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991.
Essmat M. El-Sheref Mohammed A. I. Elbastawesy Alan B. Brown Ahmed M. Shawky Hesham A. M. Gomaa Stefan Brse Bahaa G. M. Youssif 《Molecules (Basel, Switzerland)》2021,26(22)
A mild and versatile method based on Cu-catalyzed [2+3] cycloaddition (Huisgen-Meldal-Sharpless reaction) was developed to tether 3,3’-((4-(prop-2-yn-1-yloxy)phenyl)methylene)bis(4-hydroxyquinolin-2(1H)-ones) with 4-azido-2-quinolones in good yields. This methodology allowed attaching three quinolone molecules via a triazole linker with the proposed mechanism. The products are interesting precursors for their anti-proliferative activity. Compound 8g was the most active one, achieving IC50 = 1.2 ± 0.2 µM and 1.4 ± 0.2 µM against MCF-7 and Panc-1 cell lines, respectively. Moreover, cell cycle analysis of cells MCF-7 treated with 8g showed cell cycle arrest at the G2/M phase (supported by Caspase-3,8,9, Cytochrome C, BAX, and Bcl-2 studies). Additionally, significant pro-apoptotic activity is indicated by annexin V-FITC staining. 相似文献
992.
The direct boundary element method is an excellent candidate for imposing the normal flux boundary condition in vortex simulation of the three-dimensional Navier–Stokes equations. For internal flows, the Neumann problem governing the velocity potential that imposes the correct normal flux is ill-posed and, in the discrete form, yields a singular matrix. Current approaches for removing the singularity yield unacceptable results for the velocity and its gradients. A new approach is suggested based on the introduction of a pseudo-Lagrange multiplier, which redistributes localized discretization errors—endemic to collocation techniques— over the entire domain surface, and is shown to yield excellent results. Additionally, a regularized integral formulation for the velocity gradients is developed which reduces the order of the integrand singularity from four to two. This new formulation is necessary for the accurate evaluation of vorticity stretch, especially as the evaluation points approach the boundaries. Moreover, to guarantee second-order differentiability of the boundary potential distribution, a piecewise quadratic variation in the potential is assumed over triangular boundary elements. Two independent node-numbering systems are assigned to the potential and normal flux distribu- tions on the boundary to account for the single- and multi-valuedness of these variables, respectively. As a result, higher accuracy as well as significantly reduced memory and computational cost is achieved for the solution of the Neumann problem. © 1997 John Wiley & Sons, Ltd. 相似文献
993.
Salwinder Singh Dhaliwal Vivek Sharma Arvind Kumar Shukla Janpriya Kaur Vibha Verma Prabhjot Singh Harkirat Singh Shams H. Abdel-Hafez Samy Sayed Ahmed Gaber Reham Ali Akbar Hossain 《Molecules (Basel, Switzerland)》2021,26(24)
Biofortification of pulse crops with Zn and Fe is a viable approach to combat their widespread deficiencies in humans. Lentil (Lens culinaris Medik.) is a widely consumed edible crop possessing a high level of Zn and Fe micronutrients. Thus, the present study was conducted to examine the influence of foliar application of Zn and Fe on productivity, concentration, uptake and the economics of lentil cultivation (LL 931). For this, different treatment combinations of ZnSO4·7H2O (0.5%) and FeSO4·7H2O (0.5%), along with the recommended dose of fertilizer (RDF), were applied to the lentil. The results of study reported that the combined foliar application of ZnSO4·7H2O (0.5%) + FeSO4·7H2O (0.5%) at pre-flowering (S1) and pod formation (S2) stages was most effective in enhancing grain and straw yield, Zn and Fe concentration, and uptake. However, the outcome of this treatment was statistically on par with the results obtained under the treatment ZnSO4·7H2O (0.5%) + FeSO4·7H2O (0.5%) at S1 stage. A single spray of ZnSO4·7H2O (0.5%) + FeSO4·7H2O (0.5%) at S1 stage enhanced the grain and straw yield up to 39.6% and 51.8%, respectively. Similarly, Zn and Fe concentrations showed enhancement in grain (10.9% and 20.4%, respectively) and straw (27.5% and 27.6% respectively) of the lentil. The increase in Zn and Fe uptake by grain was 54.8% and 68.0%, respectively, whereas uptake by straw was 93.6% and 93.7%, respectively. Also the benefit:cost was the highest (1.96) with application of ZnSO4·7H2O (0.5%) + FeSO4·7H2O (0.5%) at S1 stage. Conclusively, the combined use of ZnSO4·7H2O (0.5%) + FeSO4·7H2O (0.5%) at S1 stage can contribute significantly towards yield, Zn and Fe concentration, as well as uptake and the economic returns of lentil to remediate the Zn and Fe deficiency. 相似文献
994.
