全文获取类型
收费全文 | 519篇 |
免费 | 39篇 |
专业分类
化学 | 485篇 |
力学 | 3篇 |
数学 | 16篇 |
物理学 | 54篇 |
出版年
2023年 | 10篇 |
2022年 | 6篇 |
2021年 | 14篇 |
2020年 | 18篇 |
2019年 | 27篇 |
2017年 | 4篇 |
2016年 | 22篇 |
2015年 | 16篇 |
2014年 | 20篇 |
2013年 | 15篇 |
2012年 | 33篇 |
2011年 | 31篇 |
2010年 | 14篇 |
2009年 | 19篇 |
2008年 | 28篇 |
2007年 | 21篇 |
2006年 | 25篇 |
2005年 | 24篇 |
2004年 | 9篇 |
2003年 | 14篇 |
2002年 | 21篇 |
2001年 | 14篇 |
2000年 | 7篇 |
1999年 | 13篇 |
1998年 | 9篇 |
1997年 | 16篇 |
1996年 | 13篇 |
1995年 | 2篇 |
1994年 | 6篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 6篇 |
1988年 | 4篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 7篇 |
1982年 | 5篇 |
1981年 | 8篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 2篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1972年 | 2篇 |
1918年 | 4篇 |
1909年 | 3篇 |
1903年 | 2篇 |
排序方式: 共有558条查询结果,搜索用时 15 毫秒
531.
M. Sc. Benedikt Waerder Dipl.‐Chem. Simon Steinhauer Beate Neumann Dr. Hans‐Georg Stammler Dr. Andreas Mix Dr. Yury V. Vishnevskiy Prof. Dr. Berthold Hoge Prof. Dr. Norbert W. Mitzel 《Angewandte Chemie (International ed. in English)》2014,53(43):11640-11644
Lithium carbenoids are versatile compounds for synthesis owing to their intriguing ambiphilic behavior. Although this class of compounds has been known for several years, few solid‐state structures exist because of their high reactivity and often low thermal stability. Using cryo X‐ray techniques, we were now able to elucidate the first solid‐state structure of a Li/F alkyl carbenoid, pentafluoroethyllithium (LiC2F5), finally yielding a prototype for investigating structure—reactivity relationships for this class of molecules. The compound forms a diethyl ether‐solvated dimer bridged by a rare C–F–Li link. Complementary NMR spectroscopy studies in solution show dynamic processes and indicate rapid exchange of starting material and product. Theoretical investigations help to understand the formation of the observed unusual structural motif. 相似文献
532.
Beate Fuchs 《Analytical and bioanalytical chemistry》2014,406(5):1291-1306
Many diseases such as arthritis or atherosclerosis are accompanied by inflammatory processes. Inflammation is characterized by the infiltration of cells such as neutrophilic granulocytes and (a) the release of phospholipases [particularly phospholipase A2 (PLA2)] and (b) the generation of reactive oxygen as well as nitrogen species (ROS and RNS). While PLA2 leads to defined lyso products (lacking one acyl residue), lipid oxidation is characterized by much more complex product patterns, including lipid peroxides, aldehydes (by double bond cleavage), and many others. Nevertheless, oxidation processes are highly important under in vivo conditions because molecules with regulatory functions are generated by the oxidation of lipids and/or free fatty acids. Therefore, lipid oxidation products as well as lysolipids are increasingly assumed to represent important disease (bio)markers. Consequently, there is also increasing interest in methods to characterize these products qualitatively and quantitatively. Mass spectrometry (MS) seems to be the method of choice to study (phospho)lipids changed under inflammatory conditions: nowadays, soft ionization MS methods are regularly used to study oxidative lipid modifications because of their high sensitivities and the tremendous mass resolutions that are achievable by using modern mass spectrometers. However, experimental care is required to be able to detect all relevant products. Although electrospray ionization (ESI) MS is so far most popular, applications of matrix-assisted laser desorption and ionization (MALDI) MS are continuously increasing. This review aims to summarize the so far available data on MS analyses of oxidized lipids as well as lysolipids. In addition to model systems, special attention will be paid to the monitoring of oxidized lipids and lysolipids under in vivo conditions. It is the aim of this review to provide a critical survey of the advantages and drawbacks of the different MS methods, with the focus on MALDI and ESI. Figure
Scheme of mass spectrometric analysis to study oxidation and enzyme-modified phospholipids changed under inflammatory conditions 相似文献
533.
