Participation of the nucleobases in the regioselective backbone fragmentation of nucleic acids. A molecular dynamics and tandem mass spectrometric investigation on a model dinucleoside phosphotriester

The anions (I–III) obtained from O-methyl 5′-O-(5′-deoxythymidine) 3′-O-(2′,3′-dideoxyuridine) phosphate by the competitive removal of the 3-N-H protons of the nucleobases and of the methyl group from the phosphotriester bond, assume in the gas phase stable conformations as a function of their charge site. The mass-analyzed ion kinetic energy (MIKE) spectra of I and III show that the regioselective backbone cleavage of the internucleotidic linkage is controlled by the 2′-H proton transfer to the nucleobase within the 5′-end nucleoside. Similar pathways are taken by species II when the nucleobase is eliminated as neutral from the 5′-end nucleoside.     

POLYNOMIAL NUMERICAL INDEX FOR SOME COMPLEX VECTOR-VALUED FUNCTION SPACES

We study the relation between the polynomial numerical indicesof a complex vector-valued function space and the ones of itsrange space. It is proved that the spaces C(K, X) and L(µ,X) have the same polynomial numerical index as the complex Banachspace X for every compact Hausdorff space K and every -finitemeasure µ, which does not hold any more in the real case.We give an example of a complex Banach space X such that, forevery k 2, the polynomial numerical index of order k of X isthe greatest possible, namely 1, while the one of X** is theleast possible, namely k^k/(1–k). We also give new examplesof Banach spaces with the polynomial Daugavet property, namelyL(µ, X) when µ is atomless, and C_w(K, X), C_w*(K,X*) when K is perfect.     

Dieudonné rings associated with

We use Dieudonné theory for periodically graded Hopf rings to determine the Dieudonné ring structure of the -graded Morava -theory , with an odd prime, when applied to the -spectrum (and to ). We also expand these results in order to accomodate the case of the full Morava -theory .

     

On the uniqueness and analyticity of solutions in micropolar thermoviscoelasticity

This paper deals with the linear theory of isotropic micropolar thermoviscoelastic materials. When the dissipation is positive definite, we present two uniqueness theorems. The first one requires the extra assumption that some coupling terms vanish; in this case, the instability of solutions is also proved. When the internal energy and the dissipation are both positive definite, we prove the well-posedness of the problem and the analyticity of the solutions. Exponential decay and impossibility of localization are corollaries of the analyticity.     

Bubble dynamics: Long-time behavior and interaction in viscous liquids

A mathematical two-phase model is used to numerically investigate physical and rheological effects on small, individual bubbles in high-viscosity liquids under pressure impact. It is found out that bubbles remain stable over time at high viscosity and surface tension. The steady case is considered and connected to the stability behavior of the bubble. An upper bound for the bubble radius is derived and the new equilibrium state of the bubble can be predicted by means of stability theorems of differential equations. Finally, the interaction of a limited number of well separated bubbles in an Hele-Shaw flow is mathematically analyzed to visualize and physically interpret their trajectories. (© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Ferromagnetic thin multi-structures

In this paper, starting from the classical 3D non-convex and nonlocal micromagnetic energy for ferromagnetic materials, we determine, via an asymptotic analysis, the free energy of a multi-structure consisting of a nano-wire in junction with a thin film and of a multi-structure consisting of two joined nano-wires. We assume that the volumes of the two parts composing each multi-structure vanish with the same rate. In the first case, we obtain a 1D limit problem on the nano-wire and a 2D limit problem on the thin film, and the two limit problems are uncoupled. In the second case, we obtain two 1D limit problems coupled by a junction condition on the magnetization. In both cases, the limit problem remains non-convex, but now it becomes completely local.     

Frequency optimization in public transportation systems: Formulation and metaheuristic approach

We study the transit frequency optimization problem, which aims to determine the time interval between subsequent buses for a set of public transportation lines given by their itineraries, i.e., sequences of stops and street sections. The solution should satisfy a given origin–destination demand and a constraint on the available fleet of buses. We propose a new mixed integer linear programming (MILP) formulation for an already existing model, originally formulated as a nonlinear bilevel one. The proposed formulation is able to solve to optimality real small-sized instances of the problem using MILP techniques. For solving larger instances we propose a metaheuristic which accuracy is estimated by comparing against exact results (when possible). Both exact and approximated approaches are tested by using existing cases, including a real one related to a small-city which public transportation system comprises 13 lines. The magnitude of the improvement of that system obtained by applying the proposed methodologies, is comparable with the improvements reported in the literature, related to other real systems. Also, we investigate the applicability of the metaheuristic to a larger-sized real case, comprising more than 130 lines.     

Differentiable Functionals and Smoothed Bootstrap

The differentiability properties of statistical functionals have several interesting applications. We are concerned with two of them. First, we prove a result on asymptotic validity for the so-called smoothed bootstrap (where the artificial samples are drawn from a density estimator instead of being resampled from the original data). Our result can be considered as a smoothed analog of that obtained by Parr (1985, Stat. Probab. Lett., 3, 97-100) for the standard, unsmoothed bootstrap. Second, we establish a result on asymptotic normality for estimators of type generated by a density functional being a density estimator. As an application, a quick and easy proof of the asymptotic normality of , (the plug-in estimator of the integrated squared density ) is given.     

Modelling the landing of a plane in a calculus lab

We exhibit a simple model of a plane landing that involves only basic concepts of differential calculus, so it is suitable for a first-year calculus lab. We use the computer algebra system Maxima and the interactive geometry software GeoGebra to do the computations and graphics.