ChCl: Gly (DESs) Promote Environmentally Benign Synthesis of Xanthene Derivatives and Their Antitubercular Activity

A ChCl: Gly (DESs) promoted environmentally benign method was developed for the first time using the reaction of aryl aldehydes and dimedone to give excellent yields of xanthene analogues. The major application of this present protocol is the use of green solvent, a wide range of substrate, short reaction times, ease of recovery, the recyclability of the catalyst, high reaction yield, and ChCl: Gly as an alternative catalyst and solvent. In addition to this, all the synthesized compounds were evaluated for their in vitro antimycobacterial activity against M. tuberculosis H37Ra (MTB) and M. bovis BCG strains. The compounds 3d, 3e, 3f, and 3j showed significant antitubercular activity against MTB and M. bovis strains with minimum inhibitory concentration (MIC) values of 2.5−15.10 µg/mL and 0.26–14.92 µg/mL, respectively. The compounds 3e, 3f, and 3j were found to be nontoxic against MCF-7, A549, HCT 116, and THP-1 cell lines. All the prepared compounds were confirmed by ¹H NMR and ¹³C NMR analysis.     

Rheological properties of cellulose nanocrystal-embedded polymer composites: a review

Nanotechnology provides useful insights into the behavioural properties of materials from the nanoscale point of view, enabling researchers to develop new materials that were previously inconceivable. Cellulose is an ideal candidate for nanomaterial for nanotechnology because of its nanofibrillar structure, abundance, renewability, biodegradability and eco-friendly nature. Nanocrystalline cellulose materials have become the focus many studies related to these materials and their applications. This review summarises the current knowledge on the field of nanomaterials, focussing mainly on the rheological behaviour of polymer nanocomposites embedded with nanocrystalline cellulose. This review will enable better understanding of the use of nanocrystalline cellulose for the development and applications of cellulose nanocrystal-based nanocomposites.     

Backbending Phenomena in Even–Even $${}^{\boldsymbol{162{-}172}}$$ Hf Isotopes

Physics of Atomic Nuclei - This study probes the backbending phenomena in even–even $${}^{162{-}172}$$ Hf isotopes. Experimental ground-state rotational energies up to $$J^{\pi}=36^{+}$$...     

On the Erdös–Lax inequality concerning polynomials

Let $P(z)$ be a polynomial of degree n and for any complex number α, let $D_{\alpha }P(z):=nP(z)+(\alpha ?z)P^{\prime }(z)$ denote the polar derivative of $P(z)$ with respect to α. In this paper, we present an integral inequality for the polar derivative of a polynomial. Our theorem includes as special cases several interesting generalisations and refinements of Erdöx–Lax theorem.     

Solution of the Ulam stability problem for Euler–Lagrange–Jensen k‐quintic mappings

In this paper, we are introducing pertinent Euler–Lagrange–Jensen type k‐quintic functional equations and investigate the ‘Ulam stability’ of these new k‐quintic functional mappings f:X→Y, where X is a real normed linear space and Y a real complete normed linear space. We also solve the Ulam stability problem for Euler–Lagrange–Jensen alternative k‐quintic mappings. Copyright © 2016 John Wiley & Sons, Ltd.     

Biosynthesis of silver nanoparticles using <Emphasis Type="Italic">Artocarpus elasticus</Emphasis> stem bark extract

Background

Green approach in synthesizing metal nanoparticles has gain new interest from the researchers as metal nanoparticles were widely applied in medical equipment and household products. The use of plants in the synthesis of nanoparticles emerges as a cost effective and eco-friendly approach. A green synthetic route for the production of stable silver nanoparticles (Ag-NPs) by using aqueous silver nitrate as metal precursor and Artocarpus elasticus stem bark extract act both as reductant and stabilizer is being reported for the first time.

Results

The resultant Ag-NPs were characterized by UV–vis spectroscopy, powder X-Ray diffraction, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier-transform infra-red (FT-IR). The morphological study by TEM and SEM shows resultant Ag-NPs in spherical form with an average size of 5.81 ± 3.80, 6.95 ± 5.50, 12.39 ± 9.51, and 19.74 ± 9.70 nm at 3, 6, 24, and 48 h. Powder X-ray diffraction showed that the particles are crystalline in nature, with a face-centered cubic structure. The FT-IR spectrum shows prominent peaks appeared corresponds to different functional groups involved in synthesizing Ag-NPs.

