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排序方式: 共有416条查询结果,搜索用时 18 毫秒
351.
Minna Kortelainen Aku Suhonen Dr. Andrea Hamza Dr. Imre Pápai Dr. Elisa Nauha Dr. Sanna Yliniemelä‐Sipari Prof. Dr. Maija Nissinen Prof. Dr. Petri M. Pihko 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(26):9493-9504
A series of small, unsymmetrical pyridine‐2,6‐dicarboxylamide oligoamide foldamers with varying lengths and substituents at the end groups were synthetized to study their conformational properties and folding patterns. The @‐type folding pattern resembled the oxyanion‐hole motifs of enzymes, but several alternative folding patterns could also be characterized. Computational studies revealed several alternative conformers of nearly equal stability. These folding patterns differed from each other in their intramolecular hydrogen‐bonding patterns and aryl–aryl interactions. In the solid state, the foldamers adopted either the globular @‐type fold or the more extended S‐type conformers, which were very similar to those foldamers obtained computationally. In some cases, the same foldamer molecule could even crystallize into two different folding patterns, thus confirming that the different folding patterns are very close in energy in spite of their completely different shapes. Finally, the best match for the observed NOE interactions in the liquid state was a conformation that matched the computationally characterized helix‐type fold. 相似文献
352.
A series of 1,2,4-oxadiazolymethyl sydnones carrying azido group were synthesized and subjected to react with a variety of alkenic and acetylenic dipolarophilic reagents; N-phenyl maleimide, phenyl vinyl sulfone, and phenyl propiolic acid. All the new products are identified by spectral/physical data including high-resolution mass measurements and X-ray diffraction data. 相似文献
353.
Mohammed F. Hamza Amr Fouda Khalid Z. Elwakeel Yuezhou Wei Eric Guibal Nora A. Hamad 《Molecules (Basel, Switzerland)》2021,26(7)
The development of new materials is needed to address the environmental challenges of wastewater treatment. The phosphorylation of guar gum combined with its association to chitosan allows preparing an efficient sorbent for the removal of U(VI) from slightly acidic solutions. The incorporation of magnetite nanoparticles enhances solid/liquid. Functional groups are characterized by FTIR spectroscopy while textural properties are qualified by N2 adsorption. The optimum pH is close to 4 (deprotonation of amine and phosphonate groups). Uptake kinetics are fast (60 min of contact), fitted by a pseudo-first order rate equation. Maximum sorption capacities are close to 1.28 and 1.16 mmol U g−1 (non-magnetic and magnetic, respectively), while the sorption isotherms are fitted by Langmuir equation. Uranyl desorption (using 0.2 M HCl solutions) is achieved within 20–30 min; the sorbents can be recycled for at least five cycles (5–6% loss in sorption performance, complete desorption). In multi-component solutions, the sorbents show marked preference for U(VI) and Nd(III) over alkali-earth metals and Si(IV). The zone of exclusion method shows that magnetic sorbent has antibacterial effects against both Gram+ and Gram- bacteria, contrary to non-magnetic material (only Gram+ bacteria). The magnetic composite is highly promising as antimicrobial support and for recovery of valuable metals. 相似文献
354.
Hamza Mechchate Imane Es-safi Omkulthom Mohamed Al kamaly Dalila Bousta 《Molecules (Basel, Switzerland)》2021,26(7)
Numerous scientific studies have confirmed the beneficial therapeutic effects of phenolic acids. Among them gentisic acid (GA), a phenolic acid extensively found in many fruit and vegetables has been associated with an enormous confirmed health benefit. The present study aims to evaluate the antidiabetic potential of gentisic acid and highlight its mechanisms of action following in silico and in vitro approaches. The in silico study was intended to predict the interaction of GA with eight different receptors highly involved in the management and complications of diabetes (dipeptidyl-peptidase 4 (DPP4), protein tyrosine phosphatase 1B (PTP1B), free fatty acid receptor 1 (FFAR1), aldose reductase (AldR), glycogen phosphorylase (GP), α-amylase, peroxisome proliferator-activated receptor gamma (PPAR-γ) and α-glucosidase), while the in vitro study studied the potential inhibitory effect of GA against α-amylase and α-glucosidase. The results indicate that GA interacted moderately with most of the receptors and had a moderate inhibitory activity during the in vitro tests. The study therefore encourages further in vivo studies to confirm the given results. 相似文献
355.
