HPLC–based methods for the determination of levetiracetam in biological and pharmaceutical samples

Levetiracetam is one of the new generation anti–epileptic agents (also known as anticonvulsants or antiseizure drugs). Following its approval for marketing in 2000, levetiracetam has been widely used in the treatment of epilepsy due to its broad spectrum effects. One of the advantages of this antiseizure drug is its rapid and complete absorption after oral administration. It has also minimal drug–drug and food interactions, and shows more than 95% bioavailability. The determination of levetiracetam in various samples is carried out using several analytical methods including HPLC–based methods. HPLC–based methods are used for different pharmaceutical analyses and play an important role in drug monitoring during patient follow–ups. This review provides a summary of the HPLC–based methods used in the determination and quantification of levetiracetam in biological fluids and pharmaceutical preparations.     

Construction of an Octahydropyrido[3,4-b]carbazole Skeleton

Russian Journal of Organic Chemistry - The octahydropyridocarbazole skeleton is an important key structure for the synthesis of pyridocarbazole alkaloids, including the antineoplastic agent...     

A mixed-method optimisation and simulation framework for supporting logistical decisions during offshore wind farm installations

With a typical investment in excess of £100 million for each project, the installation phase of offshore wind farms (OWFs) is an area where substantial cost-reductions can be achieved; however, to-date there have been relatively few studies exploring this. In this paper, we develop a mixed-method framework which exploits the complementary strengths of two decision-support methods: discrete-event simulation and robust optimisation. The simulation component allows developers to estimate the impact of user-defined asset selections on the likely cost and duration of the full or partial completion of the installation process. The optimisation component provides developers with an installation schedule that is robust to changes in operation durations due to weather uncertainties. The combined framework provides a decision-support tool which enhances the individual capability of both models by feedback channels between the two, and provides a mechanism to address current OWF installation projects. The combined framework, verified and validated by external experts, was applied to an installation case study to illustrate the application of the combined approach. An installation schedule was identified which accounted for seasonal uncertainties and optimised the ordering of activities.     

Picone type formula for half‐linear impulsive differential equations with discontinuous solutions

Picone type formula for half‐linear impulsive differential equations with discontinuous solutions having fixed moments of impulse actions is derived. Employing the formula, Leighton and Sturm–Picone type comparison theorems as well as several oscillation criteria for impulsive differential equations are obtained. Copyright © 2014 John Wiley & Sons, Ltd.