时 15 毫秒
421.
We study the behavior of thin elastic sheets that are bent and strained under a weak, smooth confinement. We show that the emerging shapes exhibit the coexistence of two types of domains. A focused-stress patch is subject to a geometric, piecewise-inextensibility constraint, whereas a diffuse-stress region is characterized by a mechanical constraint-the dominance of a single component of the stress tensor. We discuss the implications of our findings for the analysis of elastic sheets under various types of forcing. 相似文献
422.
Michael Krivelevich Benny Sudakov Nicholas Wormald 《Random Structures and Algorithms》2011,38(3):235-250
An old problem of Erd?s, Fajtlowicz, and Staton asks for the order of a largest induced regular subgraph that can be found in every graph on vertices. Motivated by this problem, we consider the order of such a subgraph in a typical graph on vertices, i.e., in a binomial random graph . We prove that with high probability a largest induced regular subgraph of has about vertices. © 2010 Wiley Periodicals, Inc. Random Struct. Alg., 38, 235–250, 2011 相似文献
423.
Diamines were found to promote catalytic conjugate addition of α-cyano active methine nucleophiles to various acrylate derivatives. 相似文献
424.
Kneissl B Mueller SC Tautermann CS Hildebrandt A 《Journal of chemical information and modeling》2011,51(11):3017-3025
The reasons for distortions from optimal α-helical geometry are widely unknown, but their influences on structural changes of proteins are significant. Hence, their prediction is a crucial problem in structural bioinformatics. For the particular case of kink prediction, we generated a data set of 132 membrane proteins containing 1014 manually labeled helices and examined the environment of kinks. Our sequence analysis confirms the great relevance of proline and reveals disproportionately high occurrences of glycine and serine at kink positions. The structural analysis shows significantly different solvent accessible surface area mean values for kinked and nonkinked helices. More important, we used this data set to validate string kernels for support vector machines as a new kink prediction method. Applying the new predictor, about 80% of all helices could be correctly predicted as kinked or nonkinked even when focusing on small helical fragments. The results exceed recently reported accuracies of alternative approaches and are a consequence of both the method and the data set. 相似文献
425.
Šebek J Pele L Potma EO Gerber RB 《Physical chemistry chemical physics : PCCP》2011,13(28):12724-12733
First-principles anharmonic vibrational calculations are carried out for the Raman spectrum of the C-H stretching bands in dodecane, and for the C-D bands in the deuterated molecule. The calculations use the Vibrational Self-Consistent Field (VSCF) algorithm. The results are compared with liquid-state experiments, after smoothing the isolated-molecule sharp-line computed spectra. Very good agreement between the computed and experimental results is found for the two systems. The combined theoretical and experimental results provide insights into the spectrum, elucidating the roles of symmetric and asymmetric CH(3) and CH(2) hydrogenic stretches. This is expected to be very useful for the interpretation of spectra of long-chain hydrocarbons. The results show that anharmonic effects on the spectrum are large. On the other hand, vibrational degeneracy effects seem to be rather modest at the resolution of the experiments. The degeneracy effects may have more pronounced manifestations in higher-resolution experiments. The results show that first-principles anharmonic vibrational calculations for hydrocarbons are feasible, in good agreement with experiment, opening the way for applications to many similar systems. The results may be useful for the analysis of CARS imaging of lipids, for which dodecane is a representative molecule. It is suggested that first-principles vibrational calculations may be useful also for CARS imaging of other systems. 相似文献
426.
Shui G Cheong WF Jappar IA Hoi A Xue Y Fernandis AZ Tan BK Wenk MR 《Journal of chromatography. A》2011,1218(28):4357-4365
Direct measurement of various sterols in crude lipid extracts in a single experiment from limited biological samples is challenging. Current mass spectrometry (MS) based approaches usually require chemical derivatization before subjecting to MS analysis. Here, we present a derivatization-independent method for analyzing various sterols, including cholesterol and its congeners, using liquid chromatography and atmospheric pressure chemical ionization mass spectrometry. Based on the specific tandem mass spectrometry pattern of cholesterol, multiple reaction monitoring (MRM) transitions were used to quantify free cholesterol and its fatty acyl esters. Several cholesterol oxidation products could also be measured using the upfront liquid chromatography separation and specific MRM transitions. The method was validated alongside established enzymatic assays in measuring total cholesterol. As a proof of concept, we analyzed plasma sterols in rabbits administrated with a high cholesterol diet (HCD) which is a classical atherosclerotic model. Free cholesterol, cholesterol esters, 7-hydroxycholesterol, and 7-ketocholesterol were elevated in plasma of rabbits on HCD. This method could also serve as an excellent tool for quantitative analysis of other sterols such as ergosterol and sitosterol in other organisms beside mammalian. In Saccharomyces cerevisiae, our results indicated dramatic increases of the ratio of ergosterol esters to free ergosterol in both yeh2Δ and tgl1Δ cells, which are consistent with the function of the respective enzymes. 相似文献
427.