Mohamed Bouhrim Salima Boutahiri Loubna Kharchoufa Hamza Mechchate Omkulthom Mohamed Al Kamaly Ali Berraaouan Bruno Eto Abderrahim Ziyyat Hassane Mekhfi Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham 《Molecules (Basel, Switzerland)》2021,26(8)
This study aims to assess the safety of the Opuntia dillenii (Ker-Gawl) haw. seed oil (ODSO) and its effect on the glucose absorption activity of the isolated rat hemidiaphragm. This oil’s safety was studied by exploring its acute (doses 1, 3, 5, and 7 mL/kg) and subacute (doses 1 and 2 mL/kg) toxicities in albino mice and Wistar rats, respectively. The safety of the ODSO was also assessed by studying its effect on the HepG2 cell viability in vitro. The effect of ODSO, or combined with the insulin, on the glucose absorption activity of isolated rat hemidiaphragm was evaluated at the dose 1 g/L in vitro. The results demonstrated the safety of ODSO. Indeed, this study showed that this oil does not produce any mortality or signs of toxicity after the single-dose administration in mice. Additionally, the daily intake of the ODSO during four weeks does not induce a significant variation in the biochemical parameters and body weight of rats compared with the control group. Besides, the cell viability of HepG2 did not change in the presence of ODSO. On the other hand, the ODSO increased the glucose absorption activity of the isolated rat hemidiaphragm, and this activity was significantly enhanced when combined with insulin. This study confirms, on one side, the safety of this oil and its efficacy and, on the other side, encourages its potential use as a complement to treat diabetes. 相似文献
356.
Hamza Zougheib Toufic El Arwadi Abdelaziz Soufyane 《Studies in Applied Mathematics》2023,151(3):1136-1165
This paper aims to analyze the energy decay of the thermoelastic porous system. The dual-phase lag theory is used to model heat transfer. We consider two perspectives: the classical approach and the second spectrum approach. For the classical approach, the well-posedness is obtained via the semigroup theory and the system is exponentially stable under equal wave speed conditions. On the opposite, we show a polynomial decay. On the other hand, the well-posedness of the truncated system is obtained via the Faedo Galerkin method, and the system is exponentially stable without any assumptions on the physical parameters. 相似文献
357.
Abstract Damaging effect of diatomic phosphorus ions implanted into silicon was compared with that of atomic ions in the range between 25 and 300 keV/atom. Dose was around 1014 ions/cm2. Target temperature varied between 77 and 533 K. Below and at 300 K the “damage enhancement factor” defined as ratio of damage produced by equivalnet molecular and atomic ion implantation varied from 1 to 1.6 depending on incident energy. At elevated implantation temperature this factor increased by almost an order of magnitude. In interpretation of experimental results, fluctuations in damage structure inside the volume of collision cascades was proposed. Conclusions are believed to be relevant for other molecular implantation, e.g. for the BF2 +. 相似文献
358.
Constrained optimization is an important research topic that assists in quality planning and decision making. To solve such problems, one of the important aspects is to improve upon any constraint violation, and thus bring infeasible individuals to the feasible region. To achieve this goal, different constraint consensus methods have been introduced, but no single method performs well for all types of problems. Hence, in this research, for solving constrained optimization problems, we introduce different variants of the Differential Evolution algorithm, with multiple constraint consensus methods. The proposed algorithms are tested and analyzed by solving a set of well-known bench mark problems. For further improvements, a local search is applied to the best variant. We have compared our algorithms among themselves, as well as with other state of the art algorithms. Those comparisons show similar, if not better performance, while also using significantly lower computational time. 相似文献
359.
Deuterium content of natural waters has been estimated with a mass spectromete using different methods of reduction of water samples. The optimum conditions for isotopic analysis are found, and the different parameters of the instrument are obtained. The accuracy was within ± 3ppm. 相似文献
360.
JPC – Journal of Planar Chromatography – Modern TLC - Six, sensitive, precise and accurate methods have been developed for the determination of cefditoren pivoxil (CP). The first two... 相似文献