Hydroxy and methoxy substituted N 1,N 4-diarylidene-S-methylthiosemicarbazone iron(III) and nickel(II) complexes

Template reactions of 2,4-dihydroxy-, 2,5-dihydroxy-, 2-hydroxy-3-methoxy- and 2-hydroxy-4-methoxy-benzaldehyde with methoxy- and hydroxy-substituted salicylaldehyde S-methylthiosemicarbazones in the presence of NiCl₂ and FeCl₃ resulted in the corresponding hydroxy- and methoxy-substituted N¹,N⁴-diarylidene-S-methylthiosemi-carbazone complexes. Characterization of the compounds, [Fe(L)Cl] and [Ni(L)], was accomplished by means of elemental analysis, conductivity and magnetic measurements, i.r. and ¹H-n.m.r. spectra. A systematic trend has been observed for the chemical shift values of the aromatic protons in the spectra of complexes.     

Synthesis and proton conductivity studies of polystyrene‐based triazole functional polymer membranes

In this study, poly(vinylbenzylchloride) (PVBC) was produced by free‐radical polymerization of 4‐vinylbenzylchloride, and then it was functionalized with 3‐amino‐1,2,4‐triazole (ATri) and 1H‐1,2,4‐triazole (Tri). The composition of the polymers was verified by elemental analysis, and the structure was characterized by Fourier transform infrared and ¹³C‐nuclear magnetic resonance spectra. PVBC was modified by ATri with 68% and Tri with 50% yield. The polymers were doped with trifluoromethanesulfonic acid (TA) at various molar ratios, X = 0.5, 1, 2, and 3 with respect to aminotriazole and triazole units. Proton transfer from TA to the triazole rings was proved with Fourier transform infrared spectroscopy. Thermogravimetric analysis showed that the samples are thermally stable up to approximately 200 °C. Differential scanning calorimetry results illustrated the homogeneity of the materials. Under anhydrous conditions, PVBCATri3TA and PVBCTri3TA showed highest proton conductivity of 0.086 and 0.042 S/cm, respectively. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010     

An oestrogen-derivative labeled with 99mTc and its radiopharmaceutical potential

An oestrogen derivative 3,17-a-oestradiolyl propyl 1,4,8,11-tetraazacyclotetradecanyl-1-(4-methylbenzoic acid)ester (ESTCPTA) that is 3,17-a-oestradiolyl propinol coupled to 1-(4-methylbenzoic acid)1,4,8,11-tetraazacyclotetradecane (CPTA) was synthesized in five steps. The product was purified by recrystallization in ethyl alcohol, and analysed by NMR and IR spectroscopy. ESTCPTA was labeled with ^99mTc and radio thin layer chromatography (RTLC) and radio-paper electrophoresis were used to determine the radiochemical yields. Specific activity was approximately 23.7 GBq/mmol and the labeling yield was over 95%. The biodistribution studies were performed on female Albino Wistar rats. The rats were sacricified by ether narcotization at certain time intervals and the activity of the organs was counted by a gamma counter. The activity per gram tissue was calculated and time activity curves were generated.     

Evaluation of Pomegranate (Punica Granatum L.) Pulps for the Removal of Copper(II) Ions: Kinetic,Equilibrium, and Desorption Studies

Pomegranate pulp has been used as novel adsorbent for removing Cu(II) ions from aqueous solution. The optimum conditions for removal of Cu(II) ions were found to be pH 5.32, biosorbent dose 0.1 g, contact time 120 minutes, initial concentration 50 mg/L, and temperature 30°C. The kinetic data were well fitted to the pseudo-second-order model. The biosorption process agreed with the Langmuir isotherm model. Maximum monolayer biosorption capacity was 7.30 mg/g. Thermodynamic parameters suggest that the biosorption process is spontaneous and exothermic. Desorption studies were carried out with different desorbing agents.      

