Separable integral extensions and plus closure

We show that an excellent local domain of characteristic p has a separable big Cohen–Macaulay algebra. In the course of our work we prove that an element which is in the Frobenius closure of an ideal can be forced into the expansion of the ideal to a module-finite separable extension ring. Received: 28 May 1998 / Revised version: 30 November 1998     

Experimental observation of intermittent route to chaos in magnetized filamentary discharge plasma due to the cylindrical plasma bubble

We delineate an experimental observation of the effect of the magnetic field along with mesh grid biasing in the presence of a cylindrical plasma bubble in a filamentary discharge magnetised plasma system. The cylindrical mesh grid of 80% optical transparency has been negatively biased and introduced in the plasma for creating a plasma bubble. Plasma floating potential fluctuations have been taken outside (LP1) and inside (LP2) of the plasma bubble. It has been noticed that as the external magnetic field is increased the oscillation pattern shows intermittent route to chaos as the system evolved from regular type of relaxation oscillations (of larger amplitude) to an irregular type of oscillations (of smaller amplitude) We have used recurrence quantification analysis (RQA) to the observed intermittency to chaos in the plasma. The main measures of RQA are laminarity (LAM) and determinism (DET). The laminarity measure can be associated with the average time between the chaotic burst in the intermittency. It has also been observed that the DET depends on the control parameter and decreases exponentially, features like a dip in skewness and a hump in the kurtosis with the variation of control parameter have been noticed, which are the strong evidence of intermittent behaviour of the system. Further, a numerical model has been developed to the observed experimental analysis of the intermittent route to chaos.     

Rh(iii)-Catalyzed [5 + 1] annulation of 2-alkenylanilides and 2-alkenylphenols with allenyl acetates

Herein, we report a mild and highly regioselective Rh(iii)-catalyzed non-oxidative [5 + 1] vinylic C–H annulation of 2-alkenylanilides with allenyl acetates, which has been elusive so far. The reaction proceeds via vinylic C–H activation, regioselective 2,3-migratory insertion, β-oxy elimination followed by nucleophilic cyclization to get direct access to 1,2-dihydroquinoline derivatives. The strategy was also successfully extended to C–H activation of 2-alkenylphenols for constructing chromene derivatives. In the overall [5 + 1] annulation, the allene serves as a one carbon unit. The acetate group on the allene is found to be crucial both for controlling the regio- and chemoselectivity of the reaction and also for facilitating β-oxy elimination. The methodology was scalable and also further extended towards late stage functionalization of various natural products.

A highly regioselective Rh(iii)-catalyzed non-oxidative [5 + 1] vinylic C–H annulation of 2-alkenylanilides and 2-alkenylphenols with allenyl acetates was described for accessing dihyroquinoline and chromene derivatives.     

Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions

The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts ( 1 – 6 ) which will help us to understand and optimize the approaches of either high selectivity or maximum deuterium incorporation. We have demonstrated that the temperature window for these studied iridium(I) catalysts is surprisingly very broad. This principle was further proven in some HIE reactions on complex drug molecules.     

The Phytochemical Profile and Biological Activity of Malva neglecta Wallr. in Surgically Induced Endometriosis Model in Rats

Leaves and aerial parts of Malva neglecta Wallr. have been traditionally used in Anatolia for the treatment of pain, inflammation, hemorrhoids, renal stones, constipation, and infertility. This study investigated the effects of M. neglecta leaves in a rat endometriosis model. The dried plant material was extracted with n-hexane, ethyl acetate, and methanol, successively. Experimental endometriosis was surgically induced in six-week-old female, non-pregnant, Wistar albino rats by autotransplant of endometrial tissue to the abdominal wall. After twenty-eight days, rats were evaluated for a second laparotomy. Endometrial foci areas were assessed, and intraabdominal adhesions were scored. Rats were divided into five groups as control, n-hexane, ethyl acetate, methanol, and aqueous extracts, as well as reference. At the end of the treatment, all rats were sacrificed and endometriotic foci areas and intraabdominal adhesions were re-evaluated and compared with the previous findings. Moreover, peritoneal fluid was collected to detect tumor necrosis factor- α (TNF-α), vascular endothelial growth factor (VEGF), and interleukin-6 (IL-6) levels, and cDNA synthesis, and a quantitative real-time polymerase chain reaction (PCR) test was done. The phytochemical content of the most active extract was determined using High-Performance Liquid Chromatography (HPLC). Both endometrial volume and adhesion score decreased significantly in the group treated with methanol extract. In addition, significant decreases were observed in TNF-α, VEGF, and IL-6 levels in animals administered methanol extract. HPLC results showed that the activity caused by the methanol extract of M. neglecta was due to the polyphenols. Taken together, these novel findings indicate that M. neglecta may be a promising alternative for the treatment of endometriosis.     

