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排序方式: 共有919条查询结果,搜索用时 11 毫秒
61.
Laily Rahmawati Sang Hee Park Dong Seon Kim Hwa Pyoung Lee Nur Aziz Chae Young Lee Seung A Kim Seok Gu Jang Dong Sam Kim Jae Youl Cho 《Molecules (Basel, Switzerland)》2022,27(1)
Prasiola japonica possesses several biological activities. However, reports on the anti-inflammatory activities and molecular mechanisms of its different solvent fractions remain limited. In this study, we investigated the potential anti-inflammatory activities of P. japonica ethanol extract (Pj-EE) and four solvent fractions of Pj-EE made with hexane (Pj-EE-HF), chloroform (Pj-EE-CF), butanol (Pj-EE-BF), or water (Pj-EE-WF) in both in vitro (LPS-induced macrophage-like RAW264.7 cells) and in vivo (carrageenan-induced acute paw edema mouse models) experiments. The most active solvent fraction was selected for further analysis. Various in vitro and in vivo assessments, including nitric oxide (NO), cytokines, luciferase assays, real-time polymerase chain reactions, and immunoblotting analyses were performed to evaluate the underlying mechanisms. In addition, the phytochemical constituents were characterized by Liquid chromatography-tandem mass spectrometry. In in vitro studies, the highest inhibition of NO production was observed in Pj-EE-CF. Further examination revealed that Pj-EE-CF decreased the expression of inflammation-related cytokines in LPS-induced RAW264.7 cells and suppressed subsequent AP-1-luciferase activity by inhibition of phosphorylation events in the AP-1 signaling pathway. Pj-EE-CF treatment also demonstrated the strongest reduction in thickness and volume of carrageenan-induced paw edema, while Pj-EE-BF showed the lowest activity. Furthermore, Pj-EE-CF also reduced gene expression and cytokines production in tissue lysates of carrageenan-induced paw edema. These findings support and validate the evidence that Pj-EE, and especially Pj-EE-CF, could be a good natural source for an anti-inflammatory agent that targets the AP1 pathway. 相似文献
62.
Three natural basaltic samples were collected and used as efficient catalysts for the liquid‐phase synthesis of n‐butyl acetate. The samples were characterized by X‐ray fluorescence analysis (XRF), X‐ray diffraction (XRD), thermogravimetry (TG), differential thermal analysis (DTA), Fourier transform infrared (FT‐IR), scanning electron microscopy (SEM), and N2 sorption. The acidity of the samples was determined using isopropanol dehydration, and the strength of the acid sites was measured using chemisorption of basic probes. The catalytic activity of the samples towards the esterification of acetic acid with n‐butanol was extensively examined. The influence of different parameters, such as the reaction refluxing time, molar ratio, catalyst loading, reusability, and calcination temperature, on the esterification reaction was studied in detail. The results revealed that all samples had high catalytic activity with a selectivity of 100% to n‐butyl acetate formation. In addition, the sample obtained from the top hill of Volcano had the highest activity with a 80% yield of n‐butyl acetate. Moreover, the significant catalytic performances were well correlated with the acidity of the samples and to the reaction rate constants. 相似文献
63.
Shaobin Pan Zhe Zhang Qixiang Feng Jin Zhao Shahid Aziz Liwen Dou Jing Li Luyao Huang Huijiao Yan Xiao Wang Jia Li Daijie Wang 《Journal of separation science》2023,46(10):2300042
Cyperus rotundus L. has been extensively used in ancient medication for the treatment of different disorders worldwide, in which sesquiterpenes are the most representative components. In this study, sesquiterpenes were effectively purified by two-dimensional counter-current chromatography in combination with continuous injection and inner-recycling mode with a solvent system of n-hexane/ethyl acetate/methanol/water (1:0.2:1:0.2, v/v/v/v). For one-dimension separation, continuous injection mode was used with three times injection and the inner-recycling mode was adopted for the separation of two mixtures for two-dimensional separation. Finally, four sesquiterpenoids, including scariodione ( 1 ), cyperenoic acid ( 2 ), scariodione ( 3 ), and α-cyperone ( 4 ), were obtained with purities over 98%. Mass spectrometry and nuclear magnetic resonance were applied to identify their structures. The results from the anti-inflammation effect with zebrafish demonstrated that cyperenoic acid exhibited stronger anti-inflammation activity. Molecular docking results suggested that cyperenoic acid possessed lower binding energies –9.4545 kcal/mol with 1CX2 to form formed hydrogen bond interaction with ARG120. In general, all the obtained findings proved that the strong anti-inflammation capacity of cyperenoic acid can have the potential of being adopted for treating diseases resulting from inflammation. 相似文献
64.