Novel anhydrous proton conducting copolymers of 1‐vinyl‐1,2,4‐triazole and diisopropyl‐p‐vinylbenzyl phosphonate

Phosphonic acid functional polymers are currently of interest because of their high proton conductivity in humidified and anhydrous systems. In addition, heterocyclic compounds are used in anhydrous proton conducting polymer membranes. In that study, a new copolymer based on 1‐vinyl‐1,2,4‐triazole (VTri) and diisopropyl‐p‐vinylbenzyl phosphonate (VBP) was synthesized, and their thermal, chemical, and proton conducting properties were investigated. The copolymers were synthesized by free radical copolymerization of the corresponding monomers at several monomer feed ratios to obtain P(VTri‐co‐VBP) copolymers. The copolymer samples were then hydrolyzed to produce poly(vinyl triazole‐co‐vinyl phosphonic acid) copolymers. The composition of the copolymers was determined by elemental analysis. The copolymerization and hydrolysis reactions were verified by Fourier transform infrared spectroscopy and ion exchange capacity measurements. Thermogravimetry analysis indicates that the copolymers are thermally stable up to 300°C. In order to increase the proton conductivity, the copolymers were doped with H₃PO₄ at several stoichometric ratios. The proton conductivity increases with triazole and phosphoric acid content. In the absence of humidity, the copolymer electrolyte, P(VTri‐co‐VBPA)1:0.5 X = 2, showed a proton conductivity of 0.005 S/cm at 150°C. Copyright © 2013 John Wiley & Sons, Ltd.     

PHA-L lectin and carbohydrate relationship: conjugation with CdSe/CdS nanoparticles, radiolabeling and in vitro affinities on MCF-7 cells

This research aims to investigate the interaction between phytohemagglutinin-L (PHA-L) and sialic acid, which is abundant on the breast cancer cell (MCF-7) surface and displays monosaccharide characteristics, by experimental and computational methods. Experimentally, CdSe/CdS nanoparticles (QDs) were synthesized; PHA-L was conjugated with QDs and labeled with ¹²⁵I. Radiolabeling yield was found to be 97 ± 1.2 %. Afterwards, in vitro bioaffinities of radiolabeled PHA-L conjugated QDs have been investigated on MCF-7 cells and it has been observed that the cell incorporation increased with time. The results indicated that ¹²⁵I labeled QD-PHA-L conjugates represent significant affinity on MCF-7 cells. In the second step of the study, the crystal structure of carbohydrate interaction surface of PHA-L was extracted from the crystal structure of PHA-L. The interactions between this surface and sialic acid were calculated by computational tools. These calculations revealed specific interactions between PHA-L and sialic acid. Semi-empirical methods, PM3 and AM1, were used in these calculations. Significant outcomes have been obtained from the experimental and computational studies and these results demonstrated that PHA-L may be an effective agent for imagining MCF-7 cells.     

基于金属复分解闭环反应合成新型杯[4]冠醚衍生物

杯[4]芳烃的上端和下端通过金属复分解闭环反应以较高产率合成一系列新型杯[4]冠醚衍生物(8a-c),目标产物结构经元素分析、IR、MS、1H NMR及13C NMR证实。     

Calculations of Isoelectronic Series of He Using Noninteger n‐Slater Type Orbitals in Single and Double Zeta Approximations

Using integer and noninteger n-Slater type orbitals in single- and double-zeta approximations, the Hartree-Fock-Roothaan calculations were performed for the ground states of first ten cationic members of the isoelectronic series of He atom. All the noninteger parameters and orbital exponents were fully optimized. In the case of noninteger n-Slater type orbitals in double zeta basis sets, the results of calculations obtained are more close to the numerical Hatree-Fock values and the average deviations of our ground state energies do not exceed 2×10^－6 hartrees of their numerical results.     

Surface Characterization and the Gas Response of a Mixed,Fe2O3?Fe2(MoO4)3, Oxide to Low Concentrations of H2S in Air

The preparation and H₂S sensing potential of thick‐films of a mixed oxide, Fe₂O₃? Fe₂(MoO₄)₃, were investigated. A Fourier‐transform infrared (FTIR) study confirmed the existence of sulfur species at the surface after the interaction of H₂S gas with the mixed oxide. The starting material, β‐FeMoO₄, was synthesized by a solvothermal method, followed by supercritical drying. Heat treatment of this material (oxidation) above 500 °C resulted in the formation of Fe₂O₃? Fe₂(MoO₄)₃ mixed oxide, where Fe₂O₃ was a by‐product. An increase in the conductivity of the films in the presence of H₂S gas (concentration range 1–20 ppm in air) was observed with the simultaneous formation of water and sulfide ions at 225 °C. An improvement of the H₂S sensing potential is obtained, using an intermediate short heat treatment at higher temperature (500 °C) in the beginning of recovery (desorption) phase. This intermediate high temperature, used before every expected exposure to H₂S gas, may contribute the formation of an initial surface coverage of O^2?.