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Maoji Jiu (MJ) is a kind of medicinal wine that has been widely used by Chinese people for many years to nourish and promote blood circulation. The purpose of this study was to investigate the hematopoietic effect of MJ on the metabolism of blood deficient rats and to explore the underlying hematopoietic regulation mechanisms. Blood deficiency model rats were induced by subcutaneous injection of N-acetylphenylhydrazine (APH) and intraperitoneal injection of cyclophosphamide (CTX). The plasma metabolic fingerprints of blood deficiency model rats with and without MJ treatment were obtained by using metabonomics based on ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC–QTOF/MS). Orthogonal partial least squares-discriminant analysis (OPLS–DA) was used to evaluate the hematopoietic effect of MJ and identify potential biomarkers in the plasma of blood deficiency model rats. The levels of white blood cells (WBC), red blood cells (RBC) and hemoglobin (HGB) and the activity of antioxidant capacity showed a recovery trend to the control group after MJ treatment, while the dose of 10 mL/kg showed the best effect. In this study, thirteen potential biomarkers were identified, which were mainly related to seven metabolic pathways, including linoleic acid metabolism, d-glutamine and d-glutamate metabolism, alanine, aspartate and glutamate metabolism, tryptophan metabolism, pyrimidine metabolism, porphyrin and chlorophyll metabolism and arginine biosynthesis. Metabolomics was applied frequently to reflect the physiological and metabolic state of organisms comprehensively, indicating that the rapid plasma metabonomics may be a potentially powerful tool to reveal the efficacy and enriching blood mechanism of MJ. 相似文献
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20世纪80年代以来,一波超级全球化席卷全球。当今世界进入了百年未有之大变局,全球化陷入困境。应当如何理解当前的全球化困境?百年未有之大变局究竟变在何处?为此,可以从经济学、政治学、社会学与国际关系的综合视角,构建“经济−社会−政治”为一体的、动态演化的框架,以理解当今世界全球化的深层次矛盾。近一波全球化过程中全球经济力量与收入分配格局发生了变化,出现了发达经济体的经济停滞和新兴经济体的赶超,也导致了社会各阶层和不同社会群体的收入和财富差距发生巨变。全球化中全球经济基础的变化,即全球化中的全球经济力量格局变迁与收入分配恶化将对各国的经济和社会基础产生重大影响,进而影响上层建筑:国家的主导思想和意识形态。一个国家在国际关系和经济政策领域主导思想的演变,势必影响其对外战略和政策选择,进而影响本国的经济走向乃至全球化的历史进程。 相似文献
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Zhigang Feng 《Mathematical Methods of Operations Research》2013,77(3):445-457
Overlapping generations models may have a continuum of equilibria. Previous studies have been largely confined to the local analysis that linearizes the model around the steady state. However, what is true of the linearized system only applies for an unknown-sized open neighborhood of the steady state. In this paper I develop a method to diagnose the indeterminacy in overlapping generations models by computing the set of all equilibria. I also provide a procedure to simulate the economy with indeterminate equilibrium. 相似文献
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Ailong Wu Zhigang Zeng 《Communications in Nonlinear Science & Numerical Simulation》2013,18(2):373-385
In this paper, we formulate and investigate a class of memristive recurrent neural networks. Two different types of anti-synchronization algorithms are derived to achieve the exponential anti-synchronization of the coupled systems based on drive–response concept, differential inclusions theory and Lyapunov functional method. The proposed anti-synchronization algorithms are simple and can be easily realized. The analysis in the paper employs results from the theory of differential equations with discontinuous right-hand side as introduced by Filippov. The obtained results extend some previous works on conventional recurrent neural networks. 相似文献