Conclusions

Ag-NPs were synthesized using a simple and biosynthetic method by using methanolic extract of A. elasticus under room temperature, at different reaction time. The diameters of the biosynthesis Ag-NPs depended on the time of reaction. Thus, with the increase of reaction time in the room temperature the size of Ag-NPs increases. From the results obtained in this effort, one can affirm that A. elasticus can play an important role in the bioreduction and stabilization of silver ions to Ag-NPs.

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Graphical abstract: Figure illustrates stabilization of silver nanoparticles after formation by A. elasticus stem bark extract.

     

Nonuniform Multiresolution Analysis on Local Fields of Positive Characteristic

A generalization of Mallat’s classic theory of multiresolution analysis (MRA) on local fields of positive characteristic was considered by Jiang et al. (J Math Anal Appl 294:523–532, 2004). In this paper, we present a notion of nonuniform MRA on local field \(K\) of positive characteristic. The associated subspace \(V_0\) of \(L^2(K)\) has an orthonormal basis, a collection of translates of the scaling function \(\varphi \) of the form \(\{ \varphi (x-\lambda ) \}_{ \lambda \in \Lambda }\) where \(\Lambda = \{ 0,r/N \}+ \mathcal{Z}, \,N \ge 1\) is an integer and \(r\) is an odd integer such that \(r\) and \(N\) are relatively prime and \(\mathcal{Z}=\{u(n): n\in \mathbb {N}_{0}\}\). We obtain the necessary and sufficient condition for the existence of associated wavelets and present an algorithm for the construction of nonuniform MRA on local fields starting from a low-pass filter \(m_{0}\) with appropriate conditions.     

Surface and bulk structural properties of nanostructured porous silicon prepared by electrochemical etching at different etching time

Nanostructured porous silicon (NPSi) is versatile nanomaterials, and attractive area in device application after visible luminescence was observed from NPSi by Canham (1990). NPSi has been prepared by electrochemical techniques with silicon wafer as a based material. The electrolyte solution consists of ethanol and hydrofluoric acid at volume ratio of 1:1. The etching time was varied while other preparation parameters were fixed to produce different porosity of NPSi samples. The structural properties of samples were measured using field emission scanning electron microscope and Raman spectrometer. The surface structural study has shown the surface roughness increase at inertial stage but decrease gradually with longer etching time. However, nanostructured surface was decreased with increasing of etching time. From side view measurement, the nanopillar of NPSi becomes smaller size while increase of etching time. The crystallinity of PSi is observed by Raman scattering varied with different etching time. The photoluminescence measurement will be carried out to study the correlation between optical and structural properties.     

Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity

ABSTRACT: BACKGROUND: Cancer is one of the most dreaded diseases and it is a leading cause of mankind death worldwide. Recent reports documented a remarkable antiproliferative activity of isatin nucleus against various cancer cell lines. The current work describes the antiproliferative activity of Schiff bases of combinatorial mixtures of the isatin derivatives M1-M22 as well as the individual compounds 1-11(A-K) of these combinatorial mixtures. RESULTS: The designed combinatorial library composed from eleven hydrazides A-K and eleven isatin derivatives 1-11 has been synthesized to formally generate 22 mixtures, M1-M22 of 121 Schiff bases, and their antiproliferative activity against K562 chronic myelogenous leukemia cells was evaluated. The indexed method of analysis of the prepared library was applied to elucidate the active components in the tested mixtures M1-M22. The predictions from the crossing procedure was validated through evaluation of the antiproliferative activity of individual compounds 1-11(A-K) of the library. Individual compounds 1-11(A-K) were also evaluated against the non-tumorigenic MCF-12A cell line to investigate their selectivity. A pharmacophore model was developed to further optimize the antiproliferative activity among this series of compounds. CONCLUSIONS: Variable antiproliferative activity was revealed with the investigated mixtures M1-M22 and the individual compounds 1-11(A-K). Most of the tested mixtures and several individual Schiff bases displayed high potency with IC50 values in the low micromolar range. A considerable selectivity of some individual compounds to the tumorigenic K562 cell line compared with the non-tumorigenic MCF-12A cell line was observed as indicated by their selectivity index (SI).     

Part III: Study of Tissue Distribution and Retention

The tissue distribution of colloidal zirconyl phosphate-P₃₂ and its retention following i.m and i.v. injection in mice were studied. About 63 per cent of the i.m. injected P₃₂ activity was retained at the site of injection after 5 days, suggesting the use of the colloid in the local treatment of tumours. The deposition of the colloid in bone and liver after i.v. injection presented zirconyl phosphateP₃₂ as useful in the radiotherapy of bone and liver disease.