排序方式: 共有27条查询结果,搜索用时 281 毫秒
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Pukin AV Florack DE Brochu D van Lagen B Visser GM Wennekes T Gilbert M Zuilhof H 《Organic & biomolecular chemistry》2011,9(16):5809-5815
Biotinylated analogues of gangliosides GM2, GM1, GD1a and GalNAc-GD1a were synthesized in high yields using glycosyltransferases from Campylobacter jejuni. The presence of a biotin moiety in the aglycone part of these mimics allows for attachment of these materials onto various streptavidin-coated surfaces. Analysis of the interaction of biotin-appended GM1 with the B subunit of Escherichia coli heat-labile enterotoxin performed in a modified ELISA procedure shows the potential of this compound to replace the natural GM1 in toxin detection. 相似文献
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Bakavets Aliaksei Aniskevich Yauhen Ragoisha Genady Mazanik Alexander Tsyntsaru Natalia Cesiulis Henrikas Streltsov Eugene 《Journal of Solid State Electrochemistry》2021,25(12):2807-2819
Journal of Solid State Electrochemistry - Selective electrochemical transformations of bismuth interlayers in (Bi2)m(Bi2Te3)n superlattices can be of interest as a means of thermoelectric materials... 相似文献
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We report on the first computer simulation studies of the percolation transition of water at the surface of the DNA double helix. With increased hydration, the ensemble of small clusters merges into a spanning water network via a quasi-two-dimensional percolation transition. This transition occurs strikingly close to the hydration level where the B form of DNA becomes stable in experiment. Formation of spanning water networks results in sigmoidlike acceleration of long-range ion transport in good agreement with experiment. 相似文献
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Zaitsau DH Kabo GJ Strechan AA Paulechka YU Tschersich A Verevkin SP Heintz A 《The journal of physical chemistry. A》2006,110(22):7303-7306
Vapor pressures for a series of 1-n-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (alkyl = ethyl, butyl, hexyl, and octyl) ionic liquids (ILs) were measured by the integral effusion Knudsen method. Thermodynamic parameters of vaporization for ILs were calculated from these data. The absence of decomposition of ILs during the vaporization process was proved by IR spectroscopy. Enthalpies of vaporization of ILs were correlated with molar volumes and surface tensions of the compounds. 相似文献
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Ou Fu Dr. Aliaksei V. Pukin H. C. Quarles van Ufford Dr. Johan Kemmink Dr. Nico J. de Mol Prof. Dr. Roland J. Pieters 《ChemistryOpen》2015,4(4):463-470
The bacterial adhesion lectin LecA is an attractive target for interference with the infectivity of its producer P. aeruginosa. Divalent ligands with two terminal galactoside moieties connected by an alternating glucose-triazole spacer were previously shown to be very potent inhibitors. In this study, we chose to prepare a series of derivatives with various new substituents in the spacer in hopes of further enhancing the LecA inhibitory potency of the molecules. Based on the binding mode, modifications were made to the spacer to enable additional spacer–protein interactions. The introduction of positively charged, negatively charged, and also lipophilic functional groups was successful. The compounds were good LecA ligands, but no improved binding was seen, even though altered thermodynamic parameters were observed by isothermal titration calorimetry (ITC). 相似文献
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Oleinikova A Brovchenko I Smolin N Krukau A Geiger A Winter R 《Physical review letters》2005,95(24):247802
The formation of a spanning hydrogen-bonded network of hydration water is found to occur via a 2D percolation transition in various systems: smooth hydrophilic surfaces, the surface of a single protein molecule, protein powder, and diluted peptide solution. The average number of water-water hydrogen bonds at the percolation threshold varies from 2.0 to 2.3, depending on temperature, system size, and surface properties. Calculation of nH allows an easy estimation of the percolation threshold of hydration water in various systems, including biomolecules. 相似文献
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Brovchenko I Krukau A Oleinikova A Mazur AK 《Journal of the American Chemical Society》2008,130(1):121-131
The dynamics of ions and water at the surface of DNA are studied by computer simulations in a wide range of hydrations involving the zone of low-hydration polymorphism in DNA. The long-range mobility of ions exhibits a stepwise increase at three distinct hydration levels. The first of them is close to the midpoint of the water percolation transition as well as the midpoint of the transition between A- and B-DNA forms. It coincides with the onset of the dissociation of ion pairs on the DNA surface probably caused by the increase in the water dielectric permittivity due to the appearance of the spanning hydrogen-bonding network. The other two steps are attributed to the formation of percolating water layers on the surface of DNA accompanied by the progressive escape of ions from the DNA surface. The results agree with earlier experimental data and further corroborate the suggested universal mechanism of the low hydration polymorphism in DNA including intraduplex electrostatic condensation close to the water percolation threshold. 相似文献
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