N,N′‐Bis(2‐hydroxybenzylidene)pentane‐1,5‐diamine

In the title potential O,N,N′,O′‐tetradentate Schiff base ligand {systematic name: 2,2′‐[pentane‐1,5‐diylbis(nitrilomethylidyne)]diphenol}, C₁₉H₂₂N₂O₂, the mutual orientation of the three planar fragments determines the conformation of the molecule. The dihedral angles between the planes of the two salicylidene groups and the plane of the central extended pentane chain are 78.4 (2) and 62.0 (3)°, and the angle between the terminal ring planes is 55.4 (1)°. Strong intramolecular O—H...N hydrogen bonds close almost‐planar six‐membered rings, and the O—H bonds are elongated as a result of hydrogen‐bond formation.     

Toward a Hybrid-Trefftz element with a hole for elasto-plasticity?

The paper deals with the modelling of riveted assemblies for full-scale complete aircraft crashworthiness. Many comparisons between experiments and FE computations of bird impacts onto aluminium riveted panels have shown that macroscopic plastic strains were not sufficiently developed (and localised) in the riveted shell FE in the impact area. Consequently, FE models never succeed in initialising and propagating the rupture in the sheet metal plates and along rivet rows as shown by experiments, without calibrating the input data (especially the damage and failure properties of the riveted shell FE). To model the assembly correctly, it appears necessary to investigate on FE techniques such as Hybrid-Trefftz finite element method (H-T FEM). Indeed, perforated FE plates developed for elastic problems, based on a Hybrid-Trefftz formulation, have been found in the open literature. Our purpose is to find a way to extend this formulation so that the super-element can be used for crashworthiness. To reach this aim, the main features of an elastic Hybrid-Trefftz plate are presented and are then followed by a discussion on the possible extensions. Finally, the interpolation functions of the element are evaluated numerically.     

Far-infrared absorption of large electron-hole drops in stressed Ge

The far-infrared attenuation spectrum due to a large electron-hole drop in inhomogeneously stressed Ge has been measured and compared to the attenuation by small drops in unstressed Ge. The spectrum is analyzed using the full Mie theory for the absorption due to a large sphere; the experimental results are interpreted as bulk plasma absorption in a drop with pair density considerably lowered by the strain.     

Comparison of selected optical properties of oxyfluoride glass fibers doped with Er3+ and co-doped with Er3+ Yb3+

The method of manufacturing and spectroscopic evaluation of the Er³⁺ ions doped and Er³⁺–Yb³⁺co-doped SiO₂–Al₂O₃–Na₂CO₃–CaO–PbO–PbF₂ oxyfluoride glass fibers is presented in the paper. Both optically active elements erbium and ytterbium were introduced into the batch in the form of fluorides. The X-ray diffraction (XRD) technique was applied at each stage of fibers manufacturing in order to control an amorphous structure of the preforms and fibers. Optical studies of glass preforms and fibers (reflection/transmission, absorption, emission, and excited state absorption (ESA)) were directed to examine their suitability as fiber amplifiers at 1.55 μm band.     

Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications

Targeting cap-dependent translation initiation is one of the experimental approaches that could lead to the development of novel anti-cancer therapies. Synthetic dinucleoside 5′,5′-triphosphates cap analogs are potent antagonists of eukaryotic translation initiation factor 4E (eIF4E) in vitro and could counteract elevated levels of eIF4E in cancer cells; however, transformation of these compounds into therapeutic agents remains challenging – they do not easily penetrate into cells and are susceptible to enzymatic cleavage. Here, we tested the potential of several small molecule ligands – folic acid, biotin, glucose, and cholesterol – to deliver both hydrolyzable and cleavage-resistant cap analogs into cells. A broad structure–activity relationship (SAR) study using model fluorescent probes and cap–ligand conjugates showed that cholesterol greatly facilitates uptake of cap analogs without disturbing the interactions with eIF4E. The most potent cholesterol conjugate identified showed apoptosis-mediated cytotoxicity towards cancer cells.

Ligand assisted cellular delivery of negatively charged dinucleotides, which are potential antagonists of the protooncogenic protein eIF4E.     

Application of click chemistry to the production of DNA microarrays

The copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction was applied as the novel method of DNA immobilization on a modified solid support. The CuAAC click reaction enables the covalent binding of DNA modified with pentynyl groups at its 5'-end to azide-loaded slides. Click microarrays were produced using this approach and successfully employed in biological/model experiments.     

Variation of the α3 electron density in electron - hole droplets at constant stress

It has previously been shown that, in an electron-hole drop (EHD) produced in 〈11〉 -stressed Ge, a large population of electrons can be maintained in the strain-split-off (α₃) electron valleys. The density and binding energy of these EHD are calculated on the assumption that the drops contain a single phase with a fixed ratio of α₃ to α₁ electrons. This ratio can be varied experimentally, and the observed densities as a function of α₃ electron fraction are in good agreement with theory.     

Contour of complete nonuniqueness as a method of structural optimization with stability constraints

This paper develops the concept of a contour of complete nonuniqueness and shows its application to the optimal design (optimal layout) of simple trusses transmitting a concentrated force to a presscribed, arbitrary foundation contour. As an example, a symmetric two-bar truss with compressed bars is considered, and the constraints refer to various kinds of elastic instability of the system.Grant No. 05-12-10.2 of the Polish Academy of Sciences is gratefully acknowledged.     

Evolution of midgap states and residual three dimensionality in La2-xSrxCuO4

We carry out extensive first-principles doping-dependent computations of angle-resolved photoemission (ARPES) intensities in La2-xSrxCuO4 over a wide range of binding energies. Intercell hopping and the associated three dimensionality, which is usually neglected in discussing cuprate physics, is shown to play a key role in shaping the ARPES spectra. Despite the obvious importance of strong coupling effects (e.g., the presence of a lower Hubbard band coexisting with midgap states in the doped insulator), a number of salient features of the experimental ARPES spectra are captured to a surprising extent when kz dispersion is properly included in the analysis.