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Cover Picture: Molecular Imaging of Biological Samples on Nanophotonic Laser Desorption Ionization Platforms (Angew. Chem. Int. Ed. 14/2016)
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Many challenges of chemoselectivity arise from the requirement to manipulate incompatible functional groups. Synthetic methods that do not rely on protecting groups are of strategic significance to chemical synthesis. Particularly valuable are molecules with reactive functionalities that are kinetically stabilized against inter- or intramolecular reactions with each other. We have developed a simple access to molecules that contain both ketone and N-H aziridine functionalities. These compounds were found to undergo highly selective reduction and carbonyl addition reactions, making them versatile precursors to complex amines. 相似文献
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Gustavsson T Sarkar N Bányász A Markovitsi D Improta R 《Photochemistry and photobiology》2007,83(3):595-599
We report a comparison of the steady-state absorption and fluorescence spectra of three representative uracil derivatives (uracil, thymine and 5-fluorouracil) in alcoholic solutions. The present results are compared with those from our previous experimental and computational studies of the same compounds in water and acetonitrile. The effects of solvent polarity and hydrogen bonding on the spectra are discussed in the light of theoretical predictions. This comparative analysis provides a more complete picture of the solvent effects on the absorption and fluorescence properties of pyrimidine nucleobases, with special emphasis on the mechanism of the excited state deactivation. 相似文献
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Akos Magyar 《Monatshefte für Mathematik》2002,136(4):287-296
Optimal lower bounds are given for the discrepancy of point distributions w.r.t. geodesic balls on spheres and hyperbolic
spaces. The mean discrepancy is estimated below by using a non-commutative version of the Fourier transform method developed
by Beck for Euclidean spaces.
Received March 2, 2000; in revised form February 28, 2002 Published online August 19, 2002 相似文献
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The paper gives lists of all the primitive permutation groupsof squarefree degree. All such groups are either solvable andact on a prime number of points, or are almost simple. Amongthe almost simple examples, the groups of Lie type have rankat most 2, or the point stabilizer is a parabolic subgroup.2000 Mathematics Subject Classification 20B15. 相似文献
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Georgakilas V Voulgaris D Vázquez E Prato M Guldi DM Kukovecz A Kuzmany H 《Journal of the American Chemical Society》2002,124(48):14318-14319
We report a new method for the purification of HiPCO single-wall carbon nanotubes (SWNT), which consists of the following sequence: (a) organic functionalization of the as-produced nanotubes (pristine tubes, p-SWNT), (b) purification of the soluble functionalized nanotubes (f-SWNT), (c) removal of the functional groups and recovery of purified nanotubes (r-SWNT) by thermal treatment at 350 degrees C, followed by annealing to 900 degrees C. Each of these steps contributes to the purification, but only their sequential combination leads to high-purity materials. Organic functionalization makes the SWNT more easy to handle, which results in a better manipulation for potential practical uses. The electronic properties of the purified tubes are investigated via Raman and NIR spectroscopies along with transmission electron microscopy. 相似文献
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Jarod A. Fincher Andrew R. Korte Jacqueline E. Dyer Sridevi Yadavilli Nicholas J. Morris Derek R. Jones Victoria K. Shanmugam Russel K. Pirlo Akos Vertes 《Journal of mass spectrometry : JMS》2020,55(4)
Mass spectrometry imaging (MSI) is used increasingly to simultaneously detect a broad range of biomolecules while mapping their spatial distributions within biological tissue sections. Matrix‐assisted laser desorption ionization (MALDI) is recognized as the method‐of‐choice for MSI applications due in part to its broad molecular coverage. In spite of the remarkable advantages offered by MALDI, imaging of neutral lipids, such as triglycerides (TGs), from tissue has remained a significant challenge due to ion suppression of TGs by phospholipids, e.g. phosphatidylcholines (PCs). To help overcome this limitation, silicon nanopost array (NAPA) substrates were introduced to selectively ionize TGs from biological tissue sections. This matrix‐free laser desorption ionization (LDI) platform was previously shown to provide enhanced ionization of certain lipid classes, such as hexosylceramides (HexCers) and phosphatidylethanolamines (PEs) from mouse brain tissue. In this work, we present NAPA as an MSI platform offering enhanced ionization efficiency for TGs from biological tissues relative to MALDI, allowing it to serve as a complement to MALDI‐MSI. Analysis of a standard lipid mixture containing PC(18:1/18:1) and TG(16:0/16:0/16:0) by LDI from NAPA provided an ~49 and ~227‐fold higher signal for TG(16:0/16:0/16:0) relative to MALDI, when analyzed without and with the addition of a sodium acetate, respectively. In contrast, MALDI provided an ~757 and ~295‐fold higher signal for PC(18:1/18:1) compared with NAPA, without and with additional Na+. Averaged signal intensities for TGs from MSI of mouse lung and human skin tissues exhibited an ~105 and ~49‐fold increase, respectively, with LDI from NAPA compared with MALDI. With respect to PCs, MALDI provided an ~2 and ~19‐fold increase in signal intensity for mouse lung and human skin tissues, respectively, when compared with NAPA. The complementary coverage obtained by the two platforms demonstrates the utility of using both techniques to maximize the information obtained from lipid MS or MSI experiments. 相似文献