非经典铂类抗肿瘤药物研究

本文综述了非经典铂类抗肿瘤药物的发展概况,介绍了具有口服活性的铂(Ⅳ)配合物,具有空间位阻的铂(Ⅱ)配合物,反式铂(Ⅱ、Ⅳ)配合物,多核铂(Ⅱ)配合物和含有铂-硫键的铂(Ⅱ)配合物,并总结了这几类新型铂配合物的抗肿瘤机理,克服顺铂的耐药性机理及其临床进展。     

掺氢比例对金属丝网阻抑掺氢甲烷燃烧火焰传播的影响

为进一步揭示金属丝网阻抑掺氢甲烷燃烧火焰传播特征的规律,通过实验研究了掺氢比例对不同孔隙密度金属丝网阻火过程的影响。结果表明：随着掺氢比例的增加,金属丝网的阻火难度加大,金属丝网的阻火效果可由成功转为失败,对火焰传播的影响作用可能从抑制转变为促进;当金属丝网阻火失败时,金属丝网会引起火焰褶皱并导致火焰加速,但郁金香形火焰的首现时间有所延迟;随着掺氢比例的增大,火焰穿过金属丝网后的加速现象更为明显;提高金属丝网孔隙密度可提高金属丝网对掺氢甲烷预混火焰的阻火能力,孔隙密度越大,阻火能力越强;60 mpi以上金属丝网能够有效淬熄掺氢甲烷预混火焰。     

铜(Ⅱ)离子导向的自组装研究

A few copper(Ⅱ) ions or groups have been designed and investigated for metal-assisted self assembly. Reactions of these metal units with a number of linear bridging ligands have led to the production of some dinuclear copper(Ⅱ) complexes and coordination polymers in which metal centers are all five-coordinate in the configuration of a square pyramid or a triangular bipyramid.     

草酸根·(1R, 2R-环己二胺)合铂(Ⅱ)的质谱和热分析研究

铂配合物是目前最为广泛使用的抗肿瘤药物。自１９６５年Ｒｏｓｅｎｂｅｒｇ等人发现顺铂具有强烈抑制大肠杆菌细胞分裂的作用后［１］,对抗癌药物的研究和开发已成为生物无机化学的重要领域之一［２－４］。迄今为止,现已有四个铂配合物获准临床使用,其中之一就是草酸根·（１Ｒ,２Ｒ一环己二胺）合铂（Ⅱ）,它是由四氯合铂酸钾与反式－１, ２环己二胺的光学异构体作用,然后与草酸反应而制得的。为了深入研究该药物的物理性质,我们采用几种质谱方法和热分析仪对该化合物的分解机制和热稳定性进行了研究,探讨了分解的可能途径。１…     

Memory Effect of Metal-Oxide-Silicon Capacitors with Self-Assembly Double-Layer Au Nanocrystals Embedded in Atomic-Layer-Deposited HfO2 Dielectric

We report the chemical self-assembly growth of Au nanocrystals on atomic-layer-deposited HfO2 films aminosilanized by （3-Aminopropyl）-trimethoxysilane aforehand for memory applications. The resulting Au nanocrystals show a density of about 4 × 10^11 cm^-2 and a diameter range of 5-8nm. The metal-oxide-silicon capacitor with double-layer Au nanocrystals embedded in HfO2 dielectric exhibits a large C - V hysteresis window of 11.9 V for ±11 V gate voltage sweeps at 1MHz, a flat-band voltage shift of 1.5 V after the electrical stress under 7 V for 1ms, a leakage current density of 2.9 × 10^-8 A/cm^-2 at 9 V and room temperature. Compared to single-layer Au nanocrystals, the double-layer Au nanocrystals increase the hysteresis window significantly, and the underlying mechanism is thus discussed.     

