太赫兹时域光谱的药物多组分同时定量测定

应用太赫兹时域光谱(THz-TDS)技术结合化学计量学方法对多组分药物混合物中药物活性成分(API)和药用辅料的含量进行了定量分析研究。用THz-TDS系统测量了无水茶碱、乳糖一水合物和硬脂酸镁三元药物混合物及对乙酰氨基酚、乳糖一水合物、微晶纤维素和可溶性淀粉四元药物混合物的太赫兹吸收光谱,并采用主成分回归(PCR)和偏最小二乘回归(PLS)两种多元校正方法分别建立了太赫兹吸收谱与多元混合物各组分含量的定量回归模型,同时获得了混合物中药物活性成分和药用辅料的含量。PLS回归取得更好结果,其中三元混合物两组分含量的PLS定量模型校正及预测相关系数R均高于0.98,四元混合物中对乙酰氨基酚、乳糖一水合物、微晶纤维素和可溶性淀粉含量的PLS定量模型校正及预测相关系数R均分别高于0.93,0.98,0.63和0.86。结果表明,THz-TDS技术结合化学计量学方法建立定量分析模型能够实现对多元混合物成分含量的无损非破坏定量分析,在药物分析等领域将有广阔的应用价值。     

影响光纤参量振荡器全光时钟提取性能的因素分析

实验考察了输入光信号调制速率、泵浦功率、偏振态以及光纤参量振荡器（FOPO）环形腔内光纤长度、光偏振旋转等因素对FOPO提取的时钟信号相位抖动和幅度噪声的影响。实验表明,在光时钟信号相位抖动均方值（RMS）为0.025 UI的容限内,基于FOPO的全光时钟提取方案对这些变化因素的承受能力分别为:8.2 kHz的输入信号调制速率变化、5 dB的泵浦光功率变化、20泵浦信号方位角变化、2 mm的腔内光纤长度变化以及14的腔内信号方位角变化。这为进一步提高基于FOPO全光时钟提取性能提供了重要实验依据。     

THz-TDS测试中时域脉冲的本质段及其截取模型

利用太赫兹时域谱仪THz-TDS测试样品并计算太赫兹吸收谱的形态和幅度,是太赫兹定性、定量分析的主要途径。在实验中我们发现,谱的形态和幅度不仅与样品吸收特性有关, 而且与计算中所选取的太赫兹时域脉冲的长度密切相关。太赫兹波在片状样品前后表面的多次反射波是造成这个问题的主要原因。太赫兹时域脉冲分为直接载有样品信息的本质段、低信噪比的噪声段和信息重叠的回波段。通过分析太赫兹脉冲的产生机理及脉冲幅度与衰减过程的关系,给出一个半理论半经验的本质段长度截取模型,由此确定进一步计算太赫兹吸收谱的最佳长度。谷氨酰胺(Gln)、组氨酸(His)和胱氨酸(Cys)三种氨基酸样品的实验表明, 该文截点位置截取方法的计算结果是稳定有效的。     

Study of the structure of borromean nucleus 17Ne

The ¹⁷Ne nucleus is a possible candidate with a two-proton borromean halo structure. Since the theoretical model is difficult to handle the three-body system, it is difficult to determine the two-proton halo structure in ¹⁷Ne. In the present research, we try to study the breakup reaction of ¹⁷Ne. For the Borromean nuclei, one-proton knockout results in an unstable nucleus which is decaying further by proton emission. This process will result in an angular correlation between the direction of the aligned recoiling unstable nucleus and its decay products. The angular correlations can give us information about the configuration of the valence proton in the ¹⁷Ne. Furthermore, theoretical calculations indicate that the momentum distributions of ¹⁶F c.m are sensitive to the structure of the halo in ¹⁷Ne. Thus the measurement of momentum distributions of ¹⁶F c.m may also give us conclusive information on the structure of ¹⁷Ne. The present experiment has been done at IMP in Lanzhou using the radioactive beam ¹⁷Ne at 30.8 MeV/u on a 43mg/cm^{2 12}C target. The data analysis is under procedure and the primary results are provided.     