Ishani Chatterjee Mengchu Zhou Abdullah Abusorrah Khaled Sedraoui Ahmed Alabdulwahab 《Entropy (Basel, Switzerland)》2021,23(12)
People nowadays use the internet to project their assessments, impressions, ideas, and observations about various subjects or products on numerous social networking sites. These sites serve as a great source to gather data for data analytics, sentiment analysis, natural language processing, etc. Conventionally, the true sentiment of a customer review matches its corresponding star rating. There are exceptions when the star rating of a review is opposite to its true nature. These are labeled as the outliers in a dataset in this work. The state-of-the-art methods for anomaly detection involve manual searching, predefined rules, or traditional machine learning techniques to detect such instances. This paper conducts a sentiment analysis and outlier detection case study for Amazon customer reviews, and it proposes a statistics-based outlier detection and correction method (SODCM), which helps identify such reviews and rectify their star ratings to enhance the performance of a sentiment analysis algorithm without any data loss. This paper focuses on performing SODCM in datasets containing customer reviews of various products, which are (a) scraped from Amazon.com and (b) publicly available. The paper also studies the dataset and concludes the effect of SODCM on the performance of a sentiment analysis algorithm. The results exhibit that SODCM achieves higher accuracy and recall percentage than other state-of-the-art anomaly detection algorithms. 相似文献
995.
Ahmed M. El-Nahas Essam Hammam El-Zeiny M. Ebeid 《Journal of computational chemistry》1998,19(6):585-592
Semiempirical (MNDO and PM3) molecular orbital calculations have been undertaken to study the structures of the ground and excited states of 2,5-distrylpyrazine dye to assess its activity as a laser dye. In the ground and first excited singlet states, the trans-trans structure of C2h symmetry is the most stable structure in the gas phase and in DMSO, which agrees with the experimental findings. Upon excitation, the flexibility of the molecule decreases, leading to a subsequent decrease in the radiationless deactivation pathway and this increases the fluorescence efficiency of DSP. The absorption, excitation, and emission spectra have been calculated at the MNDO level using the PM3 optimized geometries in DMSO. At this level the agreement between theory and experiment is quite good. An estimated absorption band at 377 nm (expt 380 nm) is assigned to the S0→S1 transition. The excited state absorption band at 457 nm (expt 460 nm) is assigned to the S1→S12 transition. The emission band at 458 nm (expt 460 nm) is assigned to the S′1→S′0 transition. The overlap between the emission and the excited-state absorption spectra is presumably the main reason behind the reduced laser activity of the investigated dye. © 1998 John Wiley & Sons, Inc. J Comput Chem 19: 585–592, 1998 相似文献
996.
Muhammad Zahid Akbar Ali Omar Ishurd Amir Ahmed Zulfiqar Ali ViqarUddin Ahmad Yuanjiang Pan 《Helvetica chimica acta》2002,85(2):689-697
Two new monodesmosidic cycloartane triterpene glycosides, depressosides E and F, and two new flavonol glycosides, depressonol A and B, were isolated from the butanol‐soluble part of the EtOH extract of Corchorus depressus L . The structures of the new compounds were elucidated as (22R,24S)‐22,25‐epoxy‐9,19‐cyclolanostane‐3β,16β,24‐triol 3‐[α‐L ‐rhamnopyranosyl‐(1→4)‐β‐D ‐glucopyranoside] ( 1 ), (22R,24S)‐22,25‐epoxy‐9,19‐cyclolanostane‐3β,16β,24‐triol 3‐[α‐D ‐glucopyranosyl‐(1→3)‐β‐D ‐glucopyranoside] ( 2 ), kaempferol 3‐[β‐D ‐glucopyranosyl‐(1→4)‐β‐D ‐galactopyranoside] 7‐[α‐L ‐arabinofuranoside] ( 4 ), and kaempferol 3‐[β‐D ‐glucopyranosyl‐(1→6)‐β‐D ‐galactopyranoside] 7‐[α‐L ‐arabinofuranoside] ( 5 ) on the basis of chemical evidence and detailed spectroscopic studies. 相似文献
997.
María AngelesGarcía Concepcin Lpez RosaM. Claramunt Ahmed Kenz Marcel Pierrot Jos Elguero 《Helvetica chimica acta》2002,85(9):2763-2776
Two desmotropes, 3‐phenyl‐1H‐pyrazole ( 1a ) and 5‐phenyl‐1H‐pyrazole ( 1b ) have been isolated and the conditions for their interconversion established. The X‐ray structure of 1b has been determined (a=10.862(1), b=5.7620(5), c=12.927(2) Å, β=111.435(2)°, space group P21/c), and both tautomers 1a and 1b were characterized by NMR in the solid state (13C‐ and 15N‐CPMAS). In the case of 3‐phenyl‐1H‐indazole ( 2a ), two concomitant polymorphs have been analyzed by X‐ray crystallography, and their NMR spectral properties were determined. The low‐melting‐point polymorph, at 106.7°, contains three molecules in the asymmetric unit (a=41.086(1), b=7.3860(2), c=23.391(1) Å, β=117.697(1)°, space group C2/c) and the high‐melting‐point one, 115.3°, six molecules (a=13.7818(4), b=13.7976(5), c=18.9445(5) Å, α=94.300(3), β=95.131(3), γ=119.428(3)°, space group P‐1). Here, too, it has been experimentally determined how to transform one form into the other. Density‐functional‐theory calculations at the B3LYP/6‐31G** level have been performed in both examples to rationalize the stability of the different tautomers. 相似文献
998.
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