A Highly Sensitive Spectrophotometric Assay of Bleomycins Based on the Fading Reaction of Some Halofluorescein Dyes

In weak acidic medium, anticancer antibiotics bleomycin A5 （BLMA5） and bleomycin A2 （BLMA2） can react with halofluorescein dyes such as erythrosin （Ery）, eosin Y （EY）, eosin B （EB） and rose bengal （RB） by virtue of electrostatic attraction and hydrophobic force to form the ion-association complexes, which can result in the fading reactions of four halofluorescein dyes. The maximum fading wavelengths of these four dyes were located at 527 nm for Ery, 515 nm for EY, 517 nm for EB and 546 nm for RB, respectively. The decrements of absorbance （AA） were directly proportional to the concentrations of bleomycin in a certain range. A new method for the determination of bleomycins anticancer drugs based on fading reactions of halofluorescein dyes has been developed. The method was not only highly sensitive but also simple and rapid. The molar absorptivities （ε） ranged from 1.5 × 10^5 to 7.5 × 10^5 L·mol^-1·cm^-1. It was applied to determination of the bleomycins in human serum, urine and rabbit serum samples. In this work, the spectral properties and the optimum reaction conditions were investigated. The structure of ion-association complexes and the reaction mechanism were discussed.     

Synthesis of polypiperazine-amide thin-film membrane on PPESK hollow fiber UF membrane

A new interfacial polymerization (IP) procedure is developed in order to synthesize polypiperazine-amide thin-film membrane on the inner surface of poly(phthalazinone ether sulfone ketone) (PPESK) hollow fiber ultrafiltration (UF) membrane.A hollow fiber composite membrane with good performance was prepared and studied by FT-IR and scanning electron microscopy.     

Chiral Cu(II) complex catalyzed enantioselective addition of phenylacetylene to N-aryl arylimines

Chiral tridentate N-tosylated aminoimine ligands were used in the Cu(II)-catalyzed enantioselective addition of phenylacetylene to N-aryl arylimines, affording products up to 92% ee.     

Hypervalent Iodine(III) Sulfonate Mediated Synthesis of Imidazo[1,2‐a]pyridines

A direct and efficient method for the conversion of alkyl aryl ketones to imidazo[1,2‐α]pyridines has been developed based on initial formation of α‐organosulfonyloxy ketones and their subsequent cyclocondensation by 2‐aminopyridines in one‐pot conditions.     

反相高效液相色谱法半制备分离[T(4-MOP)PS4]卟啉的研究

本文研究了新水溶性５，１０，１５，２０－四（４－甲氧基－３－磺酸苯基）卟啉［Ｔ（４－ＭＯＰ）ＰＳ４］的反相高效液相色谱（ＨＰＬＣ）分离条件。采用ＳｈｉｍｐａｃｋＰＲＥＰ－ＯＤＳ半制备色谱柱，用含有１０ｍｍｏｌ／Ｌ四乙基碘化铵的乙腈－水（体积比２５：７５）为流动相，流速１８ｍＬ／ｍｉｎ，于４１８ｎｍ波长下检测。［Ｔ（４－ＭＯＰ）ＰＳ４］与合成中生成的杂质组分完全分离。经此制备的卟啉纯度高，已成功地应用于自来水样中微量钴、锌、铜离子的ＨＰＬＣ测定中。     

哺乳期母婴微量元素含量的干预研究

通过对陕西省西安地区营养正常的母婴进行干预试验,研究了在其饮食习惯下,哺乳期母婴体内锌、铁、钙三种必需元素的代谢情况,以及是否需要补充,给予适当的补充是否有害。     

A simple and general method for the synthesis of multicomponent Na2V6O16.3H2O single-crystal nanobelts

Multicomponent Na2V6O16.3H2O (barnesite) single-crystalline nanobelts were synthesized by a direct reaction-crystallization growth of bulk V2O5 and NaF powders under hydrothermal treatment without using any templates or catalysts. This new strategy could be extended to prepare other one-dimensional multicomponent nanomaterials including ammonium, alkali-metal or alkali-earth metal vanadium oxide bronzes and other transition metal oxyfluorides. This is an efficient and mild solution method with clear advantages over the traditional high-temperature approach for the large-scale production of 1D multicomponent nanomaterials. The applicability of this approach toward the preparation of other inorganic systems, such as tungstates and molybdates, will be explored.     

Synthesis of Imidazo[2,1‐a]isoquinolines from α‐Tosyloxyketones and 1‐Aminoisoquinoline in Ionic Liquid Solvent

The room temperature ionic liquid n‐butylpyridinium tetrafluoroborate (BPyBF₄) is used as a ‘green’ recyclable alternative to classical molecular solvents for the cyclocondensation of α‐tosyloxyketones with 1‐aminoisoquinoline to prepare imidazo[2,1‐a]isoquinolines in good yields.