WO_3纳米棒/石墨烯复合材料的制备及电化学储锂性能

以氯化钨和氧化石墨烯(GO)为原料,乙醇为溶剂,一步合成了WO3纳米棒/石墨烯纳米复合材料(WO3/RGO).将WO3/RGO纳米复合材料用于锂离子电池负极,并通过充放电测试、循环伏安(CV)和电化学阻抗谱(EIS)技术综合考察了该材料的储锂性能.结果显示,在0.1C(1C=638 mA?g-1)倍率下,复合物的首次放电比容量达到761.4 mAh?g-1,100次循环后可逆容量仍保持在635 mAh?g-1,保持率为83.4%.即使在5C倍率下容量仍高达460 mAh?g-1.由此说明,WO3/RGO纳米复合物具有优异的循环稳定性及倍率性能,可望用于高性能锂离子电池.     

新疆与哈萨克斯坦在油气和化工等产业合作前景研究

本文在介绍哈萨克斯坦油气和矿产资源状况基础上．分析了该国的炼油、天然气、石油化工、冶金和化肥筹工业的技术现状，预测了新疆与哈国在上述诸方面进行经济与技术合作的前景与可行性.     

基于数据挖掘技术的股票收益率方向研究

本文依据数据挖掘技术对股票收益率的变化方向进行探究。通过小波多尺度分解,将股票价格转化为不同频率域下的子序列数据、并对其中的高频序列进行降噪。构建极度梯度提升树(XGBoost)、以及其它主流机器学习算法,对沪深300和中证500指数中成分股的涨跌进行了拟合并预测。研究发现XGBoost的平均准确率分别达到了54.69%和55.13%,同时依据预测信号构建的投资策略可产生稳定收益,表明该方法具备较强的预测能力。在此基础上,对机器学习算法存在的“黑箱”问题进行了阐述和研究,对模型选股的逻辑进行了探析:提出一种因子权重的度量方法,研究发现市净率、市盈率、能量潮等指标在模型中是较为重要的判别指标,并通过偏相依关系度量了模型中各因子对于股价涨跌方向的边际影响,得到模型倾向于选择市盈率、市净率较小的股票等一些结论,使算法的逻辑更为清楚。     

咔唑及其衍生物合成方法研究进展

咔唑及其衍生物是一类重要的含氮芳杂环化合物,具有许多独特的理化性质及生物活性,分析、归纳、总结了近5年来发表的文献,选取具有代表性的实例,并按照中间体的不同将合成方法分为四类,分别讨论了咔唑及其衍生物合成方法的进展情况,对咔唑及其衍生物成环的新方法给予重点关注.     

Fiber optical parametric oscillator based on photonic crystal fiber pumped with all-normal-dispersion mode-locked Yb:fiber laser

We demonstrate a cost effective, linearly tunable fiber optical parametric oscillator based on a home-made photonic crystal fiber pumped with a mode-locked ytterbium-doped fiber laser, providing linely tuning ranges from 1018 nm to 1038 nm for the idler wavelength and from 1097 nm to 1117 nm for the signal wavelength by tuning the pump wavelength and the cavity length. In order to obtain the desired fiber with a zero dispersion wavelength around 1060 rim, eight sam- ples of photonic crystal fibers with gradually changed structural parameters are fabricated for the reason that it is difficult to accurately customize the structural dimensions during fabrication. We verify the usability of the fabricated fiber experimen- tally via optical parametric generation and conclude a successful procedure of design, fabirication, and verification. A seed source of home-made all-normal-dispersion mode-locked ytterbium-doped fiber laser with 38.57 ps pulsewidth around the 1064 nm wavelength is used to pump the fiber optical parametric oscillator. The wide picosecond pulse pump laser enables a larger walk-off tolerance between the pump light and the oscillating light as well as a longer photonic crystal fiber of 20 m superior to the femtosecond pulse lasers, resulting in a larger parametric amplification and a lower threshold pump power of 15.8 dBm of the fiber optical parametric oscillator.