We have combined an embedded-cluster model with an extension of the method of increments to treat the adsorption of molecules on a surface. In this way we are able to investigate the physisorption of CO on CeO(2)(110) at the MP2, MP4(SDTQ), and CCSD(T) levels with only moderate computational costs. We find that, at the CCSD(T) level, 25% of the adsorption energy originates from electron correlation. The interactions of the CO molecule with its five nearest cerium and oxygen neighbors in the surface layer make the largest contributions to the electron correlation. Approximately 97% of the adsorption-induced electron correlation energy part of the adsorption energy is recovered by the method of increments (in our chosen expansion), at the MP2 level. 相似文献
534.
Vetere V Monari A Bendazzoli GL Evangelisti S Paulus B 《The Journal of chemical physics》2008,128(2):024701
The precursor of the metal-insulator transition is studied at ab initio level in linear chains of equally spaced lithium atoms. In particular, full configuration interaction calculations (up to 1 x 10(9) determinants) are performed, in order to take into account the different nature of the wave function at different internuclear distances. Several indicators of the Metal-Insulator transition (minimum of the energy gap, maximum of the localization tensor or of the polarizability) are considered and discussed. It is shown that the different indicators give concordant results, showing a rapid change in the nature of the wave function at an internuclear distance of about 7 bohrs. 相似文献
535.
The linear absorbance of a particular chromophore complex P(4) dissolved in ethanol is computed. P(4) is formed by a butanediamine dendrimer to which four pheophorbide-a molecules are covalently linked. The computations utilize a mixed quantum classical methodology and different approximations are compared. The electronic states of the P(4) chromophores which form Frenkel excitons in the excited states are treated quantum mechanically, whereas the intramolecular, intermolecular, as well as solvent coordinates are described classically. The computations use an improved exciton model, where the charge and transition densities of the chromophores are described by atomic partial charges, derived from a fit of the respective ab initio electrostatic potentials. Room temperature molecular dynamics simulations of all nuclear coordinates result in a time-dependent exciton model. It includes modulations of chromophore excitation energies due to charge density coupling between all chromophores as well as between the chromophores and solvent molecules, and, finally, modulations of the interchromophore excitonic couplings. The different approximations to the absorbance agree rather well. In particular, they confirm the reliability of adiabatic excitonic states which energies and oscillator strengths are altered by the overall temporal evolution of P(4) conformations. The fluctuations of solute-solvent interactions have a significantly larger effect on the absorbance broadening than the excitonic couplings but cannot completely explain the measured spectrum. The additional account for intrachromophore vibrations overcomes this discrepancy. 相似文献
536.
Jie Liu Shubhadip Mallick Yusheng Xie Corentin Grassin Belén Lucas Beate Schölermann Axel Pahl Rebecca Scheel Carsten Strohmann Christoph Protzel Thorsten Berg Christian Merten Slava Ziegler Herbert Waldmann 《Angewandte Chemie (International ed. in English)》2023,62(21):e202301955
Oxindoles and iso-oxindoles are natural product-derived scaffolds that provide inspiration for the design and synthesis of novel biologically relevant compound classes. Notably, the spirocyclic connection of oxindoles with iso-oxindoles has not been explored by nature but promises to provide structurally related compounds endowed with novel bioactivity. Therefore, methods for their efficient synthesis and the conclusive discovery of their cellular targets are highly desirable. We describe a selective RhIII-catalyzed scaffold-divergent synthesis of spirooxindole–isooxindoles and spirooxindole–oxindoles from differently protected diazooxindoles and N-pivaloyloxy aryl amides which includes a functional group-controlled Lossen rearrangement as key step. Unbiased morphological profiling of a corresponding compound collection in the Cell Painting assay efficiently identified the mitotic kinesin Eg5 as the cellular target of the spirooxindoles, defining a unique Eg5 inhibitor chemotype. 相似文献
537.