Adachi I Aihara H Arinstein K Asner DM Aushev T Aziz T Bakich AM Barberio E Belous K Bhardwaj V Bhuyan B Bondar A Bračko M Brodzicka J Browder TE Chang P Chen A Chen P Cheon BG Chilikin K Chistov R Cho IS Cho K Choi Y Dalseno J Danilov M Drásal Z Drutskoy A Eidelman S Epifanov D Esen S Fast JE Feindt M Gaur V Gabyshev N Garmash A Goh YM Golob B Hara T Hayasaka K Hayashii H Hoshi Y Hou WS Hsiung YB Hyun HJ Iijima T Ishikawa A Iwabuchi M Iwasaki Y Jaegle I Julius T Kang JH Katayama N Kawasaki T 《Physical review letters》2012,108(3):032001
We report the first observations of the spin-singlet bottomonium states h(b)(1P) and h(b)(2P). The states are produced in the reaction e(+)e(-)→h(b)(nP)π(+)π(-) using a 121.4 fb(-1) data sample collected at energies near the Υ(5S) resonance with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider. We determine M[h(b)(1P)]=(9898.2(-1.0-1.1)(+1.1+1.0)) MeV/c(2) and M[h(b)(2P)]=(10,259.8±0.6(-1.0)(+1.4)) MeV/c(2), which correspond to P-wave hyperfine splittings ΔM(HF)=(+1.7±1.5) and (+0.5(-1.2)(+1.6)) MeV/c(2), respectively. The significances of the h(b)(1P) and h(b)(2P) are 5.5σ and 11.2σ, respectively. We find that the production of the h(b)(1P) and h(b)(2P) is not suppressed relative to the production of the Υ(1S), Υ(2S), and Υ(3S). 相似文献
65.
66.
Undoped and doped ZnO with 1 at.% (atomic percentage) chromium (Cr) was synthesized by RF reactive co-sputtering for oxygen gas sensing applications. The prepared films showed a highly c-oriented phase with a dominant (0 0 2) peak at a Bragg angle of around 34.2°. The operating temperature of the prepared ZnO sensor was around 350 °C and shifted to around 250 °C for the doped ZnO sensor which is lower than that of previously reported work. The sensitivity of the sensor toward oxygen gas was enhanced by doping ZnO with 1 at.% Cr. Good stability and repeatability of the sensor were demonstrated when tested under different concentration of oxygen atmosphere. 相似文献
67.
Zirconacycles 1, obtained from diethyl 1-alkynylphosphonates, insert either acyl chlorides or nitriles to provide, after acidic workup, (E)-3-oxo-1-alkenylphosphonates, 2, in isolated yields of 55-83%. Insertion produces only one regio- and stereoisomer. The reaction is quite general and proceeds well with both aliphatic and aromatic acyl chlorides. Acetonitrile and p-methoxybenzonitrile also inserted efficiently. Insertion of isobutyl chloroformate produced the vinylphosphonocarboxylate, 2c, the first representative of this class of compounds. 相似文献
68.
Multiparticle production data on proton-nucleus collisions have been analyzed taking the number of ‘created’ charged particles
instead of the observed number of shower particles as the variable. The mean normalized multiplicity,R
A
, has been found to be independent of energy in the energy range (7–8000) GeV and its mass number dependence has been obtained.
The modified analysis introduces some more regularities in the experimental results onp-nucleus collisions like the invariance with respect to energy of the relationshipR
A
= α + βN
h
and the KNO-like scaling of the multiplicity distributions of the created charged particles. The functional form of the scaling
function has been calculated. 相似文献
69.
Lamkadem M Schwob I Mimouni J Aziz M Bouali A Rabier J Fontonge R Melhaoui A 《Natural product research》2005,19(6):573-580
Numerous original alkaloids are present in tubers of Arisarum vulgare Targ. a species belonging to the Araceae family known in Morocco for its toxicity. Some previous works deal with the activity of these natural compounds as R-irniine. As the enantioselective total synthesis of irniine has been realised, the R- and S-forms were obtained and this last one could be tested. Thus, a study of the cytotoxicity and the electrophysiological activity of S-irniine was carried out on human MRC-5 fibroblasts. A cytotoxic effect of S-irniine at 40 microg/mL was detected on MRC-5 fibroblasts. An electrophysiological study was also carried out on the MRC-5 cells by using the patch-clamp technique and no effect of this compound at this concentration on the outward potassium current of MRC-5 fibroblasts was observed. Thus, this study showed, as it was for R-irniine, that the cytotoxicity of S-irniine was not explained by an effect on the potassium currents. 相似文献
70.
Abe K Abe K Adachi I Aihara H Akatsu M Anipko D Asano Y Aushev T Aziz T Bahinipati S Bakich AM Banerjee S Bedny I Bitenc U Bizjak I Blyth S Bondar A Bozek A Bracko M Brodzicka J Chang P Chao Y Chen A Chen KF Chen WT Cheon BG Chistov R Choi SK Choi Y Chuvikov A Dalseno J Danilov M Dash M Drutskoy A Eidelman S Eiges V Fang F Fratina S Gabyshev N Garmash A Gershon T Gokhroo G Golob B Haba J Hastings NC Hayasaka K Hayashii H Hazumi M Higuchi T Hinz L Hokuue T Hoshi Y Hou S Hou WS Iijima T Imoto A 《Physical review letters》2005,94(22):221805
We report on the first observation of D0/1(2420)-->D0pi- pi+ and D+/1(2420-->D+ pi- pi+ decays (where the contribution from the dominant known D1-->D*pi decay mode is excluded) in the B- -->D0/1pi-) and (-)B0-->D+/1pi- decays, respectively. The observation is based on 15.2 x 10(7) B(-)B events collected with the Belle detector at the KEKB collider. We also set 90% confidence level upper limits for the branching fractions of the four following decays: B- -->D0/1pi-, D01-->D(*0)pi- pi+, (-)B0-->D+/1pi-, D+/1-->D(*+) pi- pi+, B- -->D(*0)2(2460)pi-, D(*0)2 -->D(*0) pi- pi+, (-)B0-->D(*+)2(2460)pi-, D(*+)2-->D(*+)pi- pi+. 相似文献