排序方式: 共有65条查询结果,搜索用时 13 毫秒
41.
Pooja Salve Aruna Vinchurkar Rajesh Raut Ramesh Chondekar Jaya Lakkakula Arpita Roy Md. Jamal Hossain Saad Alghamdi Mazen Almehmadi Osama Abdulaziz Mamdouh Allahyani Anas S. Dablool Md. Moklesur Rahman Sarker Mohd Fahami Nur Azlina 《Molecules (Basel, Switzerland)》2022,27(19)
In the current decade, nanoparticles are synthesized using solvents that are environmentally friendly. A number of nanoparticles have been synthesized at room temperature using water as a solvent, such as gold (Au) and silver (Ag) nanoparticles. As part of nanotechnology, nanoparticles are synthesized through biological processes. Biological methods are the preferred method for the synthesis of inorganic nanoparticles (AgNPs) as a result of their simple and non-hazardous nature. Nanoparticles of silver are used in a variety of applications, including catalysts, spectrally selective coatings for solar absorption, optical objectives, pharmaceutical constituents, and chemical and biological sensing. Antimicrobial agents are among the top uses of silver nanoparticles. In the current study, silver nanoparticles were biologically manufactured through Madhuca longifolia, and their antibacterial activity against pathogenic microorganisms, anticancer, anti-inflammatory, and antioxidant activities were assessed. UV-Vis spectroscopy, XRD (X-ray diffraction), transmission electron microscopy, Zeta Potential, and FTIR were used to characterize silver nanoparticles. The current work describes a cheap and environmentally friendly method to synthesize silver nanoparticles from silver nitrate solution by using plant crude extract as a reducing agent. 相似文献
42.
Tingting Pang Xuanyu Yang Chenyi Yuan Ahmed A. Elzatahry Abdulaziz Alghamdi Xing He Xiaowei Cheng Yonghui Deng 《中国化学快报》2021,32(1):328-338
Incorporation of heteroatoms into the framewo rk of zeolites has become a significant strategy to improve their performance in catalysis and adsorption,because the obtained heteroatom zeolites exhibit quite different properties from the conventional aluminosilicate zeolites in aspects of surface acidity,pore structures,particle size and so on.In this review,the progress on the heteroatom zeolites including their synthesis and application is highlighted.First,the recent advance on the design and synthesis of different heteroatom zeolites is summarized.Special emphasis is placed on the introduction and comparison of three typical methods,including the direct synthesis,post synthesis and improved direct synthesis,for the traditional heteroatom zeolites(such as TS-1,Sn-MFI,Sn-β) and newly-reported heteroatom zeolites(such as W-MFI,Mo-MFI).According to their intrinsic characteristics,the application of heteroatom zeolites in diverse fields,such as production of fine chemicals,air pollution control and biomass conversion is then discussed.Finally,the challenges and perspective on the future development of heteroatom zeolites in low-cost preparation and practical application are proposed. 相似文献
43.
Abdulrahman Alfuraih Khalid Alzimami Andy K. Ma Ali Alghamdi 《Journal of Radioanalytical and Nuclear Chemistry》2013,296(2):1025-1029
Zirconium-89 (89Zr) can be produced in a cyclotron by focusing the proton beam on an yttrium-89 (89Y) foil target. Optimal combination of beam energy and target assembly configuration enables maximum production of 89Zr while minimizing the formation of contaminant nuclides such as 88Zr and 88Y to allow efficient and effective radiopharmaceutical labeling. Accurate modeling of the proton beam and the target is therefore an essential step to assure the best beam and target specification. We used the radiation transport code MCNPX to simulate the transport of protons through the irradiation assembly and the nuclear reaction code TALYS to obtain the production cross sections of various nuclides from proton-89Y reactions. Results from simulating the irradiation of 14 mm diameter targets with aluminum (Al) degrader at 19.8 mA for 1 h suggested that the 0.15 mm thick one would produce 227 MBq while the 0.3 mm thick one would produce 413 MBq of 89Zr with less than 1 % uncertainty. These results show excellent agreement with experimental work in literature. This work provides the basis for further experimental and theoretical assessments of the use of 89Zr as radiopharmaceutical labels. 相似文献
44.