Quasi-Elastic Scattering of 16C from 12C at 47.5 MeV/Nucleon

Differential cross sections for the quasi-elastic scattering of^16 C at 47.5 MeV/nucleon from ^12 C target are measured.Coupled-channels calculations are carried out and the optical potential parameters are obtained by fitting the experimental angular distribution.     

一种单通道彩色图像加密方法

提出了一种彩色图像的单通道加密方法. 在该方法中,首先采用三色光栅编码原理将一幅彩色图像编码为一幅灰度图像,再利用双随机相位加密技术对其加密,从而实现了彩色图像的单通道加密. 该方法既保证了安全性,同时在加密时仅需要一个相干光源,简化了系统,实用性较强. 模拟实验结果证明了其有效性. 关键词： 彩色图像 单通道加密 三色光栅 双随机相位     

Fourier频率域随机谱隐秘信息加载与增量补偿系统

提出一种基于光学原理的Fourier频率域随机谱隐秘信息加载与增量补偿系统,并给出一种隐秘信息的加载方式,可实现光学图像信息隐藏.宿主图像经过随机相位调制后进行Fourier变换得到频率域的随机谱,在此随机谱上加载隐秘信息,同时,系统对由隐秘信息的加入所产生的影响进行补偿.利用该系统所得到的载体图像未经正确的密钥-随机相位-调制时,隐秘信息将弥散在载体图像的Fourier频率域空间,具有较好的不可检测性.此外,即使攻击者知道隐秘信息的存在甚至知道隐藏方法,但在不知道密钥的情况下,依然无法破解隐秘信息的内容     

通过破裂反应研究轻丰中子核的集团结构

概括介绍了关于轻丰中子同位素链集团结构的理论模型和通过破裂反应研究该结构的实验方法、 实验装置及物理分析。 The theoretical models of the cluster structures of the light neutron rich nuclei as well as the corresponding physical mechanism and experimental approaches by breakup reaction have been introduced, which may serve as references for possible experimental studies of the cluster structure of light neutron rich nuclei.      

An Implantation and Detection System for Spectroscopy of 22,24Si

A new decay detection system with high detection efficiency and low detection threshold has been developed for charged-particle decay studies, including -delayed proton, decay or direct proton emission from proton-rich nuclei. The detection system was tested by using the -delayed proton emitter 24Si and was commissioned in the decay study of 22Si produced by projectile fragmentation at the First Radioactive Ion Beam Line in Lanzhou. Under a continuous-beam mode, the isotopes of interest were implanted into two double-sided silicon strip detectors, where the subsequent decays were measured and correlated to the preceding implantations by using position and time information. The system allows to measure protons with energies down to about 200 keV without obvious background in the proton spectrum. Further application of the detection system can be extended to the measurements of -delayed proton decay and the direct proton emission of other exotic proton-rich nuclei.     

THz时域光谱测试中的散射问题

利用太赫兹时域光谱技术(THz-TDS)提取物质在太赫兹波段的吸收谱是太赫兹应用的一个重要方面。THz-TDS实验系统中的被测样片一般是多种成份的微粒与稀释剂(PE)按一定摩尔浓度混合研磨后压制而成的薄圆片。一般认为,吸收谱中出现的随频率缓慢上升的基线是源于样品颗粒对THz波的散射。该基线对准确获取吸收谱中的特征吸收峰的峰高和峰形信息产生了影响,故为了进一步对吸收谱实现准确的定量分析,应设法移除基线,消除样品颗粒散射对吸收谱的影响,使吸收谱中的特征吸收峰更准确的体现被测物质在太赫兹频段内的吸收特性。对基线产生的原因进行了分析,对近年来出现的散射处理方法进行了综述,为了验证文献中去除散射方法的合理性,选取三种氨基酸进行实验,对比了去除散射影响前后氨基酸的摩尔浓度计算精度,结果表明,去除散射影响后部分氨基酸的摩尔浓度计算精度得到了提高,最后综合实验结果提出了THz吸收谱中去除散射影响需要进一步研究的方向。