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During carbon ion therapy, lots of positron emitters such as 11C, 15O, 11C are generated in irradiated tissues by nuclear reactions, and can be used to track the carbon beam in the tissue by a positron emission tomography (PET) scanner. In this study, an dual-plate in-room PET scanner has been designed and evaluated based on the GATE simulation platform to monitor patient dose in carbon ion therapy. The dual-plate PET is designed to avoid interference with the carbon beamline and with patient positioning. Its performance was compared with that of four-head and full-ring PET scanners. The dual-plate, four-head and full-ring PET scanners consisted of 30, 60, 60 detector modules, respectively, with a 36 cm distance measurements. Each detector module consisted of a between directly opposite detector modules for dose deposition 24~24 array of 2 mm×2 mm×18 mm LYSO pixels coupled to a Hamamatsu H8500 PMT. To estimate the production yield of positron emitters, a 10 cm×15 cm×15 cm cuboid PMMA phantom was irradiated with 172, 200, 250 MeV/u 12C beams. 3D images of the activity distribution measured by the three types of scanner are produced by an iterative reconstruction algorithm. By comparing the longitudinal profile of positron emitters along the carbon beam path, it is indicated that use of the dual-plate PET scanner is feasible for monitoring the dose distribution in carbon ion therapy. 相似文献
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A Penning trap system called Lanzhou Penning Trap(LPT) is now being developed for precise mass measurements at the Institute of Modern Physics(IMP).One of the key components is a 7 T actively shielded superconducting magnet with a clear warm bore of 156 mm.The required field homogeneity is 3 × 10-7 over two 1 cubic centimeter volumes lying 220 mm apart along the magnet axis.We introduce a two-step method which combines linear programming and a nonlinear optimization algorithm for designing the multi-section superconducting magnet.This method is fast and flexible for handling arbitrary shaped homogeneous volumes and coils.With the help of this method an optimal design for the LPT superconducting magnet has been obtained. 相似文献