A. Ma J. Awotwi-Pratt A. Alghamdi A. Alfuraih N. M. Spyrou 《Journal of Radioanalytical and Nuclear Chemistry》2008,276(1):119-123
Medical linear accelerators (linacs) are used extensively in modern radiotherapy for their flexibility and versatility. As
the treatment regime moves from low-energy photon beams to high-energy beams, photoneutrons produced in the linac head components
become important. This work used the general purpose Monte Carlo code MCNPX to model the Varian Clinac 2100C linac with a
15 MV photon beam. Simulations are carried out for several field sizes commonly encountered in radiotherapy. Photoneutron
productions in various head components are estimated from the photon fluence and the photoneutron production cross sections.
The results serve as a basis for further studies on using the linac as an alternative neutron source in BNCT and radiation
protection issues arising from photoneutrons in the treatment room. 相似文献
45.
Dr. Jiuxiao Sun B. S. Shengping Zhang Dr. Muneerah Alomar Dr. Areej S. Alqarni M. S. Najla Alotaibi M. S. Badriah Alshahrani Dr. Abeer A. Alghamdi Prof. Zongkui Kou Prof. Wangqiang Shen Prof. Yingquan Chen Prof. Jian Zhang 《Chemical record (New York, N.Y.)》2023,23(6):e202200268
Quantum dots (QDs) with ultrahigh surface-to-volume ratio, abundant edge active sites, forceful quantum confinement and other remarkable physio-chemical properties, have garnered considerable research interest. MXene QDs, as an emerging member of them, have also attracted wide attention in the last six years, and shown great achievements in many fields. This critical review systematically summarizes the various methods for synthesizing MXene QDs. The characteristics and corresponding applications of various MXene QDs are also presented. The advantages and disadvantages of various synthetic methods, and the limitations of corresponding MXene QDs are compared and highlighted. Finally, the challenges and perspectives of synthesizing MXene QDs are proposed. We hope this review will enlighten researchers to the fabrication of more advancing and promising MXene-based QDs with proprietary properties in diverse applications. 相似文献
46.
Atiah H. Almalki Ibrahim A. Naguib Fahad S. Alshehri Badrah S. Alghamdi Hashem O. Alsaab Yusuf S. Althobaiti Sameer Alshehri Fatma F. Abdallah 《Molecules (Basel, Switzerland)》2021,26(18)
The assessment of greenness of analytical protocols is of great importance now to preserve the environment. Some studies have analyzed either only the neurotransmitters, dopamine, serotonin, glutamate, and gamma-aminobutyric acid (GABA), together or with other neurotransmitters and biomarkers. However, these methods have not been investigated for their greenness and were not compared with each other to find the optimum one. Therefore, this study aims to compare seven published chromatographic methods that analyzed the four neurotransmitters and their mixtures using the National Environmental Method Index, Analytical Eco-Scale Assessment (ESA), and Green Analytical Procedure Index (GAPI). As these methods cover both qualitative and quantitative aspects, they offer better transparency. Overall, GAPI showed maximum greenness throughout the analysis. Method 6 was proven to be the method of choice for analyzing the mixture, owing to its greenness, according to NEMI, ESA, and GAPI. Additionally, method 6 has a wide scope of application (13 components can be analyzed), high sensitivity (low LOQ values), and fast analysis (low retention times, especially for glutamate and GABA). 相似文献
47.
Zeyad I. Alehaideb Anuradha Venkatraman Mahadev Kokane Syed Ali Mohamed Saranya Rameshbabu Rasha S. Suliman Sahar S. Alghamdi Hamad Al-Eidi Bandar Alghanem Maha-Hamadien Abdulla Sabine Matou-Nasri 《Molecules (Basel, Switzerland)》2022,27(3)
Liver cancer is a leading cause of cancer death globally. Marine mollusc-derived drugs have gained attention as potential natural-based anti-cancer agents to overcome the side effects caused by conventional chemotherapeutic drugs during cancer therapy. Using liquid chromatography-mass spectrometry, the main biomolecules in the purple ink secretion released by the sea hare, named Bursatella leachii (B. leachii), were identified as hectochlorin, malyngamide X, malyngolide S, bursatellin and lyngbyatoxin A. The cytotoxic effects of B. leachii ink concentrate against human hepatocarcinoma (HepG2) cells were determined to be dose- and time-dependent, and further exploration of the underlying mechanisms causing the programmed cell death (apoptosis) were performed. The expression of cleaved-caspase-8 and cleaved-caspase-3, key cysteine-aspartic proteases involved in the initiation and completion of the apoptosis process, appeared after HepG2 cell exposure to the B. leachii ink concentrate. The gene expression levels of pro-apoptotic BAX, TP53 and Cyclin D1 were increased after treatment with the B. leachii ink concentrate. Applying in silico approaches, the high scores predicted that bioactivities for the five compounds were protease and kinase inhibitors. The ADME and cytochrome profiles for the compounds were also predicted. Altogether, the B. leachii ink concentrate has high pro-apoptotic potentials, suggesting it as a promising safe natural product-based drug for the treatment of liver cancer. 相似文献
48.