Dissipative particle dynamics for complex geometries using non‐orthogonal transformation

Dissipative particle dynamics (DPD) was applied to fluid flow in irregular geometries using non‐orthogonal transformation, where an irregular domain is transformed into a simple rectangular domain. Transformation for position and velocity was used to relate the physical and computational domains. This approach was described by simulating fluid flow inside a two‐dimensional convergent–divergent nozzle. The nozzle geometry is controlled by the contraction ratio (CR) in the middle of the channel. The range of Reynolds number and CR, in this paper, was Re = 10hbox??200 and CR = 0.8 and 0.6, respectively. The DPD results were validated against in‐house computational fluid dynamic (CFD) finite volume code based on the stream function vorticity approach. The results revealed an excellent agreement between DPD and CFD. The maximum deviation between the DPD and CFD results was within 2%. Local and average coefficients of friction was calculated and it compared well with the CFD results. Copyright © 2011 John Wiley & Sons, Ltd.     

Sorption of anti-infective organic molecules from aqueous solutions onto zirconium phosphate

Amorphous zirconium phosphate (ZP), an inorganic ion exchange material of tetravalent metal acid (tma) salt, is synthesized by the sol-gel method and characterized by elemental analysis (ICP-AES), thermal analysis (TGA, DSC), FT-IR and X-ray diffraction studies. The resistivity of the material to acids, bases and organic solvents is assessed. The sorption behavior of the dyes acriflavin (AF) and brilliant green (BG) toward ZP was studied at 313, 323 and 333 K and the kinetic and thermodynamic parameters evaluated. Adsorption isotherms [Langmuir and Fruendlich], breakthrough capacity and elution behavior of these dyes are also studied. The sorption affinity of dyes towards ZP is BG > AF.     

On Semi-Finite Hexagons of Order (2, <Emphasis Type="Italic">t</Emphasis>) Containing a Subhexagon

The research in this paper was motivated by one of the most important open problems in the theory of generalized polygons, namely the existence problem for semi–finite thick generalized polygons. We show here that no semi–finite generalized hexagon of order (2, t) can have a subhexagon H of order 2. Such a subhexagon is necessarily isomorphic to the split Cayley generalized hexagon H(2) or its point–line dual H ^D (2). In fact, the employed techniques allow us to prove a stronger result. We show that every near hexagon \({\mathcal{S}}\) of order (2, t) which contains a generalized hexagon H of order 2 as an isometrically embedded subgeometry must be finite. Moreover, if \({H \cong H^{D}}\)(2) then \({\mathcal{S}}\) must also be a generalized hexagon, and consequently isomorphic to either H ^D (2) or the dual twisted triality hexagon T(2, 8).     

Rapid analysis of titer,aggregate, and intact mass of antibody therapeutics using automated multi-dimensional liquid chromatography coupled with native mass spectroscopy

Monoclonal antibodies are tetrameric complex proteins, primarily produced using mammalian cell culture. Attributes such as titer, aggregates, and intact mass analysis are monitored during process development/optimization. In the present study, a novel workflow such that the Protein-A affinity chromatography is performed in the first dimension for purification and titer estimation, whereas size exclusion chromatography is employed in the second dimension to characterize size variants using native mass spectrometry. The present workflow offers a significant advantage over the traditionally used standalone Protein-A affinity chromatography followed by size exclusion chromatography analysis in that it can monitor these four attributes in 8 min while requiring a minimal sample size (10–15 μg) and not requiring any manual peak collection. In contrast, the traditional standalone approach requires manual collection of eluted peaks in Protein-A affinity chromatography followed by buffer exchange to a mass-compatible buffer, which can take up to 2–3 h with considerable risk of sample loss, degradation, and induced modifications. As the biopharma industry moves to make analytical testing efficient, we believe that the approach proposed here would be of significant interest due to its ability to monitor multiple process and product quality attributes in a single workflow and via rapid analysis.