TritonX-100 selective chemosensor based on β-cyclodextrin modified by anthracene derivative

β-Cyclodextrin (CD) modified by 2-(9-anthracenecarboxamido)phenyl group (Ant-CD) was synthesized and their complexation behavior was investigated by UV and fluorescence spectroscopy. Fluorescence intensity of Ant-CD was dramatically enhanced ca. 10-fold by the addition of TritonX-100 (TX-100) in water below the critical micelle concentration. Ant-CD also showed ca. 4-fold fluorescence increasing in the addition of analogous materials, n-octylbenzenesulfonate in water. These results indicate that Ant-CD can act as a highly sensitive and selective chemosensor for TX-100. Ant-CD and TX-100 formed a pseudorotaxane supramolecular complex. This result was supported by ¹H-¹H NOESY NMR measurement.     

Preparation of a cycloheptane ring from a 1,2-diketone with high stereoselectivity

Treatment of 1,6-dialkylhexa-1,5-diene-3,4-diones with bis(iodozincio)methane gave zinc alkoxides of cis-5,6-dialkylcyclohepta-3,7-diene-1,3-diol in good yields at room temperature. The reaction proceeded with high stereospecificity. Bis(iodozincio)methane converted the diketone into the cis-divinylcyclopropane-1,2-diol stereoselectively; this diol transformed into the corresponding cycloheptane derivative stereospecifically via Cope rearrangement.     

Hydrofluoroarylation of alkynes with fluoroarenes

A combination of Ni(cod)(2) and PCyp(3) is found to be an effective catalyst for chemoselective activation of the C-H bond of fluoroarenes over C-F bonds followed by insertion of alkynes to allow direct alkenylation of the electron-deficient arenes. The characteristics of the reactions are: a C-H bond ortho to a fluorine substituent is selectively activated; the reactivity of fluorobenzenes is roughly proportional to the number of fluorine atoms. The reaction conditions tolerate a broad range of both alkynes and fluoroarenes containing both electron-withdrawing and -donating groups, thus allowing efficient synthesis of a variety of substituted ethenes containing a fluoroaryl motif in high regio- and stereoselective manners. Mechanistic studies including both labeling experiments and stoichiometric reactions reveal that oxidative addition of C-H bonds in fluoroarenes to nickel(0) is kinetically highly facile whereas that of C-F bonds is thermodynamically favoured.     

Optimization of simulated moving bed chromatography with fractionation and feedback: Part II. Fractionation of both outlets

A new improvement based on outlet fractionation and feedback has been developed for simulated moving bed (SMB) chromatography. In this contribution, this fractionation and feedback SMB (FF-SMB) concept is extended to the general scenario which integrates a simultaneous fractionation of both outlet streams. A model-based optimization approach, previously adopted to investigate single fractionation, is extended to consider this flexible fractionation policy. Quantitative optimization studies based on a specific separation problem reveal that the double fractionation is the most efficient operating scheme in terms of maximum feed throughput, while the two existing single fractionation modes discussed in our previous study are also significantly superior to the conventional SMB operation. The advantages of the double fractionation extension are further demonstrated in terms of several more detailed performance criteria. In order to evaluate the applicability of the fractionation and feedback modification, the effect of product purity, adsorption selectivity, column efficiency and column number on the relative potential of FF-SMB over SMB is examined.     

Experimental investigation on reversal of secondary Bjerknes force between two bubbles in ultrasonic standing wave

The direction of the secondary Bjerknes force between a free bubble and an attached bubble was experimentally investigated. The behavior of the two bubbles in an ultrasonic standing wave of 27 kHz was observed using an imaging system with a high-speed video camera. It was demonstrated experimentally that the direction of the force reversed at a specific separation distance between the two bubbles, which was defined as the threshold distance. The threshold distance changed with the radius of the attached bubble. In addition, a theoretical calculation was performed using a previously derived model that coupled the vibrations of two free bubbles [Ida, Phys. Lett. A 297, 210-217 (2002)]. The experiment data for the threshold distance qualitatively agreed with the theoretical predictions, except when the separation distance was very small. Then, it was discovered that the free bubble became trapped near the attached bubble when the separation distance between the two bubbles was very small. This indicated that a stable equilibrium point for the separation distance exists that cannot be predicted by the theoretical model.     

Charmonium spectra at finite temperature from QCD sum rules with the maximum entropy method

Charmonia spectral functions at finite temperature are studied using QCD sum rules in combination with the maximum entropy method. This approach enables us to directly obtain the spectral function from the sum rules, without having to introduce any specific assumption about its functional form. As a result, it is found that while J/ψ and η(c) manifest themselves as significant peaks in the spectral function below the deconfinement temperature T(c), they quickly dissolve into the continuum and almost completely disappear at temperatures between 1.0T(c) and 1.1T(c).     

Evolution of the Kondo effect in a quantum dot probed by shot noise

We measure the current and shot noise in a quantum dot in the Kondo regime to address the nonequilibrium properties of the Kondo effect. By systematically tuning the temperature and gate voltages to define the level positions in the quantum dot, we observe an enhancement of the shot noise as temperature decreases below the Kondo temperature, which indicates that the two-particle scattering process grows as the Kondo state evolves. Below the Kondo temperature, the Fano factor defined at finite temperature is found to exceed the expected value of unity from the noninteracting model, reaching 1.8±0.2.     

基于MPS方法的汽泡凝结数值模拟研究

采用移动粒子半隐式(MPS)方法对静止过冷水中单个汽泡的凝结现象进行了数值模拟,研究了不同初始压力和初始直径时饱和蒸汽汽泡凝结过程,获得了凝结过程中汽泡形状、当量直径和压力的变化规律;汽泡初始压力为0.1～0.5MPa,初始直径为2mm、3mm和5mm;过冷水压力为0.1MPa,温度为70℃。结果表明两相界面不存在压差时,凝结过程中汽泡始终保持球形,汽泡当量直径逐渐减小,压力近似不变;相界面存在压差时,凝结过程中汽泡从球形逐渐变为心形、半月形,汽泡当量直径和压力会出现周期性振荡,且初始压力越大振荡幅度越大。     

Application of ion-exchange cartridge clean-up in food analysis. II. Determination of benzylpenicillin, phenoxymethylpenicillin, oxacillin, cloxacillin, nafcillin and dicloxacillin in meat using liquid chromatography with ultraviolet detection.

A multiresidue analytical method was developed for the simultaneous determination of benzylpenicillin (PCG), phenoxymethylpenicillin (PCV), oxacillin (MPIPC), cloxacillin (MCIPC), nafcillin (NFPC) and dicloxacillin (MDIPC) in meat. The method involves the use of an ion-exchange cartridge for sample clean-up followed by ion-pair high-performance liquid chromatography with ultraviolet detection. The recoveries of PCG, PCV, MPIPC, MCIPC, NFPC and MDIPC from pork muscle spiked at levels of 0.5, 0.1 and 0.05 mg/kg were in the range of 77-90, 73-95 and 80-93% with coefficients of variation of 0.5-1.7, 1.6-4.4 and 3.2-6.6%, respectively. For beef muscle spiked at levels of 0.5, 0.1 and 0.05 mg/kg, the recoveries of these compounds were 83-92, 71-86 and 77-90% with coefficients of variation of 1.7-4.4, 2.6-7.0 and 3.9-6.4%, respectively. The detection limits for each penicillin were 0.02 mg/kg in meat.