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51.
M. Sc. Niklas Felix König Dr. Abdelaziz Al Ouahabi Dr. Salomé Poyer Prof. Laurence Charles Dr. Jean-François Lutz 《Angewandte Chemie (International ed. in English)》2017,56(25):7297-7301
A three-step post-polymerization modification method was developed for the design of digitally encoded poly(phosphodiester)s with controllable side groups. Sequence-defined precursors were synthesized, either manually on polystyrene resins or automatically on controlled pore glass supports, using two phosphoramidite monomers containing either terminal alkynes or triisopropylsilyl (TIPS) protected alkyne side groups. Afterwards, these polymers were modified by stepwise copper-catalyzed azide–alkyne cycloaddition (CuAAC). The terminal alkynes were first reacted with a model azide compound, and after removal of the TIPS groups, the remaining alkynes were reacted with another organic azide. This simple method allows for quantitative side-chain modification, thus opening up interesting avenues for the preparation of a wide variety of digital polymers. 相似文献
52.
Mokhtar Mabrouk Sherin F. Hammad Mohamed A. Abdelaziz Fotouh R. Mansour 《Chemistry Central journal》2018,12(1):143
Ligand exchange method is introduced as an alternative to Job’s and mole ratio methods for studying the stoichiometry of relatively weak metal complexes in solutions. The method involves adding varying amounts of a ligand (L) to an excess constant amount of a colored complex (MX) with appropriate stability and molar absorptivity. The absorbance of each solution is measured at the λmax of the initial complex, MX, and plotted against the concentration of the studied ligand, L. If the newly formed complex ML does not absorb at the λmax of the initial complex, then attenuation of the absorbance of the initial complex on adding varying quantities of the investigational ligand gives an inverse calibration line that intersects with the calibration curve of initial complex at a given point. If a line parallel to the ordinate is drawn from this point to the x-axis, the ratio of the two parts of the x-axis to the left and to the right (α/β) gives the metal to ligand molar ratio in the complex formed, ML. The new method has been applied to the study of the composition of iron (III) complexes with three bisphosphonate drugs: alendronate, etidronate, and ibandronate. The mole ratio was found to be 1:1 with the three investigated bisphosphonates and results were further confirmed by Job’s and mole ratio methods. The ligand exchange method is simpler, quicker, easier to perform and more accurate than Job’s and mole ratio methods for studying weak and relatively weak complexes.
相似文献
53.
α-Halo hydroxamic acids were used in the synthesis of N-methoxyindolinones, symmetric and dissymmetric N-methoxymaleimides in good yields. The hydrolysis of N-methoxymaleimides constitues a new and good route to maleic anhydrides. 相似文献
54.
55.
A. A. Amindzhanov K. A. Manonov N. G. Kabirov Gamal Abdelaziz Hussein Abdelrahman 《Russian Journal of Inorganic Chemistry》2016,61(1):81-85
The complexation of copper(II) with 1-methyl-2-mercaptoimidazole in 7 M HCl was potentiometrically studied. The compositions of complexes were determined, and their stepwise formation constants were calculated. The complexes were shown to become less stable with increasing temperature. The thermodynamic functions of complexation were estimated. The copper complexes were shown to surpass the rhenium complexes in stability. 相似文献
56.
Laurence Oswald Dr. Abdelaziz Al Ouahabi Prof. Dr. Laurence Charles Dr. Jean‐François Lutz 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(10):3462-3469
Soluble polystyrene supports with optimal molecular structures for iterative phosphoramidite chemistry were prepared by atom‐transfer radical polymerization (ATRP) and subsequent chain‐end modification steps. The controlled radical polymerization of styrene was first performed in the presence of an 9‐fluorenylmethoxycarbonyl (Fmoc)‐protected amino‐functional ATRP initiator. Soluble supports of different molecular weight were prepared. Size‐exclusion chromatography and NMR analysis indicated formation of well‐defined polymers with controlled chain lengths and narrow dispersity. After synthesis, the bromo ω end group of the ATRP polymer was removed by dehalogenation in the presence of tributyltin hydride, and the Fmoc protecting group of the α moiety was subsequently cleaved with piperidine. The resulting α‐primary amine was afterwards treated with a linker containing a carboxyl group, a cleavable ester site, and a dimethoxytrityl‐protected hydroxyl group to afford ideal soluble supports for phosphoramidite chemistry. NMR analysis indicated that these chain‐end modifications were quantitative. The supports were tested for the synthesis of a non‐natural sequence‐defined oligophosphates. High‐resolution ESI‐MS analysis of the cleaved oligomers indicated formation of uniform species, and thus confirmed the efficiency of the ATRP‐made soluble polymer supports. In addition, the synthesis of a thymidine‐loaded soluble support was achieved. 相似文献
57.
Sayed E. El-Sayed Neveen A. Abdelaziz Hosam-Eldin Hussein Osman Ghadir S. El-Housseiny Ahmed E. Aleissawy Khaled M. Aboshanab 《Molecules (Basel, Switzerland)》2022,27(1)
Resistance to antifungal agents represents a major clinical challenge, leading to high morbidity and mortality rates, especially in immunocompromised patients. In this study, we screened soil bacterial isolates for the capability of producing metabolites with antifungal activities via the cross-streak and agar cup-plate methods. One isolate, coded S6, showed observable antifungal activity against Candida (C.) albicans ATCC 10231 and Aspergillus (A.) niger clinical isolate. This strain was identified using a combined approach of phenotypic and molecular techniques as Lysinibacillus sp. . The purified metabolite displayed fungicidal activity, reserved its activity in a relatively wide range of temperatures (up to 60 °C) and pH values (6–7.8) and was stable in the presence of various enzymes and detergents. As compared to fluconazole, miconazole and Lamisil, the minimum inhibitory concentration of the metabolite that showed 90% inhibition of the growth (MIC90) was equivalent to that of Lamisil, half of miconazole and one fourth of fluconazole. Using different spectroscopic techniques such as FTIR, UV spectroscopy, 1D NMR and 2D NMR techniques, the purified metabolite was identified as terbinafine, an allylamine antifungal agent. It is deemed necessary to note that this is the first report of terbinafine production by Lysinibacillus sp. MK212927, a fast-growing microbial source, with relatively high yield and that is subject to potential optimization for industrial production capabilities. MK212927相似文献
58.
Mahfouz A. Abdelaziz H. H. Moharram Samy A. Essawy A. A. Mohamed 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):269-273
Abstract Several new pyrrolo[1,2-ylidene ethyl cyanoacetate (lc, d) with each of (2) and (11) afforded the 5-ylidene-2-thiohydantoins (Sa, b), (Wn. b) respectively. Compounds Sn, b react with each of malononitrile and ethyl cyanoacet-ate to give the corresponding pyrroloimidazole derivatives (h,b) and (an, b) respectively. The structure of the isolated products were established by elemental analyse and spectral data studies. 相似文献
59.
In a scale-free network,only a minority of nodes are connected very often,while the majority of nodes are connected rarely. However,what is the ratio of minority nodes to majority nodes resulting from the Matthew effect In this paper,based on a simple preferential random model,the poor-rich demarcation points are found to vary in a limited range,and form a poor-rich demarcation interval that approximates to k/m ∈ [3,4]. As a result,the (cumulative) degree distribution of a scale-free network can be divided into three intervals: the poor interval,the demarcation interval and the rich interval. The inequality of the degree distribution in each interval is measured. Finally,the Matthew effect is applied to the ABC analysis of project management. 相似文献
60.