基于磁场闪络抑制技术的真空沿面闪络实验研究

为解决脉冲功率系统中击穿电压最低的部分,即真空固体绝缘界面,采用磁场闪络抑制技术提高闪络电压,为研究磁场和沿面闪络电压的关系,针对不同介电常数的样品开展了一系列相关实验。实验结果表明：采用电容器对通电螺线管充电产生的脉冲强磁场稳定可靠,并且当施加在绝缘子表面磁场强度为1.1 T时,PMMA材料的闪络电压可以提高至1.8倍。     

单丝及多丝Z箍缩的X射线背光成像

基于X箍缩软X射线辐射点源对单丝及多丝Z箍缩发展过程进行了背光成像研究,实验平台为清华大学电机系研制的脉冲功率装置PPG-Ⅰ（500 kV/400 kA/100 ns）。成像光路安排为：作为X射线源的X箍缩和作为目标物的单丝或多丝（双丝）Z箍缩分别安装在装置的输出主电极阴阳极之间或回流导电杆处,成像胶片采用高分辨力、高灵敏度的X射线胶片。利用自行设计的电流传感器和罗氏线圈对目标物实际流过的电流进行监测。为了测定目标物金属细丝的质量消融率,设计了m级厚度的阶梯光楔。通过大量成像实验,获取了Z箍缩等离子体融合、先驱等离子体形成及不稳定性发展等过程的相关物理图像以及质量消融率、丝芯膨胀率等重要定量参数。     

基于等阻抗差分段法的变阻抗线电路模拟

新型Z箍缩驱动源系统采用变阻抗线结构形式的径向阻抗变换器进行能量传递和变换,为了获得最大的能量效率,需要应用电路模拟方法研究变阻抗线传递功率的特性。采用了等阻抗差分段法对变阻抗线进行了建模计算,与以往的等长度分段方法比较,在相同的分段数量下,等阻抗差分段法在阻抗变化的连续性上优于等长度分段法。给出了具有指数形式的变阻抗线的算例,分别采用两种分段法进行了计算,对计算结果的比较表明:等阻抗差分段法可以使计算更快地收敛到真实解。     

混合模式直线型变压器驱动源模块

在对Marx发生器和直线型变压器驱动源(LTD)电路拓扑结构及等效参数进行分析对比的基础上,结合两种电路拓扑结构的技术特点,提出了基于Marx基本回路的混合模式LTD模块构想。在混合模式LTD模块中,每个基本回路是一个多级的Marx发生器回路,回路中只有前一级或几级开关需要外部触发,而后级开关工作在自击穿模式。计算分析表明：混合模式LTD模块设计可以有效降低LTD系统对多路同步触发的要求;独立回路式结构可提高整个混合模式LTD模块的可维护性;回路间耦合触发的方式可提高整个混合模式LTD的工作可靠性。最后,还探讨了回路内阻、磁芯损耗及Marx发生器回路中后级自击穿开关抖动对混合模式LTD模块参数设计的影响。     

Synthesis, Structure and H+/K+-ATPase Inhibitory Activity of Novel Triazolyl Substituted Tetrahydrobenzofuran Derivatives via One-pot Three-component Click Reaction

Eleven triazolyl substituted tetrahydrobenzofuran derivatives were synthesized in high yields as novel H⁺/K⁺‐ATPase inhibitor via one‐pot CuI‐catalyzed three‐component click reaction of azide, secondary amine and 3‐bromopropyne under mild conditions in water. Their structures were characterized by NMR, IR, ESI‐MS, elemental analysis and single‐crystal X‐ray diffraction analysis. Most of the target compounds exhibited better H⁺/K⁺‐ATPase inhibitory activity than commercial omeprazole with IC₅₀ values less than 15 µmol·L^?1. The initial structure‐activity analysis suggested that the triazole substituted by cycloalkyl, aromatic ring or O‐containing side‐chain seemed to be beneficial for enhancing the activity.     

Development of an LC/MS/MS method in order to determine arctigenin in rat plasma: its application to a pharmacokinetic study

In this study, a simple and sensitive LC/MS/MS method was developed and validated for the determination of arctigenin in rat plasma. The MS detection was performed using multiple reaction monitoring at the transitions of m/z 373.2 → 137.3 for arctigenin and m/z 187.1 → 131.0 for psoralen (internal standard) with a Turbo IonSpray electrospray in positive mode. The calibration curves fitted a good linear relationship over the concentration range of 0.2–500 ng/mL. It was found that arctigenin is not stable enough at both room temperature and ?80 °C unless mixed with methanol before storage. The validated LC/MS/MS method was successfully applied for the pharmacokinetic study of arctigenin in rats. After intravenous injection of 0.3 mg/kg arctigenin injection to rats, the maximum concentration, half‐life and area under the concentration–time curve were 323 ± 65.2 ng/mL, 0.830 ± 0.166 and 81.0 ± 22.1 h ng/mL, respectively. Copyright © 2013 John Wiley & Sons, Ltd.     

Tupisteroide A–C,three new polyhydroxylated steroidal constituents from the roots of Tupistra chinensis

Three new steroidal compounds with polyhydroxy groups, tupisteroide A–C (1–3), were obtained from the roots of Tupistra chinensis, together with one known compound (4) that was isolated from this plant for the first time. The structures of tupisteroide A–C were determined on the basis of one‐ and two‐dimensional NMR spectroscopy, including ¹H–¹H Correlation Spectroscopy, Heteronuclear Multiple Bond Correlation, and Heteronuclear Single Quantum Coherence experiments. The isolated compounds were evaluated for their cytotoxic activities against A549, HepG2, and CaSki cancer cell lines in vitro. Among them, compounds 1, 2, and 4 did not show significant inhibitory activity, but compound 3 showed cytotoxicity against A549 cancer cell lines with IC₅₀ values of 25.0 μM. Copyright © 2012 John Wiley & Sons, Ltd.     

Facile and efficient synthesis of fluorinated fullerene-fused 1,3-dioxolanes: reaction of C60 with fluorinated aromatic aldehyde mediated by lithium perchlorate

A series of fluorinated fullerene-fused 1,3-dioxolanes have been facilely and efficiently synthesized in the presence of easily available LiClO₄·3H₂O. The influences of the number of fluoro-substituents and their positions linked to the phenyl ring on the isolated yield of fullerene-fused 1,3-dioxolanes have been studied in detail. Based on reaction facts, a possible reaction mechanism for the formation of fluorinated fullerene-fused 1,3-dioxolanes has been proposed. Furthermore, detailed ultraviolet absorption spectra, fluorescence emission spectra, and cyclic voltammogram further explain the optical properties and electronic transmission capabilities of the products.