Equilibrium points and equilibrium sets of some $$\textit{GI}/M/1$$ GI / M / 1 queues

Queueing Systems - Queues can be seen as a service facility where quality of service (QoS) is an important measure for the performance of the system. In many cases, the queue implements the optimal...     

Fracture and Singularities of the Mass-Density Gradient Field

A continuum mechanical theory of fracture without singular fields is proposed. The primary contribution is the rationalization of the structure of a ‘law of motion’ for crack-tips, essentially as a kinematical consequence and involving topological characteristics. Questions of compatibility arising from the kinematics of the model are explored. The thermodynamic driving force for crack-tip motion in solids of arbitrary constitution is a natural consequence of the model. The governing equations represent a new class of pattern-forming equations.     

Numerical study on flow and heat transfer characteristics of square cylinder with lateral sides extension effect

Journal of Thermal Analysis and Calorimetry - The present study analyses the effect of triangular and circular extensions on lateral sides of square cylinder in a confined domain. Two-dimensional...     

Cu–Cl Thermochemical Water Splitting Cycle: Probing Temperature-Dependent CuCl2 Hydrolysis and Thermolysis Reaction Using In Situ XAS

Journal of Thermal Analysis and Calorimetry - Recently, we reported detailed investigations on a hydrolysis step of Cu–Cl thermochemical cycle (Singh et al. in Int J Energy Res...     

COVID-19: inflammatory responses,structure-based drug design and potential therapeutics

Molecular Diversity - The COVID-19 pandemic caused by SARS-CoV-2 is responsible for the global health emergency. Here, we explore the diverse mechanisms of SARS-CoV-induced inflammation. We presume...     

Effect of varying biogas mass flow rate on performance and emission characteristics of a diesel engine fuelled with blends of n-butanol and diesel

Journal of Thermal Analysis and Calorimetry - Dwindling petroleum products and environment degradation, owing to the gases from the exhaust tailpipe of compression ignition engines, have obligated...     

Cloning, Sequencing, and Expression of Nitrile Hydratase Gene of Mutant 4D Strain of Rhodococcus rhodochrous PA 34 in E. coli

The NHase encoding gene of mutant 4D was isolated by PCR amplification. The NHase gene of mutant 4D was successfully cloned and expressed in Escherichia coli by using Ek/LIC Duet cloning kits (Novagen). For the active expression of the NHase gene, the co-expression of small cobalt transporter gene (P-protein gene) has also been co-expressed with NHase gene E. coli. The nucleotide sequence of this NHase gene revealed high homology with the H-NHase of Rhodococcus rhodochrous J1. The recombinant E. coli cells showed higher NHase activity (5.9?U/mg?dcw) as compared to the wild (4.1?U/mg?dcw) whereas it is less than the mutant strain (8.4?U/mg?dcw). Addition of cobalt ion in Luria?CBertani medium is needed up to a very small concentration (0.4?mM) for NHase activity. The recombinant E. coli exhibited maximum NHase activity at 6?h of incubation and was purified with a yield of 56?% with specific activity of 37.1?U/mg protein.     

A Comparative Synthetic Strategy Perspective on α-Amino Acid- and Non-Amino Acid-Derived Synthons towards Total Syntheses of Selected Natural Macrolides

Macrocyclic alkaloids (macrolides) and cyclopeptides have an immense range of applications in drug discovery research because of their natural abundance and potential biological and physicochemical properties. Presently, more than 100 approved drugs or clinical drug candidates contain macrocyclic scaffolds as the biologically active component. This review provides an interesting perspective about the use of amino acid-derived chiral pools versus other methods derived from miscellaneous synthons towards the total synthesis of non-peptidic macrolides. The synthetic routes and the key strategies involved in the total syntheses of ten natural macrolides have been discussed. Both the amino acid-derived and non-amino acid-derived synthetic routes have been illustrated to present a comparative study between the two approaches.     

Quantification of doses and health risks to organs and tissues corresponding to different age groups due to radon in water

Journal of Radioanalytical and Nuclear Chemistry - This paper quantifies the inhalation and ingestion doses to different organs and tissues due to radon dissolved in drinking water. For this a...