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101.
To classify the lattice polytopes with a given -polynomial is an important open problem in Ehrhart theory. A complete classification of the Gorenstein simplices whose normalized volumes are prime integers is known. In particular, their -polynomials are of the form , where and are positive integers. In the present paper, a complete classification of the Gorenstein simplices with the above -polynomials will be performed, when is either or , where and are prime integers with . Moreover, we consider the number of Gorenstein simplices, up to unimodular equivalence, with the expected -polynomial. 相似文献
102.
Akiyoshi Wada 《Molecular physics》2013,111(5):409-416
The titration curve of poly-L-glutamic acid was studied in connection with the helix-coil transformation. In aqueous solution the transformation has its origin in the ionization of the polar group COOH in the side chain. Conversely the ionization and the titration curve of this molecule are affected by the change of the electrostatic interaction produced by its transformation. It is shown in this report that the experimental result, the titration curve and its modified plot, can be divided into three sections, that is, the ionization of the perfect helix, the region of the helix-coil transformation, and the ionization of the perfect coil. 相似文献
103.
Akiyoshi Hirayama Eitaro Nakashima Masahiro Sugimoto Shin-ichi Akiyama Waichi Sato Shoichi Maruyama Seiichi Matsuo Masaru Tomita Yukio Yuzawa Tomoyoshi Soga 《Analytical and bioanalytical chemistry》2012,404(10):3101-3109
Capillary electrophoresis coupled with time-of-flight mass spectrometry was used to explore new serum biomarkers with high sensitivity and specificity for diabetic nephropathy (DN) diagnosis, through comprehensive analysis of serum metabolites with 78 diabetic patients. Multivariate analyses were used for identification of marker candidates and development of discriminative models. Of the 289 profiled metabolites, orthogonal partial least-squares discriminant analysis identified 19 metabolites that could distinguish between DN with macroalbuminuria and diabetic patients without albuminuria. These identified metabolites included creatinine, aspartic acid, γ-butyrobetaine, citrulline, symmetric dimethylarginine (SDMA), kynurenine, azelaic acid, and galactaric acid. Significant correlations between all these metabolites and urinary albumin-to-creatinine ratios (p?<?0.009, Spearman’s rank test) were observed. When five metabolites (including γ-butyrobetaine, SDMA, azelaic acid and two unknowns) were selected from 19 metabolites and applied for multiple logistic regression model, AUC value for diagnosing DN was 0.927 using the whole dataset, and 0.880 in a cross-validation test. In addition, when four known metabolites (aspartic acid, SDMA, azelaic acid and galactaric acid) were applied, the resulting AUC was still high at 0.844 with the whole dataset and 0.792 with cross-validation. Combination of serum metabolomics with multivariate analyses enabled accurate discrimination of DN patients. The results suggest that capillary electrophoresis-mass spectrometry based metabolome analysis could be used for DN diagnosis. 相似文献
104.
Tatsuya Yamamoto Kazuyuki Kinoshita Nobuyuki Kosaka Yoshitaka Sato Hiroki Shioura Hiroaki Takeuchi Hirohiko Kimura 《Magnetic resonance imaging》2013,31(8):1271-1277
IntroductionTechnological developments have increased the ease of performing perfusion MRI by arterial spin labeling (ASL) in clinical settings. The objective of this study was to evaluate the effects of radiotherapy on extra-axial brain tumors by using MR perfusion images obtained using the pseudo-continuous arterial spin labeling (pcASL) method.Materials and MethodsSix consecutive patients (nine lesions) with extra-axial brain tumors treated only with radiotherapy were enrolled in this study. MR examinations, including pcASL imaging, were performed before and after radiotherapy. Cerebral blood flow, maximum tumor blood flow (mTBF), tumor volume and the ratio of signal enhancement by contrast material (enhancement ratio) were evaluated in serial examinations during the course of radiotherapy. Both the percentage change in mTBF (mTBF ratio) and the percentage change in volume (volume ratio) were calculated using values obtained before and after radiotherapy. The correlation between the volume ratio and the mTBF ratio was assessed using linear regression analysis and Spearman’s rank correlation coefficient (rs).ResultsA strong correlation was demonstrated between the tumor volume ratio and the mTBF ratio before and after radiotherapy (rs= 0.93, P< .01). However, no significant correlation was identified between changes in enhancement and volume ratio (rs= 0.20) or between changes in enhancement and mTBF ratio (rs= 0.30) before and after radiotherapy.ConclusionThe mTBF measured using pcASL may serve as an additive index for tumor volume when determining tumor response to radiotherapy even in the absence of contrast material. 相似文献
105.