49.
Ghulam Md. Ashraf Debarati DasGupta Mohammad Zubair Alam Saleh S. Baeesa Badrah S. Alghamdi Firoz Anwar Thamer M. A. Alqurashi Sharaf E. Sharaf Waleed Al Abdulmonem Mohammed A. Alyousef Fahad A. Alhumaydhi Anas Shamsi 《Molecules (Basel, Switzerland)》2022,27(14)
Microtubule affinity regulating kinase 4 (MARK4) regulates the mechanism of microtubules by its ability to phosphorylate the microtubule-associated proteins (MAP’s). MARK4 is known for its major role in tau phosphorylation via phosphorylating Ser262 residue in the KXGS motif, which results in the detachment of tau from microtubule. In lieu of this vital role in tau pathology, a hallmark of Alzheimer’s disease (AD), MARK4 is a druggable target to treat AD and other neurodegenerative disorders (NDs). There is growing evidence that NDs and diabetes are connected with many pieces of literature demonstrating a high risk of developing AD in diabetic patients. Metformin (Mtf) has been a drug in use against type 2 diabetes mellitus (T2DM) for a long time; however, recent studies have established its therapeutic effect in neurodegenerative diseases (NDs), namely AD, Parkinson’s disease (PD) and amnestic mild cognitive impairment. In this study, we have explored the MARK4 inhibitory potential of Mtf, employing in silico and in vitro approaches. Molecular docking demonstrated that Mtf binds to MARK4 with a significant affinity of −6.9 kcal/mol forming interactions with binding pocket’s critical residues. Additionally, molecular dynamics (MD) simulation provided an atomistic insight into the binding of Mtf with MARK4. ATPase assay of MARK4 in the presence of Mtf shows that it inhibits MARK4 with an IC50 = 7.05 µM. The results of the fluorescence binding assay demonstrated significant binding of MARK4 with a binding constant of 0.6 × 106 M−1. The present study provides an additional axis towards the utilization of Mtf as MARK4 inhibitor targeting diabetes with NDs. 相似文献
50.
Haya Hussain Shujaat Ahmad Syed Wadood Ali Shah Mehreen Ghias Abid Ullah Shafiq Ur Rahman Zul Kamal Farman Ali Khan Nasir Mehmood Khan Juma Muhammad Mazen Almehmadi Osama Abdulaziz Saad Alghamdi 《Molecules (Basel, Switzerland)》2021,26(23)
Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their promising in vitro anticholinesterase activities, they were further investigated for in vivo neuroprotective and memory enhancing effects in scopolamine-induced amnesia using elevated plus maze (EPM) and novel object recognition (NOR) behavioral mice models. The effects of the synthesized compounds on the cholinergic system involvement in the brain hippocampus and their binding mode in the active site of cholinesterases were also determined. Compound h2 (p < 0.001) and h3 (p < 0.001) significantly inhibited the cholinesterases and reversed the effects of scopolamine by significantly reducing TLT (p < 0.001) in EPM, while (p < 0.001) increased the time exploring the novel object. The % discrimination index (DI) was significantly increased (p < 0.001) in the novel object recognition test. The mechanism of cholinesterase inhibition was further validated through molecular docking study using MOE software. The results obtained from the in vitro, in vivo and ex vivo studies showed that the synthesized curcumin analogs exhibited significantly higher memory-enhancing potential, and h3 could be an effective neuroprotective agent. However, more study is suggested to explore its exact mechanism of action. 相似文献