The purpose of the study is to numerically, experimentally, and analytically investigate the characteristics of plasma pulsed thermal actuators (PT actuators) and to assess their possibilities in controlling flow around airfoils, wings, and configurations at large subsonic freestream velocities. For the PT actuators of the types considered the mathematical models adequately describing their effect on flow past bodies are developed. The characteristics of a prototype PT actuator are experimentally investigated on a specially developed rig. A new type of the PT actuator equippedwith a channel (PTC actuator) is proposed; it is designed to operate at a high pulse repetition frequency and at large flow velocities. Numerical investigations show that the PTC actuators are free of the essential and fundamental shortcoming of the PT actuators which consists in the working zone superheating at high pulse repetition frequencies. 相似文献
428.
Wen-Chieh Liao Rou-An Yao Li-You Chen Ting-Yi Renn Igor V. Klimenkov Nikolay P. Sudakov Fu-Der Mai Yea-Tzy Chen Hung-Ming Chang 《Molecules (Basel, Switzerland)》2022,27(21)
Visceral pain (VP) is the organ-derived nociception in which increased inflammatory reaction and exaggerated activation of the central nucleus of the amygdala (CeA) may contribute to this deficiency. Considering the amygdala also serves as the integration center for olfaction, the present study aimed to determine whether olfactory stimulation (OS) would effectively depress over-activation and inflammatory reaction in CeA, and successfully relieve VP-induced abnormalities. Adult rats subjected to intraperitoneal injection of acetic acid inhaled lavender essential oil for 2 or 4 h. The potential benefits of OS were determined by measuring the pro-inflammatory cytokine level, intracellular potassium and the upstream small-conductance calcium-activated potassium (SK) channel expression, together with detecting the stress transmitters that participated in the modulation of CeA activity. Results indicated that in VP rats, strong potassium intensity, reduced SK channel protein level, and increased corticotropin-releasing factor, c-fos, and substance P immuno-reactivities were detected in CeA. Enhanced CeA activation corresponded well with increased inflammatory reaction and decreased locomotion, respectively. However, in rats subjected to VP and received OS, all above parameters were significantly returned to normal levels with higher change detected in treating OS of 4h. As OS successfully depresses inflammation and CeA over-activation, application of OS may serve as an alternative and effective strategy to efficiently relieve VP-induced deficiency. 相似文献
429.
Dr. Laura M. McCaslin Dr. Andreas W. Götz Prof. Mark A. Johnson Prof. R. Benny Gerber 《Chemphyschem》2023,24(5):e202300085
The reaction of N2O5 at atmospheric interfaces has recently received considerable attention due to its importance in atmospheric chemistry. N2O5 reacts preferentially with Cl− to form ClNO2/NO3− (Cl− substitution), but can also react with H2O to form 2HNO3 (hydrolysis). In this paper, we explore these competing reactions in a theoretical study of the clusters N2O5/Cl−/nH2O (n=2–5), resulting in the identification of three reaction motifs. First, we uncovered an SN2-type Cl− substitution reaction of N2O5 that occurs very quickly due to low barriers to reaction. Second, we found a low-lying pathway to hydrolysis via a ClNO2 intermediate (two-step hydrolysis). Finally, we found a direct hydrolysis pathway where H2O attacks N2O5 (one-step hydrolysis). We find that Cl− substitution is the fastest reaction in every cluster. Between one-step and two-step hydrolysis, we find that one-step hydrolysis barriers are lower, making two-step hydrolysis (via ClNO2 intermediate) likely only when concentrations of Cl− are high. 相似文献