Takumi Okihara Masaki Tsuji Akiyoshi Kawaguchi Ken-Ichi Katayama Hideto Tsuji Suong-Hyu Hyon 《Journal of Macromolecular Science: Physics》2013,52(1-2):119-140
An equimolar mixture of poly(L-lactide) and poly(D-lactide) was crystallized into a stereocomplex whose crystal system is triclinic (P1) with cell dimensions: a = 0.916 nm, b = 0.916 nra, c (chain axis) = 0.870 nm, α = 109.2°, β - 109.2°, and γ = 109.8°. In the unit cell, a poly(L-lactide) segment and a poly (D-lactide) segment are contained as a pair and packed laterally in parallel fashion. The L- and D-poly(lactides) in the complex take a 31 helical conformation, which is a little extended from a 103 helix in the homopolymer crystal with the α-form. Homopolymers are also able to take the 31 helical conformation and form the β-form crystal. The 31 helix in the homopolymer crystal is less stable than the 103 one, and hence the β-form is easily transformed to the α-form by annealing. 相似文献
106.
We present a new numerical model of the thermal force in a plasma, based on the Monte Carlo Binary Collision Model (BCM) [T. Takizuka, H. Abe, J. Comput.Phys. 25 (1977) 205]. This model can be applied for the transport simulation of test ions. The model consists of two steps: (i) choosing a background plasma ion velocity from a distorted Maxwell distribution under the temperature gradient, and (ii) calculating a Coulomb collision between a test particle and the above chosen ion by using the BCM. For the step (i), we developed a velocity sampling method from a distorted Maxwellian, which enables the BCM to bring the thermal force on a test particle in the step (ii).A systematic series of simulations has been performed under various conditions to examine the model. The results of these simulations have been compared with the theoretical values, and it is shown that our model simulates the thermal force correctly for important characteristic features; dependences on the temperature gradient, the test particle velocity, and the background plasma density. 相似文献
107.
Mizuho Fushitani Akitaka Matsuda Akiyoshi Hishikawa 《Journal of Electron Spectroscopy and Related Phenomena》2012,184(11-12):561-568
Photoelectron spectroscopy of isolated atoms and molecules using single-order high-harmonics of Ti:Sapphire laser pulses (800 nm, 12 fs/30 fs) is demonstrated. Dielectric multilayer mirrors, SiC/Mg and Mo/Si, are used to isolate the 27th (42 eV) and 59th (91 eV) order harmonics, respectively. The obtained harmonics are characterized by valence and inner-shell photoelectron spectroscopy of Xe. The applications to two-color two-photon ionization of He and pump-probe spectroscopy of ultrafast photodissociation of Br2, Br2(C1Πu) → Br(2P3/2) + Br(2P3/2), are presented. 相似文献
108.
Sasaki Y Asayama W Niwa T Sawada S Ueda T Taguchi H Akiyoshi K 《Macromolecular bioscience》2011,11(6):814-820
Cell-free protein synthesis is a promising technique for the rapid production of proteins. However, the application of the cell-free systems requires the development of an artificial chaperone that prevents aggregation of the protein and supports its correct folding. Here, nanogel-based artificial chaperones are introduced that improve the folding efficiency of rhodanese produced in cell-free systems. Although rhodanese suffers from rapid aggregation, rhodanese was successfully expressed in the presence of the nanogel and folded to the enzymatically active form after addition of cyclodextrin. To validate the general applicability, the cell-free synthesis of ten water-soluble proteins was examined. It is concluded that the nanogel enables efficient expression of proteins with strong aggregation tendency. 相似文献
109.
110.
Chu MX Miyajima K Takahashi D Arakawa T Sano K Sawada S Kudo H Iwasaki Y Akiyoshi K Mochizuki M Mitsubayashi K 《Talanta》2011,83(3):960-965
A contact lens (CL) biosensor for in situ monitoring of tear glucose was fabricated and tested. Biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer and polydimethyl siloxane (PDMS) were employed as the biosensor material. The biosensor consists of a flexible Pt working electrode and a Ag/AgCl reference/counter electrode, which were formed by micro-electro-mechanical systems (MEMS) technique. The electrode at the sensing region was modified with glucose oxidase (GOD). The CL biosensor showed a good relationship between the output current and glucose concentration in a range of 0.03-5.0 mM, with a correlation coefficient of 0.999. The calibration range covered the reported tear glucose concentrations in normal and diabetic patients. Also, the CL biosensor was applied to a rabbit for the purpose of tear glucose monitoring. The basal tear glucose was estimated to 0.11 mM. Also, the change of tear glucose induced by the change of blood sugar level was assessed by the oral glucose tolerance test. As a result, tear glucose level increased with a delay of 10 min from blood sugar level. The result showed that the CL biosensor is expected to provide further detailed information about the relationship between dynamics of blood glucose and tear glucose. 相似文献