The effect of electron-correlation on the ground-state properties of CeN and LaN is studied by ab initio quantum-chemical methods. The approach which is used combines two separate steps: (1) the ground-state Hartree-Fock calculations for the crystal; (2) application of the method of increments to the studied system, which allows an expansion of bulk properties using the information from quantum-chemical calculations performed for finite clusters. As can be expected, for CeN correlation plays a significant role: with Hartree-Fock method only 49% of the experimental cohesive energy has been recovered, whereas after correlation corrections (coupled-cluster approach) the ground-state properties were found to be in good agreement with the experimental data found in literature. Thus, we obtained about 90% of the expected cohesive energy; the computed lattice constants and bulk moduli also agree well with the experimental values. For comparison, the equivalent treatment has been performed for LaN, where no f orbital is occupied. There the HF contribution to the ground-state properties is larger and hence the correlation effects weaker. 相似文献
538.
Farias PM Santos BS Thomaz AA Ferreira R Menezes FD Cesar CL Fontes A 《The journal of physical chemistry. B》2008,112(9):2734-2737
In this work we used a setup consisting of an optical tweezers combined with a nonlinear microspectroscopy system to perform scanning microscopy and obtain emission spectra using two photon excited (TPE) luminescence of captured single living cells labeled with core-shell fluorescent semiconductor quantum dots (QDs). The QDs were obtained via colloidal synthesis in aqueous medium with an adequate physiological resulting pH. Sodium polyphosphate was used as the stabilizing agent. The results obtained show the potential presented by this system as well as by these II-VI fluorescent semiconductor quantum dots to perform spectroscopy in living trapped cells in any neighborhood and dynamically observe the cell chemical reactions in real time. 相似文献
539.
Mapping of spikes, slow waves, and motor tasks in a patient with malformation of cortical development using simultaneous EEG and fMRI 总被引:1,自引:0,他引:1
We report on the simultaneous and continuous acquisition of EEG and functional MRI data in a patient with a left hemiparesis and focal epilepsy secondary to malformation of cortical development in the right hemisphere. EEG-triggered fMRI localization was previously demonstrated in this patient. In the experiments reported here, 322 spikes maximum at electrode C4 and 126 focal slow waves were identified offline. A hierarchy of models was explored in order to assess the relative contributions of each type of EEG event. Modeling the BOLD response to C4 spikes alone showed an area of activation within the large malformation, adjacent to the area of infolding cortex. However, also modeling slow-waves gave rise to a broader and stronger activation, suggesting that the generators overlap. Motor mapping of the right hand showed activation in the left sensorimotor cortex; left-hand tapping led to a more diffuse area of activation, displaced superiorly into the superior frontal gyrus, and a small area of activation within the lesion. In conclusion, continuous EEG-fMRI is useful to compare the functional mapping of epileptiform activity and eloquent cortices in individual patients. 相似文献
540.
We have performed CCSD(T), MP2, and DF-LMP2 calculations of the interaction energy of CO on the MgF(2)(110) surface by applying the method of increments and an embedded cluster model. In addition, we performed periodic HF, B3LYP, and DF-LMP2 calculations and compare them to the cluster results. The incremental CCSD(T) calculations predict an interaction energy of E(int) = -0.37?eV with a C-down orientation of CO above a Mg(2+) ion at the surface with a basis set of VTZ quality. We find that electron correlation constitutes about 50% of the binding energy and a detailed evaluation of the increments shows that the largest contribution to the correlation energy originates from the CO interaction with the closest F ions on the second layer. 相似文献